FOG02842
EOG8RV17C

sce:TIF1; TIF2

Genes: 34

PomBase Description
translation initiation factor eIF4A (predicted)


AspGD Description
Ortholog(s) have cytosol localization


References

Linder P, et al. (1988 Nov 11). Sequence of the genes TIF1 and TIF2 from Saccharomyces cerevisiae coding for a translation initiation factor.

Linder P, et al. (1989 Apr). An essential yeast protein, encoded by duplicated genes TIF1 and TIF2 and homologous to the mammalian translation initiation factor eIF-4A, can suppress a mitochondrial missense mutation.

Blum S, et al. (1989 Aug). Translation in Saccharomyces cerevisiae: initiation factor 4A-dependent cell-free system.

Altmann M, et al. (1990 Aug 27). Translation initiation factor-dependent extracts from Saccharomyces cerevisiae.

Schmid SR, et al. (1991 Jul). Translation initiation factor 4A from Saccharomyces cerevisiae: analysis of residues conserved in the D-E-A-D family of RNA helicases.

Foreman PK, et al. (1991 May 25). The Saccharomyces cerevisiae RPB4 gene is tightly linked to the TIF2 gene.

Blum S, et al. (1992 Aug 15). ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae.

Smiley JK, et al. (1992 Sep 25). The 66 kDa component of yeast SFI, stimulatory factor I, is hsp60.

Cheng C, et al. (1995 Dec). Requirement of the self-glucosylating initiator proteins Glg1p and Glg2p for glycogen accumulation in Saccharomyces cerevisiae.

Mirbod F, et al. (1996 Nov-Dec). Molecular cloning of a gene encoding translation initiation factor (TIF) from Candida albicans.

Garrels JI, et al. (1997 Aug). Proteome studies of Saccharomyces cerevisiae: identification and characterization of abundant proteins.

Neff CL, et al. (1999 Aug). Eukaryotic translation initiation factors 4G and 4A from Saccharomyces cerevisiae interact physically and functionally.

Johnson ER, et al. (1999 Dec). Crystallographic structure of the amino terminal domain of yeast initiation factor 4A, a representative DEAD-box RNA helicase.

Benz J, et al. (1999 Jun 15). Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family.

Daga RR, et al. (1999 Sep). Translational control of the cdc25 cell cycle phosphatase: a molecular mechanism coupling mitosis to cell growth.

Dominguez D, et al. (1999 Sep 17). Interaction of translation initiation factor eIF4G with eIF4A in the yeast Saccharomyces cerevisiae.

Caruthers JM, et al. (2000 Nov 21). Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase.

Tanner NK, et al. (2003 Jan). The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Oh YT, et al. (2010 Mar). Proteomic analysis of early phase of conidia germination in Aspergillus nidulans.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Ren L, et al. (2011 Feb 28). Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02843
EOG8RV17C

sce:DHH1

Genes: 34

SGD Description
Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, role in translational repression, mRNA decay, and processing body dynamics; may have a role in mRNA export; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress


PomBase Description
ATP-dependent RNA helicase Ste13


AspGD Description
Ortholog(s) have chromatin binding, mRNA binding, translation regulator activity, nucleic acid binding activity


References

Strahl-Bolsinger S, et al. (1993 Apr). A yeast gene encoding a putative RNA helicase of the "DEAD"-box family.

Maekawa H, et al. (1994 Sep 1). The ste13+ gene encoding a putative RNA helicase is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development in the fission yeast Schizosaccharomyces pombe.

Hata H, et al. (1998 Feb). Dhh1p, a putative RNA helicase, associates with the general transcription factors Pop2p and Ccr4p from Saccharomyces cerevisiae.

Coller JM, et al. (2001 Dec). The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes.

Maillet L, et al. (2002 Jan 25). Interaction between Not1p, a component of the Ccr4-not complex, a global regulator of transcription, and Dhh1p, a putative RNA helicase.

Fischer N, et al. (2002 Jun 3). The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1.

Sheth U, et al. (2003 May 2). Decapping and decay of messenger RNA occur in cytoplasmic processing bodies.

Tseng-Rogenski SS, et al. (2003 Sep 1). Functional conservation of Dhh1p, a cytoplasmic DExD/H-box protein present in large complexes.

Bergkessel M, et al. (2004 May). An essential role for the Saccharomyces cerevisiae DEAD-box helicase DHH1 in G1/S DNA-damage checkpoint recovery.

Teixeira D, et al. (2005 Apr). Processing bodies require RNA for assembly and contain nontranslating mRNAs.

Cheng Z, et al. (2005 Aug). Crystal structure and functional analysis of DEAD-box protein Dhh1p.

Muhlrad D, et al. (2005 Mar 9). The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p, and Not5p.

Lemieux C, et al. (2009 Jun). Cotranscriptional recruitment of the nuclear poly(A)-binding protein Pab2 to nascent transcripts and association with translating mRNPs.

Talarek N, et al. (2010 May 14). Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway.

Wang CY, et al. (2013 Mar). Pdc1 functions in the assembly of P bodies in Schizosaccharomyces pombe.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Hu G, et al. (2015 Jul). A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Wurm JP, et al. (2016 Sep). The S. pombe mRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02844
EOG8RV17C

sce:DBP5

Genes: 32

SGD Description
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus, remodeling messenger ribonucleoprotein particles (mRNPs), with ATPase activity stimulated by Gle1p, IP6 and Nup159p; involved in translation termination along with Sup45p (eRF1); role in the cellular response to heat stress


PomBase Description
cytoplasmic ATP-dependent RNA helicase Dbp5 (predicted)


AspGD Description
Ortholog(s) have cytosol, nuclear envelope localization


References

Chang TH, et al. (1990 Feb). Identification of five putative yeast RNA helicase genes.

Snay-Hodge CA, et al. (1998 May 1). Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export.

Tseng SS, et al. (1998 May 1). Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export.

Schmitt C, et al. (1999 Aug 2). Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p.

Hodge CA, et al. (1999 Oct 15). Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells.

Strahm Y, et al. (1999 Oct 15). The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p.

Hilleren P, et al. (2001 May). Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3'-end formation of nascent transcripts.

Hammell CM, et al. (2002 Sep). Coupling of termination, 3' processing, and mRNA export.

Estruch F, et al. (2003 Apr). An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH components.

Takemura R, et al. (2004 Aug 15). Stress response in yeast mRNA export factor: reversible changes in Rat8p localization are caused by ethanol stress but not heat shock.

Weirich CS, et al. (2004 Dec 3). The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear pore.

Yuasa T, et al. (2004 Nov). An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.

Estruch F, et al. (2005 Mar 11). Physical and genetic interactions link the yeast protein Zds1p with mRNA nuclear export.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Ren L, et al. (2011 Feb 28). Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%

FOG02845
EOG8RV17C

sce:FAL1

Genes: 32

SGD Description
Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases


PomBase Description
ATP-dependent RNA helicase (predicted)


AspGD Description
Ortholog(s) have cytosol, nucleus localization


References

Kressler D, et al. (1997 Dec). Fal1p is an essential DEAD-box protein involved in 40S-ribosomal-subunit biogenesis in Saccharomyces cerevisiae.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Savoldi M, et al. (2008 Oct). Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%