FOG02170
EOG8PVMFQ
sce:LCB2
Genes: 36
EOG8PVMFQ
sce:LCB2
Genes: 36
SGD Description
Component of serine palmitoyltransferase; responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
PomBase Description
serine palmitoyltransferase Lcb2 (predicted)
AspGD Description
Serine palmitoyltransferase|Serine palmitoyltransferase
References
Nagiec MM, et al. (1994 Aug 16). The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis.
Zhao C, et al. (1994 Aug 26). Suppressors of the Ca(2+)-sensitive yeast mutant (csg2) identify genes involved in sphingolipid biosynthesis. Cloning and characterization of SCS1, a gene required for serine palmitoyltransferase activity.
Nagiec MM, et al. (1996 Oct 24). Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase.
Gable K, et al. (2000 Mar 17). Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity.
Gable K, et al. (2002 Mar 22). Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase.
Han G, et al. (2004 Dec 17). The topology of the Lcb1p subunit of yeast serine palmitoyltransferase.
Breslow DK, et al. (2010 Feb 25). Orm family proteins mediate sphingolipid homeostasis.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
36 genes with posterior transmembrane prediction > 50% |
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FOG02171
EOG8PVMFQ
sce:LCB1
Genes: 32
EOG8PVMFQ
sce:LCB1
Genes: 32
SGD Description
Component of serine palmitoyltransferase; responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
PomBase Description
serine palmitoyltransferase complex subunit (predicted)
AspGD Description
Ortholog(s) have serine C-palmitoyltransferase activity, role in establishment of cell polarity, sphingolipid biosynthetic process and endoplasmic reticulum localization
References
Buede R, et al. (1991 Jul). Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids.
Nagiec MM, et al. (1994 Aug 16). The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis.
Gable K, et al. (2000 Mar 17). Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity.
Cheng J, et al. (2001 Sep). Cell cycle progression and cell polarity require sphingolipid biosynthesis in Aspergillus nidulans.
Gable K, et al. (2002 Mar 22). Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase.
Han G, et al. (2004 Dec 17). The topology of the Lcb1p subunit of yeast serine palmitoyltransferase.
Breslow DK, et al. (2010 Feb 25). Orm family proteins mediate sphingolipid homeostasis.
Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
32 genes with posterior transmembrane prediction > 50% |
||
