FOG03356
EOG8JSXQ1
sce:GZF3;DAL80
Genes: 34
EOG8JSXQ1
sce:GZF3;DAL80
Genes: 34
SGD Description
GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication|Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
AspGD Description
Ortholog(s) have sequence-specific DNA binding activity and role in sporocarp development involved in sexual reproduction
References
Tollervey DW, et al. (1982 Oct). Domain-wide, locus-specific suppression of nitrogen metabolite repressed mutations in Aspergillus nidulans.
Arst HN Jr, et al. (1984 Sep). Regulation of gene expression in Aspergillus nidulans.
Wiame JM, et al. (1985). Nitrogen catabolite repression in yeasts and filamentous fungi.
Arst HN Jr, et al. (1989 Jan). A translocation associated, loss-of-function mutation in the nitrogen metabolite repression regulatory gene of Aspergillus nidulans can revert intracistronically.
Arst HN Jr, et al. (1990 Aug). A translocation activating the cryptic nitrogen regulation gene areB inactivates a previously unidentified gene involved in glycerol utilisation in Aspergillus nidulans.
Cunningham TS, et al. (1991 Dec). Expression of the DAL80 gene, whose product is homologous to the GATA factors and is a negative regulator of multiple nitrogen catabolic genes in Saccharomyces cerevisiae, is sensitive to nitrogen catabolite repression.
Coornaert D, et al. (1992 Apr). The UGA43 negative regulatory gene of Saccharomyces cerevisiae contains both a GATA-1 type zinc finger and a putative leucine zipper.
Cunningham TS, et al. (1992 May). Expression of the DAL80 gene, whose product is homologous to the GATA factors and is a negative regulator of multiple nitrogen catabolic genes in Saccharomyces cerevisiae, is sensitive to nitrogen catabolite repression.
Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.
Conlon H, et al. (2001 Apr). The Aspergillus nidulans GATA transcription factor gene areB encodes at least three proteins and features three classes of mutation.
Dzikowska A, et al. (2003 Mar). Specific induction and carbon/nitrogen repression of arginine catabolism gene of Aspergillus nidulans--functional in vivo analysis of the otaA promoter.
Wang Y, et al. (2006 Apr 1). Cap1p is involved in multiple pathways of oxidative stress response in Candida albicans.
Caddick MX, et al. (2006 Oct). Opposing signals differentially regulate transcript stability in Aspergillus nidulans.
Homann OR, et al. (2009 Dec). A phenotypic profile of the Candida albicans regulatory network.
Wong KH, et al. (2009 Dec). Deletion and overexpression of the Aspergillus nidulans GATA factor AreB reveals unexpected pleiotropy.
Hagiwara D, et al. (2009 Nov). Transcriptional profiling for Aspergillusnidulans HogA MAPK signaling pathway in response to fludioxonil and osmotic stress.
Nobile CJ, et al. (2012 Jan 20). A recently evolved transcriptional network controls biofilm development in Candida albicans.
Macios M, et al. (2012 Mar). The GATA factors AREA and AREB together with the co-repressor NMRA, negatively regulate arginine catabolism in Aspergillus nidulans in response to nitrogen and carbon source.
Tudzynski B, et al. (2014). Nitrogen regulation of fungal secondary metabolism in fungi.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03357
EOG8JSXQ1
sce:GAT1
Genes: 33
EOG8JSXQ1
sce:GAT1
Genes: 33
SGD Description
Transcriptional activator of nitrogen catabolite repression genes; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p; different translational starts produce two major and two minor isoforms that are differentially regulated and localized
PomBase Description
transcription factor Gaf1
AspGD Description
Sequence-specific DNA binding transcription regulator; wide domain regulatory gene that controls nitrogen utilization; Northern blot indicates multiple transcripts
References
Hynes MJ, et al. (1970). The genetic analysis of regulation of amidase synthesis in Aspergillus nidulans. I. Mutants able to utilize acrylamide.
Hynes MJ, et al. (1972 Sep). Mutants with altered glucose repression of amidase enzymes in Aspergillus nidulans.
Cohen BL, et al. (1973 Dec). Regulation of intracellular and extracellular neutral and alkaline proteases in Aspergillus nidulans.
Pateman JA, et al. (1973 Jun). Ammonium regulation in Aspergillus nidulans.
Arst HN Jr, et al. (1973 Nov 2). Nitrogen metabolite repression in Aspergillus nidulans.
Hynes MJ, et al. (1973 Sep 18). Alterations in the control of glutamate uptake in mutants of Aspergillus nidulans.
Hynes MJ, et al. (1973 Sep 5). Pleiotropic mutants affecting the control of nitrogen metabolism in Aspergillus nidulans.
Hynes MJ, et al. (1974 Dec). Effects of ammonium, L-glutamate, and L-glutamine on nitrogen catabolism in Aspergillus nidulans.
Hynes MJ, et al. (1974 Mar). The effects of carbon source on glutamate dehydrogenase activities in Aspergillus nidulans.
Bailey C, et al. (1975 Feb 21). Carbon catabolite repression in Aspergillos nidulans.
Hynes MJ, et al. (1975 Jun). Studies on the role of the areA gene in the regulation of nitrogen catabolism in Aspergillus nidulans.
Arst HN Jr, et al. (1975 Mar 6). Initiator constitutive mutation with an 'up-promoter' effect in Aspergillus nidulans.
Hynes MJ, et al. (1975 Nov). Amide utilization in Aspergillus nidulans: evidence for a third amidase enzyme.
Polya GM, et al. (1975 Nov). Enzymology and genetic regulation of a cyclic nucleotide-binding phosphodiesterase-phosphomonoesterase from Aspergillus nidulans.
Kinghorn JR, et al. (1975 Sep 29). Studies of partially repressed mutants at the tamA and areA loci in Aspergillus nidulans.
Bartnik E, et al. (1976). Effect of the areA gene on regulation of arginine catabolism in Aspergillus nidulans.
Arst HN Jr, et al. (1976 Jul 15). Integrator gene in Aspergillus nidulans.
Cove DJ, et al. (1976 Jul 23). Chlorate toxicity in Aspergillus nidulans. Studies of mutants altered in nitrate assimilation.
Rand KN, et al. (1977 Sep 21). A mutation in Aspergillus nidulans which affects the regulation of nitrite reductase and is tightly linked to its structural gene.
Garrett RH, et al. (1978). Nitrate assimilation in fungi.
Hynes MJ, et al. (1978 Apr 25). Multiple independent control mechanisms affecting the acetamidase of Aspergillus nidulans.
Cove DJ, et al. (1979 Aug). Genetic studies of nitrate assimilation in Aspergillus nidulans.
Bailey CR, et al. (1979 Jan 16). Cis-dominant regulatory mutations affecting the expression of GABA permease in Aspergillus nidulans.
Bailey CR, et al. (1980 Oct). A third gene affecting GABA transaminase levels in Aspergillus nidulans.
Arst HN Jr, et al. (1982). A near terminal pericentric inversion leads to nitrogen metabolite derepression in Aspergillus nidulans.
Brownlee AG, et al. (1983 Sep). Nitrate uptake in Aspergillus nidulans and involvement of the third gene of the nitrate assimilation gene cluster.
Shaffer PM, et al. (1984). Regulation of pyrimidine salvage in Aspergillus nidulans: a role for the major regulatory gene are A mediating nitrogen metabolite repression.
Arst HN Jr, et al. (1984 Sep). Regulation of gene expression in Aspergillus nidulans.
Wiame JM, et al. (1985). Nitrogen catabolite repression in yeasts and filamentous fungi.
Arst HN Jr, et al. (1986 Jul). Exploiting classical genetics to clone a eukaryotic regulatory gene.
Caddick MX, et al. (1986 May). Cloning of the regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans.
Fincham J, et al. (1986 Oct 30-Nov 5). Genetics of filamentous fungi.
Hynes MJ, et al. (1986 Sep). The amdS gene of Aspergillus nidulans: control by multiple regulatory signals.
Kelly JM, et al. (1987). Multiple copies of the amdS gene of Aspergillus nidulans cause titration of trans-acting regulatory proteins.
Davis MA, et al. (1987 Jun). Complementation of areA- regulatory gene mutations of Aspergillus nidulans by the heterologous regulatory gene nit-2 of Neurospora crassa.
Hynes MJ, et al. (1988 Jun). Identification of the sites of action for regulatory genes controlling the amdS gene of Aspergillus nidulans.
Shaffer PM, et al. (1988 May). An asparaginase of Aspergillus nidulans is subject to oxygen repression in addition to nitrogen metabolite repression.
Arst HN Jr, et al. (1989 Jan). A translocation associated, loss-of-function mutation in the nitrogen metabolite repression regulatory gene of Aspergillus nidulans can revert intracistronically.
Davis MA, et al. (1989 Jan). Regulatory genes in Aspergillus nidulans.
Richardson IB, et al. (1989 May). Cloning and molecular characterisation of the amdR controlled gatA gene of Aspergillus nidulans.
Arst HN Jr, et al. (1989 Sep). Aspergillus and mouse share a new class of 'zinc finger' protein.
Kudla B, et al. (1990 May). The regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans. Mutations affecting specificity of gene activation alter a loop residue of a putative zinc finger.
Scazzocchio C, et al. (1990 Oct). Of moulds and men, or two fingers are not better than one.
Caddick MX, et al. (1990 Oct 30). Nitrogen regulation in Aspergillus: are two fingers better than one?
Minehart PL, et al. (1991 Dec). Sequence and expression of GLN3, a positive nitrogen regulatory gene of Saccharomyces cerevisiae encoding a protein with a putative zinc finger DNA-binding domain.
Unkles SE, et al. (1991 Jan 1). crnA encodes a nitrate transporter in Aspergillus nidulans.
Lloyd AT, et al. (1991 Nov). Codon usage in Aspergillus nidulans.
Scazzocchio C, et al. (1992). Control of gene expression in the catabolic pathways of Aspergillus nidulans: a personal and biased account.
Hawker KL, et al. (1992 Feb). Nitrate reductase and nitrite reductase transcript levels in various mutants of Aspergillus nidulans: confirmation of autogenous regulation.
Punt PJ, et al. (1992 Oct 12). An upstream activating sequence from the Aspergillus nidulans gpdA gene.
Davis MA, et al. (1993). Fungal catabolic gene regulation: molecular genetic analysis of the amdS gene of Aspergillus nidulans.
Marzluf GA, et al. (1993). Regulation of sulfur and nitrogen metabolism in filamentous fungi.
Stankovich M, et al. (1993 Jan). C-terminal truncation of the transcriptional activator encoded by areA in Aspergillus nidulans results in both loss-of-function and gain-of-function phenotypes.
Gorfinkiel L, et al. (1993 Nov 5). Sequence and regulation of the uapA gene encoding a uric acid-xanthine permease in the fungus Aspergillus nidulans.
Oestreicher N, et al. (1993 Nov 5). Sequence, regulation, and mutational analysis of the gene encoding urate oxidase in Aspergillus nidulans.
Espeso EA, et al. (1993 Oct). pH regulation is a major determinant in expression of a fungal penicillin biosynthetic gene.
Caddick MX, et al. (1994). Nitrogen regulation in fungi.
Hynes MJ, et al. (1994). Regulation of acetamide utilization.
Hynes MJ, et al. (1994). Regulatory circuits of the amdS gene of Aspergillus nidulans.
Kinghorn JR, et al. (1994). Inorganic nitrogen assimilation: molecular aspects.
Scazzocchio C, et al. (1994). The proline utilisation pathway, history and beyond.
Scazzocchio C, et al. (1994). The purine degradation pathway, genetics, biochemistry and regulation.
Peters DG, et al. (1994 Dec 11). Direct analysis of native and chimeric GATA specific DNA binding proteins from Aspergillus nidulans.
Hawkins AR, et al. (1994 Sep 2). Evolution of transcription-regulating proteins by enzyme recruitment: molecular models for nitrogen metabolite repression and ethanol utilisation in eukaryotes.
Diallinas G, et al. (1995 Apr 14). Genetic and molecular characterization of a gene encoding a wide specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes.
Glatigny A, et al. (1995 Feb 24). Cloning and molecular characterization of hxA, the gene coding for the xanthine dehydrogenase (purine hydroxylase I) of Aspergillus nidulans.
Sophianopoulou V, et al. (1995 Jan). Amino acid transporters of lower eukaryotes: regulation, structure and topogenesis.
Punt PJ, et al. (1995 Oct). The intergenic region between the divergently transcribed niiA and niaD genes of Aspergillus nidulans contains multiple NirA binding sites which act bidirectionally.
Langdon T, et al. (1995 Sep). Mutational analysis reveals dispensability of the N-terminal region of the Aspergillus transcription factor mediating nitrogen metabolite repression.
Katz ME, et al. (1996 Apr 10). Mutations affecting extracellular protease production in the filamentous fungus Aspergillus nidulans.
Platt A, et al. (1996 Jan 15). Mutational analysis of the C-terminal region of AREA, the transcription factor mediating nitrogen metabolite repression in Aspergillus nidulans.
Davis MA, et al. (1996 Jun). The tamA gene of Aspergillus nidulans contains a putative zinc cluster motif which is not required for gene function.
Platt A, et al. (1996 Jun 3). Nitrogen metabolite signalling involves the C-terminus and the GATA domain of the Aspergillus transcription factor AREA and the 3' untranslated region of its mRNA.
Arst HN Jr, et al. (1996 Mar). Translational initiation competence, 'leaky scanning' and translational reinitiation in areA mRNA of Aspergillus nidulans.
Coffman JA, et al. (1996 Mar). Gat1p, a GATA family protein whose production is sensitive to nitrogen catabolite repression, participates in transcriptional activation of nitrogen-catabolic genes in Saccharomyces cerevisiae.
Shroff RA, et al. (1996 Sep). Analysis of mutations in the creA gene involved in carbon catabolite repression in Aspergillus nidulans.
Shroff RA, et al. (1997 Aug). Null alleles of creA, the regulator of carbon catabolite repression in Aspergillus nidulans.
Caddick MX, et al. (1997 Feb). Genetic and molecular characterization of murine GATA-1 in Aspergillus defines a critical role for the N-terminal finger.
Ravagnani A, et al. (1997 Jul 1). Subtle hydrophobic interactions between the seventh residue of the zinc finger loop and the first base of an HGATAR sequence determine promoter-specific recognition by the Aspergillus nidulans GATA factor AreA.
Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.
Screen S, et al. (1997 Jun). Carbon regulation of the cuticle-degrading enzyme PR1 from Metarhizium anisopliae may involve a trans-acting DNA-binding protein CRR1, a functional equivalent of the Aspergillus nidulans CREA protein.
Gonzalez R, et al. (1997 May 15). The integration of nitrogen and carbon catabolite repression in Aspergillus nidulans requires the GATA factor AreA and an additional positive-acting element, ADA.
Lockington RA, et al. (1997 May 20). Pyruvate decarboxylase and anaerobic survival in Aspergillus nidulans.
Lamb HK, et al. (1997 Nov). Deletion of the N-terminal region of the AREA protein is correlated with a derepressed phenotype with respect to nitrogen metabolite repression.
Andrianopoulos A, et al. (1998 Apr). Characterization of the Aspergillus nidulans nmrA gene involved in nitrogen metabolite repression.
Starich MR, et al. (1998 Apr 3). The solution structure of a fungal AREA protein-DNA complex: an alternative binding mode for the basic carboxyl tail of GATA factors.
Starich MR, et al. (1998 Apr 3). The solution structure of the Leu22-->Val mutant AREA DNA binding domain complexed with a TGATAG core element defines a role for hydrophobic packing in the determination of specificity.
Pereira M, et al. (1998 Jul). The areA(r) mutation of Aspergillus nidulans confers low pH sensitivity in the presence of ammonium as the only nitrogen source.
Caddick MX, et al. (1998 Nov). Deletion of the 389 N-terminal residues of the transcriptional activator AREA does not result in nitrogen metabolite derepression in Aspergillus nidulans.
Screen S, et al. (1998 Oct 9). Isolation of a nitrogen response regulator gene (nrr1) from Metarhizium anisopliae.
Wilson RA, et al. (1998 Sep). Mutational analysis of AREA, a transcriptional activator mediating nitrogen metabolite repression in Aspergillus nidulans and a member of the "streetwise" GATA family of transcription factors.
Amrani L, et al. (1999 Feb). The hxB gene, necessary for the post-translational activation of purine hydroxylases in Aspergillus nidulans, is independently controlled by the purine utilization and the nicotinate utilization transcriptional activating systems.
Tudzynski B, et al. (1999 Feb). Isolation, characterization and disruption of the areA nitrogen regulatory gene of Gibberella fujikuroi.
Snoeijers SS, et al. (1999 Jun). Transcription of the avirulence gene Avr9 of the fungal tomato pathogen Cladosporium fulvum is regulated by a GATA-type transcription factor in Aspergillus nidulans.
Dzikowska A, et al. (1999 Mar). Cloning, characterisation and regulation of the ornithine transaminase (otaA) gene of Aspergillus nidulans.
Muro-Pastor MI, et al. (1999 Mar 15). The GATA factor AreA is essential for chromatin remodelling in a eukaryotic bidirectional promoter.
Hutchings H, et al. (1999 May). The multiply-regulated gabA gene encoding the GABA permease of Aspergillus nidulans: a score of exons.
Small AJ, et al. (1999 Sep). The TamA protein fused to a DNA-binding domain can recruit AreA, the major nitrogen regulatory protein, to activate gene expression in Aspergillus nidulans.
Cubero B, et al. (2000 Jan). Metabolite repression and inducer exclusion in the proline utilization gene cluster of Aspergillus nidulans.
Todd RB, et al. (2000 May). The Aspergillus nidulans creC gene involved in carbon catabolite repression encodes a WD40 repeat protein.
Manfield IW, et al. (2000 Oct 2). The DNA-binding domain of the gene regulatory protein AreA extends beyond the minimal zinc-finger region conserved between GATA proteins.
Morozov IY, et al. (2000 Sep). A defined sequence within the 3' UTR of the areA transcript is sufficient to mediate nitrogen metabolite signalling via accelerated deadenylation.
Conlon H, et al. (2001 Apr). The Aspergillus nidulans GATA transcription factor gene areB encodes at least three proteins and features three classes of mutation.
Weidner G, et al. (2001 Feb). The Aspergillus nidulans homoaconitase gene lysF is negatively regulated by the multimeric CCAAT-binding complex AnCF and positively regulated by GATA sites.
Fraser JA, et al. (2001 Jan). The formamidase gene of Aspergillus nidulans: regulation by nitrogen metabolite repression and transcriptional interference by an overlapping upstream gene.
Lockington RA, et al. (2001 Jun). Carbon catabolite repression in Aspergillus nidulans involves deubiquitination.
Small AJ, et al. (2001 Jun). Functional analysis of TamA, a coactivator of nitrogen-regulated gene expression in Aspergillus nidulans.
Pérez-García A, et al. (2001 Mar). Expression of the Avirulence gene Avr9 of the fungal tomato pathogen Cladosporium fulvum is regulated by the global nitrogen response factor NRF1.
Unkles SE, et al. (2001 Nov 15). Apparent genetic redundancy facilitates ecological plasticity for nitrate transport.
Margelis S, et al. (2001 Oct). Role of glutamine synthetase in nitrogen metabolite repression in Aspergillus nidulans.
Morozov IY, et al. (2001 Oct). Characterization of nitrogen metabolite signalling in Aspergillus via the regulated degradation of areA mRNA.
Lenouvel F, et al. (2001 Sep). Isolation of UV-induced mutations in the areA nitrogen regulatory gene of Aspergillus niger, and construction of a disruption mutant.
Narendja F, et al. (2002 Apr). Nitrate and the GATA factor AreA are necessary for in vivo binding of NirA, the pathway-specific transcriptional activator of Aspergillus nidulans.
Monahan BJ, et al. (2002 Jun). Mutation and functional analysis of the Aspergillus nidulans ammonium permease MeaA and evidence for interaction with itself and MepA.
Fraser JA, et al. (2002 Mar). The genes gmdA, encoding an amidase, and bzuA, encoding a cytochrome P450, are required for benzamide utilization in Aspergillus nidulans.
Lockington RA, et al. (2002 Nov). Regulation by carbon and nitrogen sources of a family of cellulases in Aspergillus nidulans.
Calvo AM, et al. (2002 Sep). Relationship between secondary metabolism and fungal development.
Lamb HK, et al. (2003 Aug 22). The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides.
Tanzer MM, et al. (2003 Dec). Global nutritional profiling for mutant and chemical mode-of-action analysis in filamentous fungi.
Fernández-Martínez J, et al. (2003 Dec 5). Overlap of nuclear localisation signal and specific DNA-binding residues within the zinc finger domain of PacC.
Mihlan M, et al. (2003 Feb). AREA directly mediates nitrogen regulation of gibberellin biosynthesis in Gibberella fujikuroi, but its activity is not affected by NMR.
Dzikowska A, et al. (2003 Mar). Specific induction and carbon/nitrogen repression of arginine catabolism gene of Aspergillus nidulans--functional in vivo analysis of the otaA promoter.
Pellier AL, et al. (2003 May). CLNR1, the AREA/NIT2-like global nitrogen regulator of the plant fungal pathogen Colletotrichum lindemuthianum is required for the infection cycle.
Chant A, et al. (2003 May 30). Structural and functional characterisation of the DNA binding domain of the Aspergillus nidulans gene regulatory protein AreA.
Limjindaporn T, et al. (2003 Nov). Nitrogen metabolism and virulence of Candida albicans require the GATA-type transcriptional activator encoded by GAT1.
Gómez D, et al. (2003 Oct). Multiple GATA sites: protein binding and physiological relevance for the regulation of the proline transporter gene of Aspergillus nidulans.
Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.
Amillis S, et al. (2004 Apr). Transcription of purine transporter genes is activated during the isotropic growth phase of Aspergillus nidulans conidia.
Muro-Pastor MI, et al. (2004 Apr). A paradoxical mutant GATA factor.
Lamb HK, et al. (2004 Dec). Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis.
García I, et al. (2004 Feb). Chromatin rearrangements in the prnD-prnB bidirectional promoter: dependence on transcription factors.
Cecchetto G, et al. (2004 Jan 30). The AzgA purine transporter of Aspergillus nidulans. Characterization of a protein belonging to a new phylogenetic cluster.
Polotnianka R, et al. (2004 Nov). TamA interacts with LeuB, the homologue of Saccharomyces cerevisiae Leu3p, to regulate gdhA expression in Aspergillus nidulans.
Takahashi T, et al. (2004 Oct). Efficient gene disruption in the koji-mold Aspergillus sojae using a novel variation of the positive-negative method.
Chant A, et al. (2005 Feb). Attachment of a histidine tag to the minimal zinc finger protein of the Aspergillus nidulans gene regulatory protein AreA causes a conformational change at the DNA-binding site.
Davis MA, et al. (2005 Jul). Amino acid catabolism by an areA-regulated gene encoding an L-amino acid oxidase with broad substrate specificity in Aspergillus nidulans.
Todd RB, et al. (2005 Oct). Nuclear accumulation of the GATA factor AreA in response to complete nitrogen starvation by regulation of nuclear export.
Tilburn J, et al. (2005 Sep). Mutational analysis of the pH signal transduction component PalC of Aspergillus nidulans supports distant similarity to BRO1 domain family members.
David H, et al. (2006). Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulans.
Monahan BJ, et al. (2006 Feb). Differential expression of Aspergillus nidulans ammonium permease genes is regulated by GATA transcription factor AreA.
Berger H, et al. (2006 Jan). The GATA factor AreA regulates localization and in vivo binding site occupancy of the nitrate activator NirA.
Yamada T, et al. (2006 May). Isolation, characterization, and disruption of dnr1, the areA/nit-2-like nitrogen regulatory gene of the zoophilic dermatophyte, Microsporum canis.
Morozov IY, et al. (2006 Nov). Nonsense-mediated mRNA decay mutation in Aspergillus nidulans.
Caddick MX, et al. (2006 Oct). Opposing signals differentially regulate transcript stability in Aspergillus nidulans.
Peñas MM, et al. (2007 Jun). Further characterization of the signaling proteolysis step in the Aspergillus nidulans pH signal transduction pathway.
Cultrone A, et al. (2007 Mar). The tightly regulated promoter of the xanA gene of Aspergillus nidulans is included in a helitron.
Dabas N, et al. (2007 May). Control of ammonium permease expression and filamentous growth by the GATA transcription factors GLN3 and GAT1 in Candida albicans.
Wong KH, et al. (2007 Oct). Transcriptional control of nmrA by the bZIP transcription factor MeaB reveals a new level of nitrogen regulation in Aspergillus nidulans.
Kanda S, et al. (2008). Ambient pH signaling regulates expression of the serine protease gene (spr1) in pine wilt nematode-trapping fungus, Monacrosporium megalosporum.
Liao WL, et al. (2008 Apr). GLN3 encodes a global regulator of nitrogen metabolism and virulence of C. albicans.
Dabas N, et al. (2008 Aug). A transcription factor regulatory cascade controls secreted aspartic protease expression in Candida albicans.
Kotaka M, et al. (2008 Aug 29). Structural analysis of the recognition of the negative regulator NmrA and DNA by the zinc finger from the GATA-type transcription factor AreA.
Wang Y, et al. (2008 Feb). Nitrite transport is mediated by the nitrite-specific high-affinity NitA transporter and by nitrate transporters NrtA, NrtB in Aspergillus nidulans.
Katz ME, et al. (2008 Jul). The interaction of induction, repression and starvation in the regulation of extracellular proteases in Aspergillus nidulans: evidence for a role for CreA in the response to carbon starvation.
Oestreicher N, et al. (2008 May). The nadA gene of Aspergillus nidulans, encoding adenine deaminase, is subject to a unique regulatory pattern.
Vlanti A, et al. (2008 May). The Aspergillus nidulans FcyB cytosine-purine scavenger is highly expressed during germination and in reproductive compartments and is downregulated by endocytosis.
Berger H, et al. (2008 Sep). Dissecting individual steps of nitrogen transcription factor cooperation in the Aspergillus nidulans nitrate cluster.
Basheer A, et al. (2009 Apr). A library-based method to rapidly analyse chromatin accessibility at multiple genomic regions.
Wong KH, et al. (2009 Dec). Deletion and overexpression of the Aspergillus nidulans GATA factor AreB reveals unexpected pleiotropy.
Bastidas RJ, et al. (2009 Feb). The protein kinase Tor1 regulates adhesin gene expression in Candida albicans.
Apostolaki A, et al. (2009 Mar). AgtA, the dicarboxylic amino acid transporter of Aspergillus nidulans, is concertedly down-regulated by exquisite sensitivity to nitrogen metabolite repression and ammonium-elicited endocytosis.
Abreu C, et al. (2010 Dec). UreA, the major urea/H+ symporter in Aspergillus nidulans.
Zhao X, et al. (2010 Jul). The transcription repressor NmrA is subject to proteolysis by three Aspergillus nidulans proteases.
Kmetzsch L, et al. (2011 Feb). The GATA-type transcriptional activator Gat1 regulates nitrogen uptake and metabolism in the human pathogen Cryptococcus neoformans.
Navarathna DH, et al. (2011 Jan). Dur3 is the major urea transporter in Candida albicans and is co-regulated with the urea amidolyase Dur1,2.
Chen YT, et al. (2012 Feb). Rhb1 regulates the expression of secreted aspartic protease 2 through the TOR signaling pathway in Candida albicans.
Bayram O, et al. (2012 Jan). Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins.
Macios M, et al. (2012 Mar). The GATA factors AREA and AREB together with the co-repressor NMRA, negatively regulate arginine catabolism in Aspergillus nidulans in response to nitrogen and carbon source.
Georgakopoulos P, et al. (2012 Nov). SAGA complex components and acetate repression in Aspergillus nidulans.
Krol K, et al. (2013 Sep). RrmA regulates the stability of specific transcripts in response to both nitrogen source and oxidative stress.
Tudzynski B, et al. (2014). Nitrogen regulation of fungal secondary metabolism in fungi.
Hunter CC, et al. (2014 Apr). Multiple nuclear localization signals mediate nuclear localization of the GATA transcription factor AreA.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
||
FOG03358
EOG8JSXQ1
sce:absent
Genes: 26
EOG8JSXQ1
sce:absent
Genes: 26
PomBase Description
iron-sensing transcription factor Fep1|transcription factor, zf-GATA type (predicted)
AspGD Description
Ortholog(s) have sequence-specific DNA binding activity and role in cellular iron ion homeostasis, negative regulation of iron ion transport, siderophore biosynthetic process
References
Haas H, et al. (1999 Feb 19). The Aspergillus nidulans GATA factor SREA is involved in regulation of siderophore biosynthesis and control of iron uptake.
Oberegger H, et al. (2000 Nov 24). Iron starvation leads to increased expression of Cu/Zn-superoxide dismutase in Aspergillus.
Tani S, et al. (2001 Feb). Characterization of the amyR gene encoding a transcriptional activator for the amylase genes in Aspergillus nidulans.
Oberegger H, et al. (2001 Sep). SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulans.
Oberegger H, et al. (2002 Aug). Identification of members of the Aspergillus nidulans SREA regulon: genes involved in siderophore biosynthesis and utilization.
Oberegger H, et al. (2002 Nov). Regulation of freA, acoA, lysF, and cycA expression by iron availability in Aspergillus nidulans.
Haas H, et al. (2003 Apr 15). Characterization of the Aspergillus nidulans transporters for the siderophores enterobactin and triacetylfusarinine C.
Oberegger H, et al. (2003 Dec). 4'-phosphopantetheinyl transferase-encoding npgA is essential for siderophore biosynthesis in Aspergillus nidulans.
Haas H, et al. (2003 Sep). Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage.
Lan CY, et al. (2004 Sep). Regulatory networks affected by iron availability in Candida albicans.
Eisendle M, et al. (2006 Oct). The intracellular siderophore ferricrocin is involved in iron storage, oxidative-stress resistance, germination, and sexual development in Aspergillus nidulans.
Hortschansky P, et al. (2007 Jul 11). Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron.
Woodacre A, et al. (2008 May). Copper-dependent transcriptional regulation by Candida albicans Mac1p.
Thön M, et al. (2010 Mar). The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes.
Chen C, et al. (2011 Aug 18). An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis.
Hsu PC, et al. (2011 Feb). Candida albicans Hap43 is a repressor induced under low-iron conditions and is essential for iron-responsive transcriptional regulation and virulence.
Singh RP, et al. (2011 Jul 15). Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.
Chen C, et al. (2012). Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host.
Colabardini AC, et al. (2013). Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK.
Franken AC, et al. (2014 Nov). Genome mining and functional genomics for siderophore production in Aspergillus niger.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03359
EOG8JSXQ1
sce:GLN3
Genes: 23
EOG8JSXQ1
sce:GLN3
Genes: 23
SGD Description
Transcriptional activator of genes regulated by nitrogen catabolite repression; localization and activity regulated by quality of nitrogen source and Ure2p
References
Minehart PL, et al. (1991 Dec). Sequence and expression of GLN3, a positive nitrogen regulatory gene of Saccharomyces cerevisiae encoding a protein with a putative zinc finger DNA-binding domain.
Piskacek S, et al. (2007 Jun). Nine-amino-acid transactivation domain: establishment and prediction utilities.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03360
EOG8JSXQ1
sce:absent
Genes: 7
EOG8JSXQ1
sce:absent
Genes: 7
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03361
EOG8JSXQ1
sce:absent
Genes: 2
EOG8JSXQ1
sce:absent
Genes: 2
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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