FOG02281
EOG8R7SRS

sce:GUS1

Genes: 34

SGD Description
Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress


PomBase Description
cytoplasmic glutamate-tRNA ligase gus1 (predicted)


AspGD Description
Ortholog(s) have cytosol, nucleus localization


References

Simos G, et al. (1996 Oct 1). The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases.

Simos G, et al. (1998 Jan). A conserved domain within Arc1p delivers tRNA to aminoacyl-tRNA synthetases.

Galani K, et al. (2001 Dec 3). The intracellular location of two aminoacyl-tRNA synthetases depends on complex formation with Arc1p.

Deinert K, et al. (2001 Feb 23). Arc1p organizes the yeast aminoacyl-tRNA synthetase complex and stabilizes its interaction with the cognate tRNAs.

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Simader H, et al. (2006). Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes.

Simader H, et al. (2006 Dec). Structures of the interacting domains from yeast glutamyl-tRNA synthetase and tRNA-aminoacylation and nuclear-export cofactor Arc1p reveal a novel function for an old fold.

Paul SK, et al. (2009 Jun). Glutamyl tRNA synthetases and glutamic acid induce sexual differentiation of Schizosaccharomyces pombe.

Frechin M, et al. (2009 May 1). Yeast mitochondrial Gln-tRNA(Gln) is generated by a GatFAB-mediated transamidation pathway involving Arc1p-controlled subcellular sorting of cytosolic GluRS.

Anderson HE, et al. (2010 Oct 18). Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Gerke J, et al. (2012 Jun). Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulans.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mathiassen SG, et al. (2015 Aug 21). A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02282
EOG815DVM
EOG8R7SRS

sce:CYK3

Genes: 33

Parent
paralog:FOG02281


SGD Description
SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants


PomBase Description
cytokinesis protein Cyk3 (predicted)


AspGD Description
Ortholog(s) have cell division site, cell tip localization


References

Korinek WS, et al. (2000 Jul 27-Aug 10). Cyk3, a novel SH3-domain protein, affects cytokinesis in yeast.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Dixon SJ, et al. (2008 Oct 28). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Nishihama R, et al. (2009 Jun 15). Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae.

Jendretzki A, et al. (2009 Oct). Cyk3 acts in actomyosin ring independent cytokinesis by recruiting Inn1 to the yeast bud neck.

Roberts-Galbraith RH, et al. (2010 Jul 9). Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.

Bohnert KA, et al. (2012). Cytokinesis-based constraints on polarized cell growth in fission yeast.

Pollard LW, et al. (2012 Jul). Fission yeast Cyk3p is a transglutaminase-like protein that participates in cytokinesis and cell morphogenesis.

Chen JS, et al. (2013 May). Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lipp JJ, et al. (2015 Aug). SR protein kinases promote splicing of nonconsensus introns.

Ren L, et al. (2015 Jan 15). The Cdc15 and Imp2 SH3 domains cooperatively scaffold a network of proteins that redundantly ensure efficient cell division in fission yeast.

Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.

McDonald NA, et al. (2017 Sep 15). Nanoscale architecture of the <i>Schizosaccharomyces pombe</i> contractile ring.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%