FOG02077
EOG8547J1

sce:LDH1

Genes: 32

SGD Description
Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)


PomBase Description
carboxylic ester hydrolase activity (predicted)


AspGD Description
Has domain(s) with predicted phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity and role in dephosphorylation, protein dephosphorylation


References

Baxter SM, et al. (2004 Mar). Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Debelyy MO, et al. (2011 Jun). Involvement of the Saccharomyces cerevisiae hydrolase Ldh1p in lipid homeostasis.

Thoms S, et al. (2011 Jun). The putative Saccharomyces cerevisiae hydrolase Ldh1p is localized to lipid droplets.

Fang Y, et al. (2012 Apr). A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 8 genes with posterior transmembrane prediction > 50%