FOG02140
EOG8C8689

sce:absent

Genes: 4

AspGD Description
Has domain(s) with predicted ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding activity

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02141
EOG8C8689

sce:absent

Genes: 2

PomBase Description
ATPase, involved in cytoplasmic translational initiation (predicted)


References

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Zhou X, et al. (2013). A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lucena R, et al. (2015 May 11). Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02142
EOG8C8689

sce:GCN20

Genes: 33

SGD Description
Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA


PomBase Description
AAA family ATPase Gcn20 (predicted)


AspGD Description
Ortholog(s) have cytosol localization


References

Vazquez de Aldana CR, et al. (1995 Jul 3). GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells.

Marton MJ, et al. (1997 Aug). Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2.

Garcia-Barrio M, et al. (2000 Apr 17). Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation.

Sattlegger E, et al. (2000 Dec 1). Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells.

Sattlegger E, et al. (2005 Apr 22). Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02143
EOG8C8689

sce:ARB1

Genes: 32

SGD Description
ATPase of the ATP-binding cassette (ABC) family; involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p


PomBase Description
ribosome biogenesis ATPase, Arb family ABCF2-like (predicted)


AspGD Description
Putative ABC transporter


References

Dong J, et al. (2005 Nov). The novel ATP-binding cassette protein ARB1 is a shuttling factor that stimulates 40S and 60S ribosome biogenesis.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02144
EOG8C8689

sce:NEW1

Genes: 34

SGD Description
ATP binding cassette protein; cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction


PomBase Description
AAA family ATPase Elf1


AspGD Description
Ortholog(s) have ATP binding, ATPase activity, mRNA binding activity and role in poly(A)+ mRNA export from nucleus, ribosomal small subunit biogenesis


References

Decottignies A, et al. (1997 Feb). Complete inventory of the yeast ABC proteins.

Santoso A, et al. (2000 Jan 21). Molecular basis of a yeast prion species barrier.

Derkatch IL, et al. (2001 Jul 27). Prions affect the appearance of other prions: the story of [PIN(+)].

Osherovich LZ, et al. (2001 Jul 27). Multiple Gln/Asn-rich prion domains confer susceptibility to induction of the yeast [PSI(+)] prion.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%

FOG02145
EOG8C8689

sce:YEF3;HEF3

Genes: 35

SGD Description
Translation elongation factor 3; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication|Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication


PomBase Description
translation elongation factor eEF3


AspGD Description
Protein similar to translation elongation factor 3


References

Dasmahapatra B, et al. (1981 Oct 10). Protein synthesis in yeast. I. Purification and properties of elongation factor 3 from Saccharomyces cerevisiae.

Sandbaken M, et al. (1990 Aug 27). Isolation and characterization of the structural gene encoding elongation factor 3.

Qin SL, et al. (1990 Feb 5). Sequence analysis of the translational elongation factor 3 from Saccharomyces cerevisiae.

Sandbaken MG, et al. (1990 Sep 15). Protein synthesis in yeast. Structural and functional analysis of the gene encoding elongation factor 3.

Colthurst DR, et al. (1992 Apr). Elongation factor 3 (EF-3) from Candida albicans shows both structural and functional similarity to EF-3 from Saccharomyces cerevisiae.

Myers KK, et al. (1992 Apr 11). Isolation and sequence analysis of the gene for translation elongation factor 3 from Candida albicans.

Di Domenico BJ, et al. (1992 May). Isolation and sequence analysis of the gene encoding translation elongation factor 3 from Candida albicans.

Kovalchuke O, et al. (1994 Nov 15). Comparative analysis of ribosome-associated adenosinetriphosphatase (ATPase) from pig liver and the ATPase of elongation factor 3 from Saccharomyces cerevisiae.

Triana-Alonso FJ, et al. (1995 Sep 1). The elongation factor 3 unique in higher fungi and essential for protein biosynthesis is an E site factor.

Garrels JI, et al. (1997 Aug). Proteome studies of Saccharomyces cerevisiae: identification and characterization of abundant proteins.

Gontarek RR, et al. (1998 Apr 24). The N terminus of eukaryotic translation elongation factor 3 interacts with 18 S rRNA and 80 S ribosomes.

Kovalchuke O, et al. (1998 Dec 15). Competition and cooperation amongst yeast elongation factors.

Sarthy AV, et al. (1998 Feb). Identification and kinetic analysis of a functional homolog of elongation factor 3, YEF3 in Saccharomyces cerevisiae.

Nakayama H, et al. (1998 Sep). A controllable gene-expression system for the pathogenic fungus Candida glabrata.

Maurice TC, et al. (1998 Sep 15). A highly conserved intraspecies homolog of the Saccharomyces cerevisiae elongation factor-3 encoded by the HEF3 gene.

Uritani M, et al. (1999 Apr). Detection and analysis of translation elongation factor 3 genes from various yeasts.

Futcher B, et al. (1999 Nov). A sampling of the yeast proteome.

Taricani L, et al. (2001 Jul 15). Expression of hsp16 in response to nucleotide depletion is regulated via the spc1 MAPK pathway in Schizosaccharomyces pombe.

Anand M, et al. (2003 Feb 28). Functional interactions between yeast translation eukaryotic elongation factor (eEF) 1A and eEF3.

Pitarch A, et al. (2004 Oct). Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.

Asp E, et al. (2008 Feb). Fission yeast mitogen-activated protein kinase Sty1 interacts with translation factors.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Anderson HE, et al. (2010 Oct 18). Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Couttas TA, et al. (2012 Apr). Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Visweswaraiah J, et al. (2012 Nov 2). Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation.

Jongjitwimol J, et al. (2014). The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lipp JJ, et al. (2015 Aug). SR protein kinases promote splicing of nonconsensus introns.

Lucena R, et al. (2015 May 11). Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.

Nie M, et al. (2015 Sep 25). High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%