FOG03496
EOG8RR51M
sce:ATG18
Genes: 34
EOG8RR51M
sce:ATG18
Genes: 34
SGD Description
Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
PomBase Description
WD repeat protein involved in autophagy Atg18a
AspGD Description
Phosphoinositide binding protein; predicted role in autophagy
References
Guan J, et al. (2001 Dec). Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris.
Rabitsch KP, et al. (2001 Jul 10). A screen for genes required for meiosis and spore formation based on whole-genome expression.
Barth H, et al. (2001 Nov 9). Autophagy and the cytoplasm to vacuole targeting pathway both require Aut10p.
Georgakopoulos T, et al. (2001 Sep 15). Functional analysis of the Saccharomyces cerevisiae YFR021w/YGR223c/YPL100w ORF family suggests relations to mitochondrial/peroxisomal functions and amino acid signalling pathways.
Klionsky DJ, et al. (2003 Oct). A unified nomenclature for yeast autophagy-related genes.
Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.
Strømhaug PE, et al. (2004 Aug). Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy.
Reggiori F, et al. (2004 Jan). The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure.
Dove SK, et al. (2004 May 5). Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors.
Meiling-Wesse K, et al. (2004 Sep 3). Atg21 is required for effective recruitment of Atg8 to the preautophagosomal structure during the Cvt pathway.
Krick R, et al. (2006 Aug 21). The relevance of the phosphatidylinositolphosphat-binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy.
Efe JA, et al. (2007 Nov). Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate.
Ma J, et al. (2008 Aug). Localization of autophagy-related proteins in yeast using a versatile plasmid-based resource of fluorescent protein fusions.
Obara K, et al. (2008 Aug 29). The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function.
He C, et al. (2008 Dec). Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy.
Jin N, et al. (2008 Dec 17). VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.
Krick R, et al. (2008 Oct). Dissecting the localization and function of Atg18, Atg21 and Ygr223c.
Mukaiyama H, et al. (2009 Dec). Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation.
Nair U, et al. (2010 Apr 9). Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy.
Nair U, et al. (2011 Dec). GFP-Atg8 protease protection as a tool to monitor autophagosome biogenesis.
Han BK, et al. (2011 May 1). Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1.
Baskaran S, et al. (2012 Aug 10). Two-site recognition of phosphatidylinositol 3-phosphate by PROPPINs in autophagy.
Krick R, et al. (2012 Jul 24). Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs, a β-propeller protein family.
Kobayashi T, et al. (2012 Jul 30). Autophagosome formation can be achieved in the absence of Atg18 by expressing engineered PAS-targeted Atg2.
Taylor R Jr, et al. (2012 Sep). KCS1 deletion in Saccharomyces cerevisiae leads to a defect in translocation of autophagic proteins and reduces autophagosome formation.
Zieger M, et al. (2012 Sep). Yeast vacuoles fragment in an asymmetrical two-phase process with distinct protein requirements.
Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.
Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Papinski D, et al. (2014 Jul). Atg1 kinase organizes autophagosome formation by phosphorylating Atg9.
Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
Zhang X, et al. (2015 Oct 9). Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.
Burr R, et al. (2016 Jun 3). Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.
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| Phobius transmembrane predictions
19 genes with posterior transmembrane prediction > 50% |
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FOG03497
EOG87WM64
EOG8RR51M
sce:HSV2
Genes: 33
EOG87WM64
EOG8RR51M
sce:HSV2
Genes: 33
SGD Description
Phosphatidylinositol 3,5-bisphosphate-binding protein; plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization
PomBase Description
WD repeat protein involved in autophagy Atg18c
AspGD Description
Ortholog(s) have phosphatidylinositol-3,5-bisphosphate binding activity and role in macroautophagy, piecemeal microautophagy of nucleus
References
Georgakopoulos T, et al. (2001 Sep 15). Functional analysis of the Saccharomyces cerevisiae YFR021w/YGR223c/YPL100w ORF family suggests relations to mitochondrial/peroxisomal functions and amino acid signalling pathways.
Dove SK, et al. (2004 May 5). Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors.
Krick R, et al. (2008 Oct). Dissecting the localization and function of Atg18, Atg21 and Ygr223c.
Kung LA, et al. (2009). Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes.
Mukaiyama H, et al. (2009 Dec). Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation.
Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.
Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
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FOG03498
EOG8RR51M
sce:ATG21
Genes: 16
EOG8RR51M
sce:ATG21
Genes: 16
SGD Description
Phosphoinositide binding protein; required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
References
Georgakopoulos T, et al. (2001 Sep 15). Functional analysis of the Saccharomyces cerevisiae YFR021w/YGR223c/YPL100w ORF family suggests relations to mitochondrial/peroxisomal functions and amino acid signalling pathways.
Barth H, et al. (2002 Feb 13). Mai1p is essential for maturation of proaminopeptidase I but not for autophagy.
Klionsky DJ, et al. (2003 Oct). A unified nomenclature for yeast autophagy-related genes.
Strømhaug PE, et al. (2004 Aug). Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy.
Dove SK, et al. (2004 May 5). Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors.
Meiling-Wesse K, et al. (2004 Sep 3). Atg21 is required for effective recruitment of Atg8 to the preautophagosomal structure during the Cvt pathway.
Krick R, et al. (2006 Aug 21). The relevance of the phosphatidylinositolphosphat-binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy.
Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
Krick R, et al. (2008 Oct). Dissecting the localization and function of Atg18, Atg21 and Ygr223c.
Kanki T, et al. (2009 Nov). A genomic screen for yeast mutants defective in selective mitochondria autophagy.
Nair U, et al. (2010 Apr 9). Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy.
Nair U, et al. (2011 Dec). GFP-Atg8 protease protection as a tool to monitor autophagosome biogenesis.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
3 genes with posterior transmembrane prediction > 50% |
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FOG03499
EOG8RR51M
sce:absent
Genes: 5
EOG8RR51M
sce:absent
Genes: 5
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03500
EOG8RR51M
sce:absent
Genes: 1
EOG8RR51M
sce:absent
Genes: 1
PomBase Description
WD repeat protein involved in autophagy Atg18b
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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