FOG03405
EOG88GTJQ

sce:RPT3

Genes: 33

SGD Description
ATPase of the 19S regulatory particle of the 26S proteasome; one of ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B


PomBase Description
19S proteasome regulatory subunit Rpt3 (predicted)


AspGD Description
Ortholog(s) have role in positive regulation of RNA polymerase II transcriptional preinitiation complex assembly, proteasome regulatory particle assembly, ubiquitin-dependent protein catabolic process


References

Campbell CL, et al. (1994 Aug). Mitochondrial morphological and functional defects in yeast caused by yme1 are suppressed by mutation of a 26S protease subunit homologue.

Schnall R, et al. (1994 Sep). Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex.

Kimura Y, et al. (2003 Jan 15). N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03406
EOG88GTJQ

sce:RPT1

Genes: 33

SGD Description
ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance


PomBase Description
19S proteasome regulatory subunit Rpt1 (predicted)


AspGD Description
Ortholog(s) have role in positive regulation of RNA polymerase II transcriptional preinitiation complex assembly, positive regulation of protein catabolic process and proteasome regulatory particle assembly, more


References

Ghislain M, et al. (1993 Nov 25). S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase.

Schnall R, et al. (1994 Sep). Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex.

Xie Y, et al. (2000 Mar 14). Physical association of ubiquitin ligases and the 26S proteasome.

Jäger S, et al. (2001 Aug 15). Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4.

Kimura Y, et al. (2003 Jan 15). N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03407
EOG88GTJQ

sce:RPT6

Genes: 33

SGD Description
ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress


PomBase Description
19S proteasome regulatory subunit Rpt6 (predicted)


AspGD Description
Ortholog(s) have protein domain specific binding activity


References

Swaffield JC, et al. (1992 Jun 25). Alterations in a yeast protein resembling HIV Tat-binding protein relieve requirement for an acidic activation domain in GAL4.

Goyer C, et al. (1992 Oct). Isolation of a yeast gene encoding a protein homologous to the human Tat-binding protein TBP-1.

Rubin DM, et al. (1996 Feb 15). Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome.

Feuermann M, et al. (1997 Jul). The characterization of two new clusters of duplicated genes suggests a 'Lego' organization of the yeast Saccharomyces cerevisiae chromosomes.

Xie Y, et al. (2000 Mar 14). Physical association of ubiquitin ligases and the 26S proteasome.

Kimura Y, et al. (2003 Jan 15). N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome.

Guerrero C, et al. (2006 Feb). An integrated mass spectrometry-based proteomic approach: quantitative analysis of tandem affinity-purified in vivo cross-linked protein complexes (QTAX) to decipher the 26 S proteasome-interacting network.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Hanssum A, et al. (2014 Aug 21). An inducible chaperone adapts proteasome assembly to stress.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03408
EOG88GTJQ

sce:RPT2

Genes: 33

SGD Description
ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle; N-myristoylation of Rpt2p at Gly2 is involved in regulating the proper intracellular distribution of proteasome activity by controlling the nuclear localization of the 26S proteasome


PomBase Description
19S proteasome regulatory subunit Rpt2


AspGD Description
Protein similar to 26S ATP/ubiquitin-dependent proteinase chain S4


References

Schnall R, et al. (1994 Sep). Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex.

Lucero HA, et al. (1995 Apr 21). Cloning and expression of a yeast gene encoding a protein with ATPase activity and high identity to the subunit 4 of the human 26 S protease.

Wilkinson CR, et al. (1997 Oct 10). Mts4, a non-ATPase subunit of the 26 S protease in fission yeast is essential for mitosis and interacts directly with the ATPase subunit Mts2.

Tatebe H, et al. (2000 Nov 2). Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.

Decottignies A, et al. (2001 Jul). In vivo localisation of fission yeast cyclin-dependent kinase cdc2p and cyclin B cdc13p during mitosis and meiosis.

Dunand-Sauthier I, et al. (2002 May). Sum1, a component of the fission yeast eIF3 translation initiation complex, is rapidly relocalized during environmental stress and interacts with components of the 26S proteasome.

Yen HC, et al. (2003 Aug 15). Rpn5 is a conserved proteasome subunit and required for proper proteasome localization and assembly.

Kimura Y, et al. (2003 Jan 15). N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome.

Yen HC, et al. (2003 Jan 24). Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome.

Seeger M, et al. (2003 May 9). Interaction of the anaphase-promoting complex/cyclosome and proteasome protein complexes with multiubiquitin chain-binding proteins.

Stone M, et al. (2004 Nov 26). Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast.

Takeda K, et al. (2005 Aug 12). Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8.

Jossé L, et al. (2006 Jan 1). Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis.

Mannen T, et al. (2008 Jan 25). Dss1 associating with the proteasome functions in selective nuclear mRNA export in yeast.

Bohn S, et al. (2010 Dec 7). Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution.

Takeda K, et al. (2010 Feb 23). Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

Selvanathan SP, et al. (2010 May 7). Schizosaccharomyces pombe Dss1p is a DNA damage checkpoint protein that recruits Rad24p, Cdc25p, and Rae1p to DNA double-strand breaks.

Anderson HE, et al. (2010 Oct 18). Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4.

Cabrera R, et al. (2010 Sep 15). Proteasome nuclear import mediated by Arc3 can influence efficient DNA damage repair and mitosis in Schizosaccharomyces pombe.

Kouranti I, et al. (2010 Sep 7). A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Matsuo Y, et al. (2011 Apr 15). Nuclear protein quality is regulated by the ubiquitin-proteasome system through the activity of Ubc4 and San1 in fission yeast.

Duncan CD, et al. (2011 Dec). Widespread cotranslational formation of protein complexes.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Penney M, et al. (2012). Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the Pap1 transcription factor.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Lasker K, et al. (2012 Jan 31). Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Fujiwara H, et al. (2013 Jan). Essential role of Ubr11, but not Ubr1, as an N-end rule ubiquitin ligase in Schizosaccharomyces pombe.

Kitagawa T, et al. (2014 Apr 7). The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Kriegenburg F, et al. (2014 Jan). A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability.

Otsubo Y, et al. (2014 Jun 15). S. pombe TORC1 activates the ubiquitin-proteasomal degradation of the meiotic regulator Mei2 in cooperation with Pat1 kinase.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Kampmeyer C, et al. (2017 Sep 15). The exocyst subunit Sec3 is regulated by a protein quality control pathway.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03409
EOG88GTJQ

sce:RPT5

Genes: 33

SGD Description
ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1


PomBase Description
19S proteasome regulatory subunit Rpt5 (predicted)


AspGD Description
Ortholog(s) have role in positive regulation of RNA polymerase II transcriptional preinitiation complex assembly, proteasome regulatory particle assembly, ubiquitin-dependent protein catabolic process


References

Schnall R, et al. (1994 Sep). Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex.

Kimura Y, et al. (2003 Jan 15). N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome.

Jossé L, et al. (2006 Jan 1). Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis.

Bohn S, et al. (2010 Dec 7). Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution.

Takeda K, et al. (2010 Feb 23). Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

Anderson HE, et al. (2010 Oct 18). Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4.

Kouranti I, et al. (2010 Sep 7). A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Lasker K, et al. (2012 Jan 31). Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Chen JS, et al. (2013 May). Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Zilio N, et al. (2014 Sep 15). A novel histone deacetylase complex in the control of transcription and genome stability.

Mathiassen SG, et al. (2015 Aug 21). A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lucena R, et al. (2015 May 11). Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03410
EOG88GTJQ

sce:RPT4

Genes: 33

SGD Description
ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization


PomBase Description
19S proteasome regulatory subunit Rpt4 (predicted)


AspGD Description
Ortholog(s) have protein domain specific binding activity


References

Russell SJ, et al. (1996 Dec 20). Isolation and characterization of SUG2. A novel ATPase family component of the yeast 26 S proteasome.

McDonald HB, et al. (1997 May 5). A proteasome cap subunit required for spindle pole body duplication in yeast.

Kimura Y, et al. (2003 Jan 15). N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome.

Bohn S, et al. (2010 Dec 7). Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution.

Takeda K, et al. (2010 Feb 23). Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

Anderson HE, et al. (2010 Oct 18). Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4.

Kouranti I, et al. (2010 Sep 7). A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Gatti L, et al. (2011 Jan 19). Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.

Lasker K, et al. (2012 Jan 31). Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Zilio N, et al. (2014 Sep 15). A novel histone deacetylase complex in the control of transcription and genome stability.

Mathiassen SG, et al. (2015 Aug 21). A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lucena R, et al. (2015 May 11). Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%