FOG03524
EOG8N2Z3R

sce:SSN2

Genes: 32

SGD Description
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation


PomBase Description
mediator complex subunit Med13


AspGD Description
Has domain(s) with predicted RNA polymerase II transcription cofactor activity, role in regulation of transcription from RNA polymerase II promoter and mediator complex localization


References

Hengartner CJ, et al. (1995 Apr 15). Association of an activator with an RNA polymerase II holoenzyme.

Yuryev A, et al. (1996 Jun). Suppression analysis reveals a functional difference between the serines in positions two and five in the consensus sequence of the C-terminal domain of yeast RNA polymerase II.

Borggrefe T, et al. (2002 Nov 15). A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast.

Samuelsen CO, et al. (2003 May 27). TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.

Guglielmi B, et al. (2004). A high resolution protein interaction map of the yeast Mediator complex.

Chang YW, et al. (2004 Jul 2). The Ras/PKA signaling pathway directly targets the Srb9 protein, a component of the general RNA polymerase II transcription apparatus.

van de Peppel J, et al. (2005 Aug 19). Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets.

Larschan E, et al. (2005 Jan). The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription.

Nair D, et al. (2005 Oct 7). Mediator and TFIIH govern carboxyl-terminal domain-dependent transcription in yeast extracts.

Andrau JC, et al. (2006 Apr 21). Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA.

Linder T, et al. (2008 May). Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Khorosjutina O, et al. (2010 Sep 24). A chromatin-remodeling protein is a component of fission yeast mediator.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Banyai G, et al. (2014 Nov). Mediator can regulate mitotic entry and direct periodic transcription in fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Banyai G, et al. (2017 Jul 1). Cyclin C influences the timing of mitosis in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 11 genes with posterior transmembrane prediction > 50%