FOG02297
EOG8PG4KN

sce:SES1

Genes: 34

SGD Description
Cytosolic seryl-tRNA synthetase; class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p


PomBase Description
cytoplasmic serine-tRNA ligase Srs1 (predicted)


AspGD Description
Ortholog(s) have cytosol localization


References

Weygand-Durasevic I, et al. (1987 Mar 11). Cloning and characterization of the gene coding for cytoplasmic seryl-tRNA synthetase from Saccharomyces cerevisiae.

Folley LS, et al. (1994 Jun). Reduced dosage of genes encoding ribosomal protein S18 suppresses a mitochondrial initiation codon mutation in Saccharomyces cerevisiae.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Ren L, et al. (2011 Feb 28). Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Halim A, et al. (2015 Dec 22). Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02298
EOG8PG4KN

sce:DIA4

Genes: 33

SGD Description
Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth


PomBase Description
mitochondrial serine-tRNA ligase (predicted)


AspGD Description
Ortholog(s) have serine-tRNA ligase activity, role in invasive growth in response to glucose limitation, mitochondrial seryl-tRNA aminoacylation, pseudohyphal growth, spore germination and mitochondrion localization


References

Osherov N, et al. (2000 Jun). Conidial germination in Aspergillus nidulans requires RAS signaling and protein synthesis.

Coutinho PM, et al. (2009 Mar). Post-genomic insights into the plant polysaccharide degradation potential of Aspergillus nidulans and comparison to Aspergillus niger and Aspergillus oryzae.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02299
EOG83TXDK
EOG8PG4KN

sce:RHB1

Genes: 30

SGD Description
Putative Rheb-related GTPase; involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins


PomBase Description
Rheb GTPase Rhb1


AspGD Description
Putative GTP-binding protein; induced by caspofungin


References

Pure GA, et al. (1985 May 5). Partial suppression of an ochre mutation in Saccharomyces cerevisiae by multicopy plasmids containing a normal yeast tRNAGln gene.

Urano J, et al. (2000 Apr 14). The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake.

Yang W, et al. (2000 Jan 7). Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe.

Mach KE, et al. (2000 Jun). Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation.

Chattopadhyay S, et al. (2002 Aug). Interaction with Btn2p is required for localization of Rsglp: Btn2p-mediated changes in arginine uptake in Saccharomyces cerevisiae.

Tabancay AP Jr, et al. (2003 Oct 10). Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K.

van Slegtenhorst M, et al. (2004 Mar 26). Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe.

Urano J, et al. (2005 Nov). Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast.

van Slegtenhorst M, et al. (2005 Oct 1). Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe.

Uritani M, et al. (2006 Dec). Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase.

Nakase Y, et al. (2006 Jun). A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.

Matsuo T, et al. (2007 Apr). Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.

van Slegtenhorst M, et al. (2007 Aug 24). The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.

Urano J, et al. (2007 Feb 27). Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells.

Harispe L, et al. (2008 Jan). Ras GTPase-activating protein regulation of actin cytoskeleton and hyphal polarity in Aspergillus nidulans.

Aspuria PJ, et al. (2008 May). The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast.

Murai T, et al. (2009 Oct). Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.

Nakashima A, et al. (2010). Conservation of the Tsc/Rheb/TORC1/S6K/S6 Signaling in Fission Yeast.

Nakashima A, et al. (2010 Mar 1). Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Banerjee S, et al. (2013 Aug). Splicing functions and global dependency on fission yeast slu7 reveal diversity in spliceosome assembly.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Laor D, et al. (2014 Mar). Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Davie E, et al. (2015 Feb 16). Nitrogen regulates AMPK to control TORC1 signaling.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%