FOG02146
EOG89GHZ2
EOG8KPRS6

sce:INP52;INP53

Genes: 26

SGD Description
Polyphosphatidylinositol phosphatase; dephosphorylates a number of phosphatidylinositol phosphates (PtdInsPs, PIPs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain; INP52 has a paralog, INP53, that arose from the whole genome duplication|Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication


References

Luo Wj, et al. (1997 Aug 25). Novel genes involved in endosomal traffic in yeast revealed by suppression of a targeting-defective plasma membrane ATPase mutant.

Stolz LE, et al. (1998 Apr). Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae.

Singer-Krüger B, et al. (1998 Nov). Synaptojanin family members are implicated in endocytic membrane traffic in yeast.

Saiz JE, et al. (1999 Jan 30). Disruption of six unknown open reading frames from Saccharomyces cerevisiae reveals two genes involved in vacuolar morphogenesis and one gene required for sporulation.

Guo S, et al. (1999 May 7). SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases.

Ooms LM, et al. (2000 Dec). The yeast inositol polyphosphate 5-phosphatases inp52p and inp53p translocate to actin patches following hyperosmotic stress: mechanism for regulating phosphatidylinositol 4,5-bisphosphate at plasma membrane invaginations.

Bensen ES, et al. (2000 Jan). Synthetic genetic interactions with temperature-sensitive clathrin in Saccharomyces cerevisiae. Roles for synaptojanin-like Inp53p and dynamin-related Vps1p in clathrin-dependent protein sorting at the trans-Golgi network.

Hughes WE, et al. (2000 Jan 14). SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases.

Whisstock JC, et al. (2000 Nov 24). The inositol polyphosphate 5-phosphatases and the apurinic/apyrimidinic base excision repair endonucleases share a common mechanism for catalysis.

O'Malley CJ, et al. (2001 May 1). Mammalian inositol polyphosphate 5-phosphatase II can compensate for the absence of all three yeast Sac1-like-domain-containing 5-phosphatases.

Ha SA, et al. (2001 Oct). A novel mechanism for localizing membrane proteins to yeast trans-Golgi network requires function of synaptojanin-like protein.

Ha SA, et al. (2003 Apr). The synaptojanin-like protein Inp53/Sjl3 functions with clathrin in a yeast TGN-to-endosome pathway distinct from the GGA protein-dependent pathway.

Wicky S, et al. (2003 Feb 27). Bsp1p/Ypr171p is an adapter that directly links some synaptojanin family members to the cortical actin cytoskeleton in yeast.

Parrish WR, et al. (2004 Aug). Essential role for the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p in regulation of phosphatidylinositol 3-phosphate in yeast.

Stefan CJ, et al. (2005 Apr). The phosphoinositide phosphatase Sjl2 is recruited to cortical actin patches in the control of vesicle formation and fission during endocytosis.

Nguyen PH, et al. (2005 Feb). Interaction of Pik1p and Sjl proteins in membrane trafficking.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Böttcher C, et al. (2006 Jan 23). Sjl2p is specifically involved in early steps of endocytosis intimately linked to actin dynamics via the Ark1p/Prk1p kinases.

Sun Y, et al. (2007 Apr 23). PtdIns(4,5)P2 turnover is required for multiple stages during clathrin- and actin-dependent endocytic internalization.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%

FOG02147
EOG8KPRS6

sce:FIG4

Genes: 33

SGD Description
Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; homologous to human FIG4, which is associated with CMT4J, a form of Charcot-Marie-Tooth disorder


PomBase Description
inositol polyphosphate phosphatase (predicted)


AspGD Description
Ortholog(s) have phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity, role in phosphatidylinositol dephosphorylation and PAS complex, cytosol, fungal-type vacuole membrane, nuclear periphery localization


References

Gary JD, et al. (2002 Apr). Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.

Rudge SA, et al. (2004 Jan). Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase.

Duex JE, et al. (2006 Feb 27). The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover.

Chow CY, et al. (2007 Jul 5). Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J.

Jin N, et al. (2008 Dec 17). VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.

Botelho RJ, et al. (2008 Oct). Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Azzedine H, et al. (2012 Nov). Molecular genetics of charcot-marie-tooth disease: from genes to genomes.

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02148
EOG8KPRS6

sce:INP51

Genes: 33

SGD Description
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth


PomBase Description
inositol-polyphosphate 5-phosphatase (synaptojanin homolog 1)


AspGD Description
Ortholog(s) have calcium ion binding, inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity and inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity, more


References

Guiard B, et al. (1976). Complete amino acid sequence of the heme-binding core in bakers' yeast cytochrome b2 (L-(+)-lactate dehydrogenase).

Luo Wj, et al. (1997 Aug 25). Novel genes involved in endosomal traffic in yeast revealed by suppression of a targeting-defective plasma membrane ATPase mutant.

Stolz LE, et al. (1998 Apr). Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae.

Singer-Krüger B, et al. (1998 Nov). Synaptojanin family members are implicated in endocytic membrane traffic in yeast.

O'Malley CJ, et al. (2001 May 1). Mammalian inositol polyphosphate 5-phosphatase II can compensate for the absence of all three yeast Sac1-like-domain-containing 5-phosphatases.

Morales-Johansson H, et al. (2004 Sep 17). Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4.

Fadri M, et al. (2005 Apr). The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.

Nguyen PH, et al. (2005 Feb). Interaction of Pik1p and Sjl proteins in membrane trafficking.

Sun Y, et al. (2007 Apr 23). PtdIns(4,5)P2 turnover is required for multiple stages during clathrin- and actin-dependent endocytic internalization.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 16 genes with posterior transmembrane prediction > 50%

FOG02149
EOG8KPRS6

sce:SAC1

Genes: 35

SGD Description
Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism


PomBase Description
inositol polyphosphate phosphatase (predicted)


AspGD Description
Ortholog(s) have phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity, phosphatidylinositol-3-phosphatase activity, phosphatidylinositol-4-phosphate phosphatase activity


References

Cleves AE, et al. (1989 Dec). Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function.

Hughes WE, et al. (2000 Jan 14). SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases.

Foti M, et al. (2001 Aug). Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Breslow DK, et al. (2010 Feb 25). Orm family proteins mediate sphingolipid homeostasis.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 34 genes with posterior transmembrane prediction > 50%

FOG02150
EOG8KPRS6

sce:absent

Genes: 10

AspGD Description
Has domain(s) with predicted phosphoric ester hydrolase activity


References

Herrero S, et al. (2011 May). The Aspergillus nidulans CENP-E kinesin motor KipA interacts with the fungal homologue of the centromere-associated protein CENP-H at the kinetochore.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02151
EOG8KPRS6

sce:absent

Genes: 2

PomBase Description
inositol polyphosphate phosphatase (predicted)|inositol-polyphosphate 5-phosphatase, synaptojanin homolog 2 (predicted)

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%