FOG03121
EOG8P8D15

sce:HOC1

Genes: 30

SGD Description
Alpha-1,6-mannosyltransferase; involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele


AspGD Description
Putative alpha-1,6-mannosyltransferase; expression enhanced by maltose


References

Hashimoto H, et al. (1997 Dec 29). Novel membrane protein complexes for protein glycosylation in the yeast Golgi apparatus.

Neiman AM, et al. (1997 Mar). Saccharomyces cerevisiae HOC1, a suppressor of pkc1, encodes a putative glycosyltransferase.

Jungmann J, et al. (1998 Jan 15). Multi-protein complexes in the cis Golgi of Saccharomyces cerevisiae with alpha-1,6-mannosyltransferase activity.

Miskei M, et al. (2009 Mar). Annotation of stress-response proteins in the aspergilli.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 9 genes with posterior transmembrane prediction > 50%

FOG03122
EOG8P8D15

sce:OCH1

Genes: 27

SGD Description
Mannosyltransferase of the cis-Golgi apparatus; initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins


PomBase Description
alpha-1,6-mannosyltransferase Och1


References

Nagasu T, et al. (1992 Jul). Isolation of new temperature-sensitive mutants of Saccharomyces cerevisiae deficient in mannose outer chain elongation.

Nakayama K, et al. (1992 Jul). OCH1 encodes a novel membrane bound mannosyltransferase: outer chain elongation of asparagine-linked oligosaccharides.

Nakanishi-Shindo Y, et al. (1993 Dec 15). Structure of the N-linked oligosaccharides that show the complete loss of alpha-1,6-polymannose outer chain from och1, och1 mnn1, and och1 mnn1 alg3 mutants of Saccharomyces cerevisiae.

Lehle L, et al. (1995 Aug 14). Glycoprotein biosynthesis in Saccharomyces cerevisiae: ngd29, an N-glycosylation mutant allelic to och1 having a defect in the initiation of outer chain formation.

Harris SL, et al. (1996 Mar). Localization of a yeast early Golgi mannosyltransferase, Och1p, involves retrograde transport.

Horecka J, et al. (2000). Use of imidazoleglycerolphosphate dehydratase (His3) as a biological reporter in yeast.

Cullen PJ, et al. (2000 Jul). Defects in protein glycosylation cause SHO1-dependent activation of a STE12 signaling pathway in yeast.

Yoko-o T, et al. (2001 Jan 26). Schizosaccharomyces pombe och1(+) encodes alpha-1,6-mannosyltransferase that is involved in outer chain elongation of N-linked oligosaccharides.

Li S, et al. (2002 Feb). The eukaryotic two-component histidine kinase Sln1p regulates OCH1 via the transcription factor, Skn7p.

Cui Z, et al. (2002 Jan 15). Cdc4 is involved in the transcriptional control of OCH1, a gene encoding alpha-1,6-mannosyltransferase in Saccharomyces cerevisiae.

Karhinen L, et al. (2004 Jan 15). Activity of recycling Golgi mannosyltransferases in the yeast endoplasmic reticulum.

Bruinsma P, et al. (2004 Sep 17). Retrograde transport of the mannosyltransferase Och1p to the early Golgi requires a component of the COG transport complex.

Bates S, et al. (2006 Jan 6). Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans.

Netea MG, et al. (2006 Jun). Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors.

Kitajima T, et al. (2006 Nov). Saccharomyces cerevisiae alpha1,6-mannosyltransferase has a catalytic potential to transfer a second mannose molecule.

Rida PC, et al. (2006 Oct). Yeast-to-hyphal transition triggers formin-dependent Golgi localization to the growing tip in Candida albicans.

Fradin C, et al. (2008 Oct). Beta-1,2 oligomannose adhesin epitopes are widely distributed over the different families of Candida albicans cell wall mannoproteins and are associated through both N- and O-glycosylation processes.

van de Veerdonk FL, et al. (2009 Apr 1). Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans.

Ohashi T, et al. (2009 Feb). The och1 mutant of Schizosaccharomyces pombe produces galactosylated core structures of N-linked oligosaccharides.

Ohashi T, et al. (2010 Mar). N- and O-linked oligosaccharides completely lack galactose residues in the gms1och1 mutant of Schizosaccharomyces pombe.

Ohashi T, et al. (2010 Nov). Production of heterologous glycoproteins by a glycosylation-defective alg3och1 mutant of Schizosaccharomyces pombe.

Chantret I, et al. (2011 Dec 2). Endoplasmic reticulum-associated degradation (ERAD) and free oligosaccharide generation in Saccharomyces cerevisiae.

Sheth CC, et al. (2011 Jul). Glycosylation status of the C. albicans cell wall affects the efficiency of neutrophil phagocytosis and killing but not cytokine signaling.

Hirayama H, et al. (2011 Oct). Metabolism of free oligosaccharides is facilitated in the och1Δ mutant of Saccharomyces cerevisiae.

Ohashi T, et al. (2012 Nov 9). Identification of novel α1,3-galactosyltransferase and elimination of α-galactose-containing glycans by disruption of multiple α-galactosyltransferase genes in Schizosaccharomyces pombe.

Shahana S, et al. (2013 Jul). Reporters for the analysis of N-glycosylation in Candida albicans.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Chen JS, et al. (2016 Sep). Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 17 genes with posterior transmembrane prediction > 50%

FOG03123
EOG8P8D15

sce:absent

Genes: 10

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG03124
EOG8P8D15

sce:absent

Genes: 6

AspGD Description
Putative alpha-1,6-Mannosyltransferase; induced by caspofungin|Ortholog of A. nidulans FGSC A4 : AN2626, AN1620, A. fumigatus Af293 : Afu8g02040/och3, A. niger CBS 513.88 : An03g01090/hocA and A. oryzae RIB40 : AO090010000615

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03125
EOG8P8D15

sce:absent

Genes: 4

AspGD Description
Ortholog of A. fumigatus Af293 : Afu6g14040/och2, A. oryzae RIB40 : AO090003001503, Neosartorya fischeri NRRL 181 : NFIA_059930 and Aspergillus niger ATCC 1015 : 189528-mRNA

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG03126
EOG8P8D15

sce:absent

Genes: 3

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG03127
EOG8P8D15

sce:absent

Genes: 2

AspGD Description
Protein of unknown function|Ortholog of A. nidulans FGSC A4 : AN7534, A. fumigatus Af293 : Afu1g01380/och4, A. niger CBS 513.88 : An14g07140, Aspergillus versicolor : Aspve1_0085820 and Aspergillus clavatus NRRL 1 : ACLA_033030

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03128
EOG8P8D15

sce:absent

Genes: 5

AspGD Description
Ortholog of A. nidulans FGSC A4 : AN7534, A. fumigatus Af293 : Afu1g01380/och4, A. niger CBS 513.88 : An12g07020, Aspergillus versicolor : Aspve1_0085820 and Aspergillus clavatus NRRL 1 : ACLA_033030

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%