FOG03146
EOG85B015

sce:DJP1;CAJ1

Genes: 60

SGD Description
Cytosolic J-domain-containing protein; required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ|Nuclear type II J heat shock protein of the E. coli dnaJ family; contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly


PomBase Description
DNAJ domain protein Caj1/Djp1 type (predicted)|DNAJ protein Caj1/Djp1-type (predicted)


AspGD Description
Ortholog(s) have cell division site, cell tip, cytosol localization


References

Guiard B, et al. (1976). Complete amino acid sequence of the heme-binding core in bakers' yeast cytochrome b2 (L-(+)-lactate dehydrogenase).

Elgersma Y, et al. (1993 Nov). An efficient positive selection procedure for the isolation of peroxisomal import and peroxisome assembly mutants of Saccharomyces cerevisiae.

Mukai H, et al. (1994 Jul 22). Isolation and characterization of CAJ1, a novel yeast homolog of dnaJ.

Hettema EH, et al. (1998 Jul 27). The cytosolic DnaJ-like protein djp1p is involved specifically in peroxisomal protein import.

Lu JM, et al. (2004 Dec). Role for the Ran binding protein, Mog1p, in Saccharomyces cerevisiae SLN1-SKN7 signal transduction.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mathiassen SG, et al. (2015 Aug 21). A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03147
EOG85B015

sce:JJJ1

Genes: 34

SGD Description
Co-chaperone that stimulates the ATPase activity of Ssa1p; required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis


PomBase Description
Co-chaperone for ATPase activity (predicted)

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03148
EOG85B015

sce:JAC1

Genes: 32

SGD Description
Specialized J-protein that functions in Fe-S cluster biogenesis; functions with Hsp70 in Fe-S cluster biogenesis in mitochondria; involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix


PomBase Description
mitochondrial DNAJ domain protein Jac1 (predicted)


AspGD Description
Ortholog(s) have chaperone binding activity, role in aerobic respiration, iron-sulfur cluster assembly and mitochondrion localization


References

Strain J, et al. (1998 Nov 20). Suppressors of superoxide dismutase (SOD1) deficiency in Saccharomyces cerevisiae. Identification of proteins predicted to mediate iron-sulfur cluster assembly.

Voisine C, et al. (2001 Feb 13). Jac1, a mitochondrial J-type chaperone, is involved in the biogenesis of Fe/S clusters in Saccharomyces cerevisiae.

Lutz T, et al. (2001 Mar 30). The mitochondrial proteins Ssq1 and Jac1 are required for the assembly of iron sulfur clusters in mitochondria.

Kim R, et al. (2001 May 18). J-domain protein, Jac1p, of yeast mitochondria required for iron homeostasis and activity of Fe-S cluster proteins.

Dutkiewicz R, et al. (2003 Aug 8). Ssq1, a mitochondrial Hsp70 involved in iron-sulfur (Fe/S) center biogenesis. Similarities to and differences from its bacterial counterpart.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Mühlenhoff U, et al. (2003 Sep 15). Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p.

Dutkiewicz R, et al. (2004 Jul 9). Sequence-specific interaction between mitochondrial Fe-S scaffold protein Isu and Hsp70 Ssq1 is essential for their in vivo function.

Dutkiewicz R, et al. (2006 Mar 24). The Hsp70 chaperone Ssq1p is dispensable for iron-sulfur cluster formation on the scaffold protein Isu1p.

Andrew AJ, et al. (2006 May 26). Characterization of the interaction between the J-protein Jac1p and the scaffold for Fe-S cluster biogenesis, Isu1p.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Delewski W, et al. (2016 Mar). Iron-Sulfur Cluster Biogenesis Chaperones: Evidence for Emergence of Mutational Robustness of a Highly Specific Protein-Protein Interaction.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03149
EOG85B015

sce:absent

Genes: 28

PomBase Description
DNAJ domain protein, DNAJC9 family (predicted)


AspGD Description
Ortholog(s) have nucleolus localization


References

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Chen Z, et al. (2012 Oct). A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03150
EOG85B015

sce:JJJ3

Genes: 23

SGD Description
Protein of unknown function; contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4


References

Walsh P, et al. (2004 Jun). The J-protein family: modulating protein assembly, disassembly and translocation.

Liu S, et al. (2004 Nov). Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03151
EOG85B015
EOG8NP5MV
EOG8RBP43

sce:absent

Genes: 22

PomBase Description
DNAJ domain protein Cwf23


AspGD Description
Ortholog(s) have nucleolus localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03152
EOG85B015

sce:JEM1

Genes: 5

SGD Description
DnaJ-like chaperone required for nuclear membrane fusion during mating; localizes to the ER membrane; exhibits genetic interactions with KAR2


References

Guiard B, et al. (1976). Complete amino acid sequence of the heme-binding core in bakers' yeast cytochrome b2 (L-(+)-lactate dehydrogenase).

Nishikawa S, et al. (1997 May 16). The yeast JEM1p is a DnaJ-like protein of the endoplasmic reticulum membrane required for nuclear fusion.

Nishikawa S, et al. (2003 Mar 14). Nep98p is a component of the yeast spindle pole body and essential for nuclear division and fusion.

Sundin BA, et al. (2004 Jul 15). Localization of proteins that are coordinately expressed with Cln2 during the cell cycle.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03153
EOG85B015

sce:absent

Genes: 2

PomBase Description
Hsp70 protein binding protein Mug184

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%