FOG02763
EOG8G4F77

sce:YHC3

Genes: 33

SGD Description
Protein required for the ATP-dependent transport of arginine; vacuolar membrane protein; involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; human homolog CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) can complement yeast null mutant


PomBase Description
battenin CLN3 family protein


AspGD Description
Ortholog(s) have role in actin cortical patch localization, arginine transport, cellular protein localization, endocytosis, late endosome to vacuole transport and lysine transport, more


References

Pearce DA, et al. (1997 Jun 30). BTN1, a yeast gene corresponding to the human gene responsible for Batten's disease, is not essential for viability, mitochondrial function, or degradation of mitochondrial ATP synthase.

Croopnick JB, et al. (1998 Sep 18). The subcellular location of the yeast Saccharomyces cerevisiae homologue of the protein defective in the juvenile form of Batten disease.

Pearce DA, et al. (1999 May). Action of BTN1, the yeast orthologue of the gene mutated in Batten disease.

Chattopadhyay S, et al. (2000 Nov). The yeast model for batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis.

Kim Y, et al. (2003 Dec 23). A role in vacuolar arginine transport for yeast Btn1p and for human CLN3, the protein defective in Batten disease.

Gachet Y, et al. (2005 Dec 1). btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis.

Kim Y, et al. (2005 Feb). Interaction among Btn1p, Btn2p, and Ist2p reveals potential interplay among the vacuole, amino acid levels, and ion homeostasis in the yeast Saccharomyces cerevisiae.

Codlin S, et al. (2008 Jun). btn1 affects endocytosis, polarization of sterol-rich membrane domains and polarized growth in Schizosaccharomyces pombe.

Pears MR, et al. (2010 Jun). Deletion of btn1, an orthologue of CLN3, increases glycolysis and perturbs amino acid metabolism in the fission yeast model of Batten disease.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%