FOG02840
EOG86Q57K

sce:SKI2

Genes: 35

SGD Description
Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, SKIV2L, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome


PomBase Description
Ski complex RNA helicase Ski2 (predicted)|TRAMP complex ATP-dependent RNA helicase (predicted)


AspGD Description
Ortholog(s) have cytosol localization


References

Toh-E A, et al. (1978 Dec). Chromosomal superkiller mutants of Saccharomyces cerevisiae.

Ridley SP, et al. (1984 Apr). Superkiller mutations in Saccharomyces cerevisiae suppress exclusion of M2 double-stranded RNA by L-A-HN and confer cold sensitivity in the presence of M and L-A-HN.

Widner WR, et al. (1993 Jul). Evidence that the SKI antiviral system of Saccharomyces cerevisiae acts by blocking expression of viral mRNA.

Lygerou Z, et al. (1994 Dec 11). The yeast BDF1 gene encodes a transcription factor involved in the expression of a broad class of genes including snRNAs.

Johnson AW, et al. (1995 May). Synthetic lethality of sep1 (xrn1) ski2 and sep1 (xrn1) ski3 mutants of Saccharomyces cerevisiae is independent of killer virus and suggests a general role for these genes in translation control.

Masison DC, et al. (1995 May). Decoying the cap- mRNA degradation system by a double-stranded RNA virus and poly(A)- mRNA surveillance by a yeast antiviral system.

Anderson JS, et al. (1998 Mar 2). The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex.

Searfoss AM, et al. (2000 Aug 1). 3' poly(A) is dispensable for translation.

van Hoof A, et al. (2000 Jan). Yeast exosome mutants accumulate 3'-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs.

Brown JT, et al. (2000 Mar). The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivo.

Brown JT, et al. (2001 Nov). A cis-acting element known to block 3' mRNA degradation enhances expression of polyA-minus mRNA in wild-type yeast cells and phenocopies a ski mutant.

Araki Y, et al. (2001 Sep 3). Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast.

Kushner DB, et al. (2003 Dec 23). Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus.

Mitchell P, et al. (2003 May). An NMD pathway in yeast involving accelerated deadenylation and exosome-mediated 3'-->5' degradation.

Aloy P, et al. (2004 Mar 26). Structure-based assembly of protein complexes in yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02841
EOG86Q57K

sce:MTR4

Genes: 32

SGD Description
ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing


PomBase Description
ATP-dependent RNA helicase, TRAMP complex subunit Mtr4


AspGD Description
Ortholog(s) have role in regulation of circadian rhythm and TRAMP complex localization


References

Liang S, et al. (1996 Sep). A DEAD-box-family protein is required for nucleocytoplasmic transport of yeast mRNA.

de la Cruz J, et al. (1998 Feb 16). Dob1p (Mtr4p) is a putative ATP-dependent RNA helicase required for the 3' end formation of 5.8S rRNA in Saccharomyces cerevisiae.

Vanácová S, et al. (2005 Jun). A new yeast poly(A) polymerase complex involved in RNA quality control.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Savoldi M, et al. (2008 Oct). Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%