FOG03284
EOG8W6MC8

sce:SLM1;SLM2

Genes: 35

SGD Description
Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication|Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication


AspGD Description
Ortholog(s) have phosphatidylinositol-4,5-bisphosphate binding, sphingolipid binding activity


References

Yu JW, et al. (2004 Mar 12). Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains.

Audhya A, et al. (2004 Oct 1). Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.

Fadri M, et al. (2005 Apr). The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.

Zhang Z, et al. (2005 Aug). Identification and characterization of upstream open reading frames (uORF) in the 5' untranslated regions (UTR) of genes in Saccharomyces cerevisiae.

Bultynck G, et al. (2006 Jun). Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease.

Mulet JM, et al. (2006 Nov 3). Mutual antagonism of target of rapamycin and calcineurin signaling.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03285
EOG8W6MC8

sce:absent

Genes: 18

PomBase Description
cytoskeletal signaling protein Slm1 (predicted)


AspGD Description
Ortholog(s) have cell cortex of cell tip localization


References

Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Kabeche R, et al. (2011 Nov). The filament-forming protein Pil1 assembles linear eisosomes in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03286
EOG8W6MC8

sce:ASK10;RGC1

Genes: 9

SGD Description
Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication|Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication


References

Page N, et al. (1996 Mar 15). Identification of ASK10 as a multicopy activator of Skn7p-dependent transcription of a HIS3 reporter gene.

Zettel MF, et al. (2003 Jun 27). The budding index of Saccharomyces cerevisiae deletion strains identifies genes important for cell cycle progression.

Cohen TJ, et al. (2003 Oct). Ask10p mediates the oxidative stress-induced destruction of the Saccharomyces cerevisiae C-type cyclin Ume3p/Srb11p.

Yu JW, et al. (2004 Mar 12). Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Beese SE, et al. (2009 Nov). Identification of positive regulators of the yeast fps1 glycerol channel.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03287
EOG8W6MC8

sce:absent

Genes: 7

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03288
EOG8W6MC8

sce:absent

Genes: 7

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03289
EOG8W6MC8

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%