FOG02173
EOG8HHMJ1

sce:LCB4;LCB5

Genes: 36

SGD Description
Sphingoid long-chain base kinase; responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes; LCB4 has a paralog, LCB5, that arose from the whole genome duplication|Minor sphingoid long-chain base kinase; possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules; LCB5 has a paralog, LCB4, that arose from the whole genome duplication


PomBase Description
sphingoid long chain base kinase (predicted)


AspGD Description
Ortholog(s) have D-erythro-sphingosine kinase activity, role in calcium-mediated signaling, response to heat, sphingolipid metabolic process and Golgi apparatus, membrane localization


References

Nagiec MM, et al. (1998 Jul 31). The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases.

Kim S, et al. (2000 Dec). Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae.

Birchwood CJ, et al. (2001 Apr 13). Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation.

Zhang X, et al. (2001 Dec). Elevation of endogenous sphingolipid long-chain base phosphates kills Saccharomyces cerevisiae cells.

Jenkins GM, et al. (2001 Mar 16). Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.

Hait NC, et al. (2002 Dec 4). Lcb4p sphingoid base kinase localizes to the Golgi and late endosomes.

Ferguson-Yankey SR, et al. (2002 May). Mutant analysis reveals complex regulation of sphingolipid long chain base phosphates and long chain bases during heat stress in yeast.

Funato K, et al. (2003 Feb 28). Lcb4p is a key regulator of ceramide synthesis from exogenous long chain sphingoid base in Saccharomyces cerevisiae.

Iwaki S, et al. (2005 Feb 25). Phosphorylation by Pho85 cyclin-dependent kinase acts as a signal for the down-regulation of the yeast sphingoid long-chain base kinase Lcb4 during the stationary phase.

Kihara A, et al. (2005 Nov). Long-chain base kinase Lcb4 Is anchored to the membrane through its palmitoylation by Akr1.

Sano T, et al. (2005 Nov 4). Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: studies in phytosphingosine-resistant mutants.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%