FOG02764
EOG8J3V0K
EOG8QJQ66

sce:YPQ2

Genes: 41

SGD Description
Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN10166, A. fumigatus Af293 : Afu1g11900/gprG, A. oryzae RIB40 : AO090001000374/gprG and Aspergillus wentii : Aspwe1_0027952


References

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Jézégou A, et al. (2012 Dec 11). Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 41 genes with posterior transmembrane prediction > 50%

FOG02765
EOG8QJQ66

sce:absent

Genes: 25

PomBase Description
G-protein coupled receptor Stm1


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN5720/gprJ, A. fumigatus Af293 : Afu1g06840/gprJ, A. oryzae RIB40 : AO090001000486/gprJ, Aspergillus wentii : Aspwe1_0109188 and Aspergillus sydowii : Aspsy1_0149130


References

Chung KS, et al. (2001 Oct 26). Isolation of a novel gene from Schizosaccharomyces pombe: stm1+ encoding a seven-transmembrane loop protein that may couple with the heterotrimeric Galpha 2 protein, Gpa2.

Chung KS, et al. (2003 Feb). Functional over-expression of the Stm1 protein, a G-protein-coupled receptor, in Schizosaccharomyces pombe.

Yu JH, et al. (2006 Apr). Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans.

Lafon A, et al. (2006 Jul). G-protein and cAMP-mediated signaling in aspergilli: a genomic perspective.

Chung KS, et al. (2007 May 1). Yeast-based screening to identify modulators of G-protein signaling using uncontrolled cell division cycle by overexpression of Stm1.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Chung KS, et al. (2008 Aug). Identification of small molecules inducing apoptosis by cell-based assay using fission yeast deletion mutants.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 25 genes with posterior transmembrane prediction > 50%

FOG02766
EOG8QJQ66

sce:RTC2;YPQ1

Genes: 32

SGD Description
Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication|Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog, RTC2, that arose from the whole genome duplication


AspGD Description
Ortholog(s) have basic amino acid transmembrane transporter activity


References

Anderson JB, et al. (2003 Apr). Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae.

Markovich S, et al. (2004 Oct). Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae.

Reinders J, et al. (2006 Jul). Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Addinall SG, et al. (2008 Dec). A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae.

Jiménez-Martí E, et al. (2008 Mar). Addition of ammonia or amino acids to a nitrogen-depleted medium affects gene expression patterns in yeast cells during alcoholic fermentation.

Jézégou A, et al. (2012 Dec 11). Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 32 genes with posterior transmembrane prediction > 50%