FOG02313
EOG8B5MMN

sce:PUS7

Genes: 33

SGD Description
Pseudouridine synthase; catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); also pseudouridylates some mRNAs; relocates from nucleus to cytoplasm during heat shock and differentially modifies some mRNAs during heat shock; conserved in archaea, vertebrates, and some bacteria


PomBase Description
pseudouridine synthase Pus7 (predicted)


AspGD Description
Ortholog(s) have pseudouridine synthase activity, role in enzyme-directed rRNA pseudouridine synthesis, mRNA pseudouridine synthesis, snRNA pseudouridine synthesis, tRNA pseudouridine synthesis and cytoplasm, nucleus localization


References

Newby MI, et al. (2002 Dec). Sculpting of the spliceosomal branch site recognition motif by a conserved pseudouridine.

Ma X, et al. (2003 Apr 15). Pseudouridylation (Psi) of U2 snRNA in S. cerevisiae is catalyzed by an RNA-independent mechanism.

Behm-Ansmant I, et al. (2003 Nov). The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Psi-synthase also acting on tRNAs.

Yang C, et al. (2005 Feb 25). Psi35 in the branch site recognition region of U2 small nuclear RNA is important for pre-mRNA splicing in Saccharomyces cerevisiae.

Decatur WA, et al. (2008 May). Different mechanisms for pseudouridine formation in yeast 5S and 5.8S rRNAs.

Lin Y, et al. (2008 May 20). X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.

Urban A, et al. (2009 Feb 27). RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:{Psi}-synthase Pus7p.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%