FOG02824
EOG89S4NW
EOG8TDZ1M

sce:PRC1;

Genes: 68

SGD Description
Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family|Putative serine type carboxypeptidase; role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner


PomBase Description
vacuolar carboxypeptidase Y


AspGD Description
Carboxypeptidase Y; expression repressed by tunicamycin and DTT


References

Hasilik A, et al. (1978 Apr 17). Biosynthesis of the vacuolar yeast glycoprotein carboxypeptidase Y. Conversion of precursor into the enzyme.

Valls LA, et al. (1987 Mar 13). Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide.

Bech LM, et al. (1989). Inactivation of carboxypeptidase Y by mutational removal of the putative essential histidyl residue.

Mortensen UH, et al. (1994 Jan 18). Site-directed mutagenesis on (serine) carboxypeptidase Y. A hydrogen bond network stabilizes the transition state by interaction with the C-terminal carboxylate group of the substrate.

Nasr F, et al. (1994 Jul). An analysis of the sequence of part of the right arm of chromosome II of S. cerevisiae reveals new genes encoding an amino-acid permease and a carboxypeptidase.

Endrizzi JA, et al. (1994 Sep 20). 2.8-A structure of yeast serine carboxypeptidase.

Stennicke HR, et al. (1996 Jun 4). Studies on the hydrolytic properties of (serine) carboxypeptidase Y.

Ohsumi K, et al. (2001 May). Cloning and characterization of the cpyA gene encoding intracellular carboxypeptidase from Aspergillus nidulans.

Ohneda M, et al. (2002 Oct). Visualization of vacuoles in Aspergillus oryzae by expression of CPY-EGFP.

Mima J, et al. (2005 Mar 11). Structure of the carboxypeptidase Y inhibitor IC in complex with the cognate proteinase reveals a novel mode of the proteinase-protein inhibitor interaction.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.

Matsumoto R, et al. (2013 Dec). Organelle acidification is important for localisation of vacuolar proteins in Saccharomyces cerevisiae.

Park DS, et al. (2015 Feb). Negative regulation of the vacuole-mediated resistance to K(+) stress by a novel C2H2 zinc finger transcription factor encoded by aslA in Aspergillus nidulans.

Yu X, et al. (2015 Jan). High-level expression and characterization of carboxypeptidase Y from Saccharomyces cerevisiae in Pichia pastoris GS115.

B S GK, et al. (2017 May). N-Glycosylation analysis of yeast Carboxypeptidase Y reveals the ultimate removal of phosphate from glycans at Asn₃₆₈.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02825
EOG89S4NW
EOG8TDZ1M

sce:absent

Genes: 3

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02826


sce:absent

Genes: 0

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02827
EOG89S4NW

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02828
EOG89S4NW
EOG8TDZ1M

sce:absent

Genes: 9

AspGD Description
Carboxypeptidase Y family secreted protease; expression repressed by tunicamycin and DTT|Has domain(s) with predicted serine-type carboxypeptidase activity and role in proteolysis|Ortholog(s) have extracellular region localization|Putative acid protease; carboxypeptidase|Putative protease|Ortholog(s) have extracellular region localization


References

Kim Y, et al. (2011 Nov). Autophagy induced by rapamycin and carbon-starvation have distinct proteome profiles in Aspergillus nidulans.

Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.

Szilágyi M, et al. (2013 Jan). Transcriptome changes initiated by carbon starvation in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02829


sce:absent

Genes: 0

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02830
EOG89S4NW

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%