FOG03411
EOG866T4M

sce:URE2

Genes: 36

SGD Description
Nitrogen catabolite repression transcriptional regulator; inhibits GLN3 transcription in good nitrogen source; role in sequestering Gln3p and Gat1p to the cytoplasm; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion


PomBase Description
glutathione S-transferase Gst1|glutathione S-transferase Gst2


AspGD Description
Ortholog(s) have glutathione peroxidase activity, glutathione transferase activity and intracellular localization|Ortholog(s) have glutathione peroxidase activity, glutathione transferase activity and cytosol, nucleus localization|Ortholog(s) have glutathione peroxidase activity, glutathione transferase activity, phosphoprotein binding, transcription corepressor activity


References

Coschigano PW, et al. (1991 Feb). The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases.

Wickner RB, et al. (1994 Apr 22). [URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae.

Masison DC, et al. (1995 Oct 6). Prion-inducing domain of yeast Ure2p and protease resistance of Ure2p in prion-containing cells.

Blinder D, et al. (1996 Aug). Interaction of the GATA factor Gln3p with the nitrogen regulator Ure2p in Saccharomyces cerevisiae.

Beck T, et al. (1999 Dec 9). The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors.

Moriyama H, et al. (2000 Dec). [URE3] prion propagation in Saccharomyces cerevisiae: requirement for chaperone Hsp104 and curing by overexpressed chaperone Ydj1p.

Cunningham TS, et al. (2000 May 12). Nitrogen catabolite repression of DAL80 expression depends on the relative levels of Gat1p and Ure2p production in Saccharomyces cerevisiae.

Umland TC, et al. (2001 Feb 13). The crystal structure of the nitrogen regulation fragment of the yeast prion protein Ure2p.

Bousset L, et al. (2001 Jan 10). Structure of the globular region of the prion protein Ure2 from the yeast Saccharomyces cerevisiae.

Bousset L, et al. (2001 Nov 13). Crystal structures of the yeast prion Ure2p functional region in complex with glutathione and related compounds.

Edskes HK, et al. (2002 Dec 10). Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein.

Bai M, et al. (2004 Nov 26). The yeast prion protein Ure2 shows glutathione peroxidase activity in both native and fibrillar forms.

Chan JC, et al. (2005 Aug 9). Parallel beta-sheets and polar zippers in amyloid fibrils formed by residues 10-39 of the yeast prion protein Ure2p.

Baxa U, et al. (2007 Nov 13). Characterization of beta-sheet structure in Ure2p1-89 yeast prion fibrils by solid-state nuclear magnetic resonance.

Zhang ZR, et al. (2009 May 22). Novel glutaredoxin activity of the yeast prion protein Ure2 reveals a native-like dimer within fibrils.

Breitkreutz A, et al. (2010 May 21). A global protein kinase and phosphatase interaction network in yeast.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03412
EOG866T4M

sce:absent

Genes: 34

AspGD Description
Ortholog(s) have glutathione peroxidase activity, glutathione transferase activity


References

Fraser JA, et al. (2002 Jun). A gene from Aspergillus nidulans with similarity to URE2 of Saccharomyces cerevisiae encodes a glutathione S-transferase which contributes to heavy metal and xenobiotic resistance.

Burns C, et al. (2005 Apr). Identification, cloning, and functional expression of three glutathione transferase genes from Aspergillus fumigatus.

Pócsi I, et al. (2005 Dec 20). Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures--linking genome-wide transcriptional changes to cellular physiology.

Sato I, et al. (2009 Mar 20). The glutathione system of Aspergillus nidulans involves a fungus-specific glutathione S-transferase.

Martins I, et al. (2013 Dec 6). Proteomic alterations induced by ionic liquids in Aspergillus nidulans and Neurospora crassa.

Montibus M, et al. (2015). Coupling of transcriptional response to oxidative stress and secondary metabolism regulation in filamentous fungi.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03413
EOG866T4M

sce:absent

Genes: 2

AspGD Description
Ortholog of Aspergillus tubingensis : Asptu1_0113414, Aspergillus kawachii : Aspka1_0177730, Aspergillus acidus : Aspfo1_0205181 and Aspergillus niger ATCC 1015 : 177976-mRNA|Ortholog of Aspergillus tubingensis : Asptu1_0052964, Aspergillus glaucus : Aspgl1_0181752, Aspergillus kawachii : Aspka1_0173366 and Aspergillus acidus : Aspfo1_0130243

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03414
EOG866T4M

sce:absent

Genes: 2

AspGD Description
Ortholog of A. fumigatus Af293 : Afu6g03390, Aspergillus niger ATCC 1015 : 126931-mRNA, Aspergillus zonatus : Aspzo1_0020462, Aspzo1_0132229 and Aspergillus carbonarius ITEM 5010 : Acar5010_127540

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03415
EOG866T4M

sce:absent

Genes: 2

AspGD Description
Ortholog(s) have glutathione peroxidase activity, glutathione transferase activity and intracellular localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03416
EOG866T4M

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%