FOG02698
EOG89P8G7
EOG8HT778

sce:PNS1

Genes: 33

SGD Description
Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport


AspGD Description
Has domain(s) with predicted intracellular localization


References

Zufferey R, et al. (2004 Feb). Reexamining the role of choline transporter-like (Ctlp) proteins in choline transport.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%

FOG02699
EOG8HT778

sce:MDR1

Genes: 33

SGD Description
Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function


PomBase Description
GTPase activating protein (predicted)


AspGD Description
Ortholog(s) have GTPase activator activity, role in intracellular protein transport and cell division site, cytosol localization


References

Albert S, et al. (1999 Nov 19). Two new members of a family of Ypt/Rab GTPase activating proteins. Promiscuity of substrate recognition.

Lafourcade C, et al. (2003 Jun). Opposite roles of the F-box protein Rcy1p and the GTPase-activating protein Gyp2p during recycling of internalized proteins in yeast.

Sciorra VA, et al. (2005 Feb). Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%

FOG02700
EOG8HT778

sce:GYP5

Genes: 32

SGD Description
GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication


PomBase Description
GTPase activating protein Gyp51 (predicted)


AspGD Description
Ortholog(s) have role in ER to Golgi vesicle-mediated transport, regulation of exocytosis


References

Bi E, et al. (2000 Feb). Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast.

De Antoni A, et al. (2002 Oct 25). Significance of GTP hydrolysis in Ypt1p-regulated endoplasmic reticulum to Golgi transport revealed by the analysis of two novel Ypt1-GAPs.

Chesneau L, et al. (2004 Sep 15). Gyp5p and Gyl1p are involved in the control of polarized exocytosis in budding yeast.

Friesen H, et al. (2005 Jun). Interaction of the Saccharomyces cerevisiae cortical actin patch protein Rvs167p with proteins involved in ER to Golgi vesicle trafficking.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 12 genes with posterior transmembrane prediction > 50%

FOG02701
EOG8HT778

sce:MSB3;MSB4

Genes: 31

SGD Description
Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; required for proper actin organization; also localizes to plasma membrane and sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to the TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication|GTPase-activating protein of the Ras superfamily; acts primarily on Sec4p, localizes to the bud site and bud tip; msb3 msb4 double mutation causes defects in secretion and actin organization; similar to the TBC-domain Tre2 oncogene; MSB4 has a paralog, MSB3, that arose from the whole genome duplication


PomBase Description
GTPase activating protein Gyp3 (predicted)


References

Bi E, et al. (2000 Feb). Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast.

Gao XD, et al. (2003 Aug 18). The GAP activity of Msb3p and Msb4p for the Rab GTPase Sec4p is required for efficient exocytosis and actin organization.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 26 genes with posterior transmembrane prediction > 50%

FOG02702
EOG86HDWV
EOG883BKV
EOG8HT778

sce:absent

Genes: 18

PomBase Description
GTPase activating protein (predicted)


AspGD Description
Has domain(s) with predicted intracellular localization


References

Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%

FOG02703
EOG8HT778

sce:absent

Genes: 8

AspGD Description
Has domain(s) with predicted intracellular localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 5 genes with posterior transmembrane prediction > 50%

FOG02704
EOG89P8G7

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02705
EOG8HT778

sce:GYL1

Genes: 3

SGD Description
Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress; GYL1 has a paralog, GYP5, that arose from the whole genome duplication


PomBase Description
GTPase activating protein Gyp2 (predicted)


References

Chesneau L, et al. (2004 Sep 15). Gyp5p and Gyl1p are involved in the control of polarized exocytosis in budding yeast.

Friesen H, et al. (2005 Jun). Interaction of the Saccharomyces cerevisiae cortical actin patch protein Rvs167p with proteins involved in ER to Golgi vesicle trafficking.

Denison C, et al. (2005 Mar). A proteomic strategy for gaining insights into protein sumoylation in yeast.

Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%