FOG02089
EOG8612KR

sce:PAH1

Genes: 37

SGD Description
Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2


PomBase Description
lipin, phosphatidate phosphatase Ned1


AspGD Description
Ortholog(s) have role in endoplasmic reticulum organization, nucleus organization and cytosol localization


References

Irie K, et al. (1993 Jan). A gene, SMP2, involved in plasmid maintenance and respiration in Saccharomyces cerevisiae encodes a highly charged protein.

Santos-Rosa H, et al. (2005 Jun 1). The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth.

Han GS, et al. (2006 Apr 7). The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme.

O'Hara L, et al. (2006 Nov 10). Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase.

Han GS, et al. (2007 Dec 21). The cellular functions of the yeast lipin homolog PAH1p are dependent on its phosphatidate phosphatase activity.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Havriluk T, et al. (2008 Feb 15). Colorimetric determination of pure Mg(2+)-dependent phosphatidate phosphatase activity.

Karanasios E, et al. (2010 Oct 12). A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Choi HS, et al. (2011 Jan 14). Phosphorylation of phosphatidate phosphatase regulates its membrane association and physiological functions in Saccharomyces cerevisiae: identification of SER(602), THR(723), AND SER(744) as the sites phosphorylated by CDC28 (CDK1)-encoded cyclin-dependent kinase.

Adeyo O, et al. (2011 Mar 21). The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%