FOG03204
EOG8PRR8D

sce:PRE5

Genes: 34

SGD Description
Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress


PomBase Description
20S proteasome complex subunit alpha 6 subunit Pre5 (predicted)


AspGD Description
20S CP alpha subunit of the proteasome


References

Heinemeyer W, et al. (1994 Oct 11). PRE5 and PRE6, the last missing genes encoding 20S proteasome subunits from yeast? Indication for a set of 14 different subunits in the eukaryotic proteasome core.

Groll M, et al. (1997 Apr 3). Structure of 20S proteasome from yeast at 2.4 A resolution.

Groll M, et al. (2000 Nov). A gated channel into the proteasome core particle.

Whitby FG, et al. (2000 Nov 2). Structural basis for the activation of 20S proteasomes by 11S regulators.

Groll M, et al. (2006 Apr 19). Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.

Groll M, et al. (2006 Jun). TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome.

Groll M, et al. (2006 Mar). Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.

Sadre-Bazzaz K, et al. (2010 Mar 12). Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03205
EOG8PRR8D

sce:PRE6

Genes: 33

SGD Description
Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress


PomBase Description
20S proteasome complex subunit alpha 4 Pre6


AspGD Description
20S CP alpha subunit of the proteasome


References

Kubota S, et al. (1977 Jan). Studies on the microsomal electron-transport system of anaerobically grown yeast. IV. Purification and characterization of NADH-cytochrome b5 reductase.

Heinemeyer W, et al. (1994 Oct 11). PRE5 and PRE6, the last missing genes encoding 20S proteasome subunits from yeast? Indication for a set of 14 different subunits in the eukaryotic proteasome core.

Groll M, et al. (1997 Apr 3). Structure of 20S proteasome from yeast at 2.4 A resolution.

Groll M, et al. (2000 Nov). A gated channel into the proteasome core particle.

Whitby FG, et al. (2000 Nov 2). Structural basis for the activation of 20S proteasomes by 11S regulators.

Jäger S, et al. (2001 Aug 15). Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4.

Groll M, et al. (2001 Aug 17). Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor.

Groll M, et al. (2006 Apr 19). Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.

Groll M, et al. (2006 Jun). TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome.

Groll M, et al. (2006 Mar). Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.

Lee SC, et al. (2007 Feb). A novel interaction between N-myristoylation and the 26S proteasome during cell morphogenesis.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Sadre-Bazzaz K, et al. (2010 Mar 12). Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03206
EOG8PRR8D

sce:PUP2

Genes: 33

SGD Description
Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta


PomBase Description
20S proteasome complex subunit alpha 5, Pup2 (predicted)


AspGD Description
20S CP alpha subunit of the proteasome


References

Kubota S, et al. (1977 Jan). Studies on the microsomal electron-transport system of anaerobically grown yeast. IV. Purification and characterization of NADH-cytochrome b5 reductase.

Georgatsou E, et al. (1992 Mar 24). Molecular cloning of an essential yeast gene encoding a proteasomal subunit.

Chen P, et al. (1995 Jun 1). Biogenesis, structure and function of the yeast 20S proteasome.

Groll M, et al. (1997 Apr 3). Structure of 20S proteasome from yeast at 2.4 A resolution.

Groll M, et al. (2000 Nov). A gated channel into the proteasome core particle.

Whitby FG, et al. (2000 Nov 2). Structural basis for the activation of 20S proteasomes by 11S regulators.

Groll M, et al. (2001 Aug 17). Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor.

Groll M, et al. (2006 Apr 19). Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.

Groll M, et al. (2006 Jun). TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome.

Groll M, et al. (2006 Mar). Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Paul SK, et al. (2009 Sep). A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.

Bohn S, et al. (2010 Dec 7). Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution.

Takeda K, et al. (2010 Feb 23). Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

Sadre-Bazzaz K, et al. (2010 Mar 12). Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.

Kouranti I, et al. (2010 Sep 7). A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03207
EOG8PRR8D

sce:PRE8

Genes: 33

SGD Description
Alpha 2 subunit of the 20S proteasome


PomBase Description
20S proteasome complex subunit alpha 2, Pre8 (predicted)


AspGD Description
20S CP alpha subunit of the proteasome


References

Emori Y, et al. (1991 Jan). Molecular cloning and functional analysis of three subunits of yeast proteasome.

Groll M, et al. (1997 Apr 3). Structure of 20S proteasome from yeast at 2.4 A resolution.

Groll M, et al. (2000 Nov). A gated channel into the proteasome core particle.

Whitby FG, et al. (2000 Nov 2). Structural basis for the activation of 20S proteasomes by 11S regulators.

Groll M, et al. (2006 Apr 19). Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.

Groll M, et al. (2006 Jun). TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome.

Groll M, et al. (2006 Mar). Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.

Sato I, et al. (2009 Mar 20). The glutathione system of Aspergillus nidulans involves a fungus-specific glutathione S-transferase.

Bohn S, et al. (2010 Dec 7). Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution.

Takeda K, et al. (2010 Feb 23). Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

Sadre-Bazzaz K, et al. (2010 Mar 12). Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.

Kouranti I, et al. (2010 Sep 7). A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Pathare GR, et al. (2012 Jan 3). The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together.

Lasker K, et al. (2012 Jan 31). Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03208
EOG8PRR8D

sce:PRE9

Genes: 33

SGD Description
Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform


PomBase Description
20S proteasome complex subunit alpha 3 Pre9 (predicted)


AspGD Description
20S CP alpha subunit of the proteasome


References

Emori Y, et al. (1991 Jan). Molecular cloning and functional analysis of three subunits of yeast proteasome.

Groll M, et al. (1997 Apr 3). Structure of 20S proteasome from yeast at 2.4 A resolution.

Groll M, et al. (2000 Nov). A gated channel into the proteasome core particle.

Whitby FG, et al. (2000 Nov 2). Structural basis for the activation of 20S proteasomes by 11S regulators.

Hitchcock AL, et al. (2003 Oct 28). A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.

Groll M, et al. (2006 Apr 19). Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.

Groll M, et al. (2006 Jun). TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome.

Groll M, et al. (2006 Mar). Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.

Lee SC, et al. (2007 Feb). A novel interaction between N-myristoylation and the 26S proteasome during cell morphogenesis.

Sadre-Bazzaz K, et al. (2010 Mar 12). Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03209
EOG8PRR8D

sce:PRE10

Genes: 33

SGD Description
Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress


PomBase Description
20S proteasome complex subunit alpha 7, Pre10 (predicted)


AspGD Description
20S CP alpha subunit of the proteasome


References

Fujiwara T, et al. (1990 Sep 25). Proteasomes are essential for yeast proliferation. cDNA cloning and gene disruption of two major subunits.

Groll M, et al. (1997 Apr 3). Structure of 20S proteasome from yeast at 2.4 A resolution.

Groll M, et al. (2000 Nov). A gated channel into the proteasome core particle.

Whitby FG, et al. (2000 Nov 2). Structural basis for the activation of 20S proteasomes by 11S regulators.

Groll M, et al. (2006 Apr 19). Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.

Groll M, et al. (2006 Jun). TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome.

Groll M, et al. (2006 Mar). Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.

Lee SC, et al. (2007 Feb). A novel interaction between N-myristoylation and the 26S proteasome during cell morphogenesis.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Bohn S, et al. (2010 Dec 7). Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution.

Takeda K, et al. (2010 Feb 23). Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

Sadre-Bazzaz K, et al. (2010 Mar 12). Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.

Kouranti I, et al. (2010 Sep 7). A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Lasker K, et al. (2012 Jan 31). Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.

Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03210
EOG8PRR8D

sce:SCL1

Genes: 33

SGD Description
Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria


PomBase Description
20S proteasome complex subunit alpha 1 (predicted)


AspGD Description
20S CP alpha subunit of the proteasome


References

Kubota S, et al. (1977 Jan). Studies on the microsomal electron-transport system of anaerobically grown yeast. IV. Purification and characterization of NADH-cytochrome b5 reductase.

Balzi E, et al. (1989 Nov 30). The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for growth.

Fujiwara T, et al. (1990 Sep 25). Proteasomes are essential for yeast proliferation. cDNA cloning and gene disruption of two major subunits.

Emori Y, et al. (1991 Jan). Molecular cloning and functional analysis of three subunits of yeast proteasome.

Groll M, et al. (1997 Apr 3). Structure of 20S proteasome from yeast at 2.4 A resolution.

Groll M, et al. (2000 Nov). A gated channel into the proteasome core particle.

Whitby FG, et al. (2000 Nov 2). Structural basis for the activation of 20S proteasomes by 11S regulators.

Jäger S, et al. (2001 Aug 15). Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4.

Groll M, et al. (2001 Aug 17). Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor.

Groll M, et al. (2006 Apr 19). Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.

Groll M, et al. (2006 Jun). TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome.

Groll M, et al. (2006 Mar). Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.

Hortschansky P, et al. (2007 Jul 11). Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron.

Sadre-Bazzaz K, et al. (2010 Mar 12). Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%