FOG03338
EOG8N8PQH

sce:HAP5

Genes: 33

SGD Description
Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex


PomBase Description
CCAAT-binding factor complex subunit Php5


References

van Heeswijck R, et al. (1991 May 25). The amdR product and a CCAAT-binding factor bind to adjacent, possibly overlapping DNA sequences in the promoter region of the Aspergillus nidulans amdS gene.

McNabb DS, et al. (1995 Jan 1). Cloning of yeast HAP5: a novel subunit of a heterotrimeric complex required for CCAAT binding.

McNabb DS, et al. (1997 Dec). The Saccharomyces cerevisiae Hap5p homolog from fission yeast reveals two conserved domains that are essential for assembly of heterotetrameric CCAAT-binding factor.

Steidl S, et al. (1999 Jan). AnCF, the CCAAT binding complex of Aspergillus nidulans, contains products of the hapB, hapC, and hapE genes and is required for activation by the pathway-specific regulatory gene amdR.

Brakhage AA, et al. (1999 Jul-Aug). HAP-Like CCAAT-binding complexes in filamentous fungi: implications for biotechnology.

Narendja FM, et al. (1999 Oct). AnCF, the CCAAT binding complex of Aspergillus nidulans, is essential for the formation of a DNase I-hypersensitive site in the 5' region of the amdS gene.

Li Y, et al. (2001 Aug 10). A multiprotein complex that interacts with RNA polymerase II elongator.

Tsukagoshi N, et al. (2001 Feb). Regulation of the amylolytic and (hemi-)cellulolytic genes in aspergilli.

Weidner G, et al. (2001 Feb). The Aspergillus nidulans homoaconitase gene lysF is negatively regulated by the multimeric CCAAT-binding complex AnCF and positively regulated by GATA sites.

Steidl S, et al. (2001 Mar 2). The Aspergillus nidulans multimeric CCAAT binding complex AnCF is negatively autoregulated via its hapB subunit gene.

Tanaka A, et al. (2001 May). AoHapB, AoHapC and AoHapE, subunits of the Aspergillus oryzae CCAAT-binding complex, are functionally interchangeable with the corresponding subunits in Aspergillus nidulans.

Zeilinger S, et al. (2001 Sep). The Hypocrea jecorina HAP 2/3/5 protein complex binds to the inverted CCAAT-box (ATTGG) within the cbh2 (cellobiohydrolase II-gene) activating element.

Kato M, et al. (2002 Feb 13). A quantity control mechanism regulating levels of the HapE subunit of the Hap complex in Aspergillus nidulans: no accumulation of HapE in hapC deletion mutants.

Tanaka A, et al. (2002 Jun 7). Isolation of genes encoding novel transcription factors which interact with the Hap complex from Aspergillus species.

Brakhage AA, et al. (2004). Regulation of penicillin biosynthesis in filamentous fungi.

Steidl S, et al. (2004 Sep 10). A single subunit of a heterotrimeric CCAAT-binding complex carries a nuclear localization signal: piggy back transport of the pre-assembled complex to the nucleus.

Kato M, et al. (2005 Apr). An overview of the CCAAT-box binding factor in filamentous fungi: assembly, nuclear translocation, and transcriptional enhancement.

Goda H, et al. (2005 Nov). Nuclear translocation of the heterotrimeric CCAAT binding factor of Aspergillus oryzae is dependent on two redundant localising signals in a single subunit.

McNabb DS, et al. (2005 Nov). Assembly of the Hap2p/Hap3p/Hap4p/Hap5p-DNA complex in Saccharomyces cerevisiae.

Tüncher A, et al. (2005 Sep 23). The CCAAT-binding complex of eukaryotes: evolution of a second NLS in the HapB subunit of the filamentous fungus Aspergillus nidulans despite functional conservation at the molecular level between yeast, A.nidulans and human.

Tanoue S, et al. (2006 Apr). The region in a subunit of the Aspergillus CCAAT-binding protein similar to the HAP4p-recruiting domain of Saccharomyces cerevisiae Hap5p is not essential for transcriptional enhancement.

Spröte P, et al. (2008 Oct). Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster.

Brakhage AA, et al. (2009 Oct-Nov). Aspects on evolution of fungal beta-lactam biosynthesis gene clusters and recruitment of trans-acting factors.

Thön M, et al. (2010 Mar). The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Huber EM, et al. (2012 Oct 10). DNA minor groove sensing and widening by the CCAAT-binding complex.

Hortschansky P, et al. (2015 Mar 6). Deciphering the combinatorial DNA-binding code of the CCAAT-binding complex and the iron-regulatory basic region leucine zipper (bZIP) transcription factor HapX.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03339
EOG8N8PQH

sce:BUR6

Genes: 32

SGD Description
Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p


PomBase Description
DNA polymerase epsilon interactor Dpb3-like


AspGD Description
Has domain(s) with predicted protein heterodimerization activity, sequence-specific DNA binding activity and intracellular localization


References

Goppelt A, et al. (1996 Nov 15). Characterization of the basal inhibitor of class II transcription NC2 from Saccharomyces cerevisiae.

Gadbois EL, et al. (1997 Apr 1). Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo.

Kim S, et al. (1997 Feb 4). The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo.

Cang Y, et al. (2002 Oct 1). Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP).

Spiga MG, et al. (2004). Identification and cloning of two putative subunits of DNA polymerase epsilon in fission yeast.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03340
EOG8N8PQH

sce:absent

Genes: 19

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG03341
EOG8N8PQH

sce:absent

Genes: 5

AspGD Description
Has domain(s) with predicted protein heterodimerization activity, sequence-specific DNA binding activity and intracellular localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03342
EOG8N8PQH
EOG8P8D4K

sce:DLS1

Genes: 5

SGD Description
Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication


References

Guiard B, et al. (1976). Complete amino acid sequence of the heme-binding core in bakers' yeast cytochrome b2 (L-(+)-lactate dehydrogenase).

Goldmark JP, et al. (2000 Oct 27). The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p.

Gelbart ME, et al. (2001 Mar). Interactions of Isw2 chromatin remodeling complex with nucleosomal arrays: analyses using recombinant yeast histones and immobilized templates.

Fazzio TG, et al. (2001 Oct). Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression.

Sugiyama M, et al. (2001 Sep). The Saccharomyces cerevisiae Isw2p-Itc1p complex represses INO1 expression and maintains cell morphology.

McConnell AD, et al. (2004 Apr). Histone fold protein Dls1p is required for Isw2-dependent chromatin remodeling in vivo.

Iida T, et al. (2004 Jan). Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03343
EOG8N8PQH

sce:DPB3

Genes: 3

SGD Description
Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication


PomBase Description
DNA polymerase epsilon Dpb3 (predicted)


References

Araki H, et al. (1991 Sep 25). Cloning DPB3, the gene encoding the third subunit of DNA polymerase II of Saccharomyces cerevisiae.

Ohya T, et al. (2000 Oct 15). Structure and function of the fourth subunit (Dpb4p) of DNA polymerase epsilon in Saccharomyces cerevisiae.

Shimizu K, et al. (2002 Oct 4). Fidelity of DNA polymerase epsilon holoenzyme from budding yeast Saccharomyces cerevisiae.

Chilkova O, et al. (2003 Apr 18). The quaternary structure of DNA polymerase epsilon from Saccharomyces cerevisiae.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%