FOG02430
EOG80CFXT
EOG83TXCG
EOG8QJQ31
sce:STE6
Genes: 82
EOG80CFXT
EOG83TXCG
EOG8QJQ31
sce:STE6
Genes: 82
SGD Description
Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; human homolog ABCB1 mediates multidrug resistance in many chemotherapy-resistant tumors by effluxing toxic compounds from the cell
PomBase Description
M-factor transmembrane transporter Mam1|leptomycin transmembrane transporter Pmd1
AspGD Description
Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transmembrane transport|Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transmembrane transport|Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transmembrane transport|Ortholog(s) have ATPase activity, coupled to transmembrane movement of substances activity, role in cellular response to drug, drug transmembrane transport and plasma membrane, vacuole localization|Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transmembrane transport|Similar to multidrug resistance protein; expression induced by tunicamycin and DTT|Ortholog(s) have oligopeptide-transporting ATPase activity
References
Wilson KL, et al. (1986 Apr). Sequences upstream of the STE6 gene required for its expression and regulation by the mating type locus in Saccharomyces cerevisiae.
McGrath JP, et al. (1989 Aug 3). The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein.
Kuchler K, et al. (1989 Dec 20). Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells.
Berkower C, et al. (1991 Dec). Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily.
Nishi K, et al. (1992 Mar). A leptomycin B resistance gene of Schizosaccharomyces pombe encodes a protein similar to the mammalian P-glycoproteins.
Nishi K, et al. (1993). Mating of the fission yeast occurs independently of pmd1+ gene product, a structural homologue of budding yeast STE6 and mammalian P-glycoproteins.
Kölling R, et al. (1994 Jul 15). The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants.
Nishi K, et al. (1994 Mar 4). Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.
Geller D, et al. (1996 Jun 7). Comparative topology studies in Saccharomyces cerevisiae and in Escherichia coli. The N-terminal half of the yeast ABC protein Ste6.
Christensen PU, et al. (1997 Feb 1). Abc1: a new ABC transporter from the fission yeast Schizosaccharomyces pombe.
Raymond M, et al. (1998 Feb). A Ste6p/P-glycoprotein homologue from the asexual yeast Candida albicans transports the a-factor mating pheromone in Saccharomyces cerevisiae.
Toone WM, et al. (1998 May 15). Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1.
Andrade AC, et al. (2000 Jul). The role of ABC transporters from Aspergillus nidulans in protection against cytotoxic agents and in antibiotic production.
Del Sorbo G, et al. (2000 Jun). Fungal transporters involved in efflux of natural toxic compounds and fungicides.
do Nascimento AM, et al. (2002 Dec 31). Molecular characterization of ABC transporter-encoding genes in Aspergillus nidulans.
Semighini CP, et al. (2002 Mar). Quantitative analysis of the relative transcript levels of ABC transporter Atr genes in Aspergillus nidulans by real-time reverse transcription-PCR assay.
Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.
Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.
Semighini CP, et al. (2004 Oct). Multi-copy suppression of an Aspergillus nidulans mutant sensitive to camptothecin by a putative monocarboxylate transporter.
Iwaki T, et al. (2006 Aug). A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
de Waard MA, et al. (2006 Mar). Impact of fungal drug transporters on fungicide sensitivity, multidrug resistance and virulence.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
Akiyama K, et al. (2011 Jan). Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe.
Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Kashiwazaki J, et al. (2011 Oct). Endocytosis is essential for dynamic translocation of a syntaxin 1 orthologue during fission yeast meiosis.
Kawashima SA, et al. (2012 Jul 27). Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.
Tay Z, et al. (2013). Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast.
Tay Z, et al. (2014). P-glycoprotein and vacuolar ATPase synergistically confer anthracycline resistance to fission yeast and human cells.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Nguyen TT, et al. (2015 Feb 11). Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.
Nguyen TT, et al. (2016 Jan 21). Predicting chemotherapeutic drug combinations through gene network profiling.
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| Phobius transmembrane predictions
82 genes with posterior transmembrane prediction > 50% |
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FOG02431
EOG83TXCG
sce:absent
Genes: 2
EOG83TXCG
sce:absent
Genes: 2
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2 genes with posterior transmembrane prediction > 50% |
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FOG02432
EOG83TXCG
sce:absent
Genes: 7
EOG83TXCG
sce:absent
Genes: 7
PomBase Description
vacuolar transmembrane transporter Hmt1
AspGD Description
Ortholog(s) have glutathione transmembrane transporter activity, phytochelatin transmembrane transporter ATPase activity
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7 genes with posterior transmembrane prediction > 50% |
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FOG02433
EOG83TXCG
sce:MDL1;MDL2
Genes: 58
EOG83TXCG
sce:MDL1;MDL2
Genes: 58
SGD Description
Mitochondrial inner membrane half-type ABC transporter; mediates export of peptides generated upon proteolysis of mitochondrial proteins; plays a role in the regulation of cellular resistance to oxidative stress|Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
PomBase Description
mitochondrial peptide-transporting ATPase
AspGD Description
Ortholog(s) have oligopeptide-transporting ATPase activity, role in oligopeptide export from mitochondrion and mitochondrial inner membrane localization
References
Dean M, et al. (1994 Mar). Mapping and sequencing of two yeast genes belonging to the ATP-binding cassette superfamily.
Young L, et al. (2001 Mar 16). Role of the ABC transporter Mdl1 in peptide export from mitochondria.
Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.
Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
58 genes with posterior transmembrane prediction > 50% |
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FOG02434
EOG83TXCG
sce:ATM1
Genes: 35
EOG83TXCG
sce:ATM1
Genes: 35
SGD Description
Mitochondrial inner membrane ATP-binding cassette (ABC) transporter; exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; human homolog ABCB7 complements yeast null mutant
PomBase Description
mitochondrial ABC family iron transmembrane transporter Atm1
AspGD Description
Ortholog(s) have ATPase activity, coupled to transmembrane movement of substances activity, role in cellular iron ion homeostasis, cellular response to oxidative stress, transmembrane transport and mitochondrial inner membrane localization
References
Leighton J, et al. (1995 Jan 3). An ABC transporter in the mitochondrial inner membrane is required for normal growth of yeast.
Kispal G, et al. (1997 Dec 1). The ABC transporter Atm1p is required for mitochondrial iron homeostasis.
Kispal G, et al. (1999 Jul 15). The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins.
Chloupková M, et al. (2004 Jul 2). The mitochondrial ABC transporter Atm1p functions as a homodimer.
Galagan JE, et al. (2005 Dec 22). Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.
Iwaki T, et al. (2005 Nov). Mitochondrial ABC transporter Atm1p is required for protection against oxidative stress and vacuolar functions in Schizosaccharomyces pombe.
Iwaki T, et al. (2006 Aug). A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
Akiyama K, et al. (2011 Jan). Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe.
Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Kawashima SA, et al. (2012 Jul 27). Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Srinivasan V, et al. (2014 Mar 7). Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1.
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| Phobius transmembrane predictions
34 genes with posterior transmembrane prediction > 50% |
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