FOG02071
EOG8STQMK

sce:TGL4;TGL5

Genes: 34

SGD Description
Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p; TGL4 has a paralog, TGL5, that arose from the whole genome duplication|Bifunctional triacylglycerol lipase and LPA acyltransferase; lipid particle-localized triacylglycerol (TAG) lipase involved in triacylglycerol mobilization; catalyzes acylation of lysophosphatidic acid (LPA); potential Cdc28p substrate; TGL5 has a paralog, TGL4, that arose from the whole genome duplication


PomBase Description
triacylglycerol lipase ptl3


AspGD Description
Ortholog(s) have calcium-independent phospholipase A2 activity, lysophosphatidic acid acyltransferase activity, sterol esterase activity, triglyceride lipase activity


References

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Athenstaedt K, et al. (2005 Nov 11). Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Yazawa H, et al. (2012 Nov). Characterization of triglyceride lipase genes of fission yeast Schizosaccharomyces pombe.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%

FOG02072
EOG863XTF
EOG8STQMK

sce:TGL3

Genes: 33

Protein description
Bifunctional triacylglycerol lipase and LPE acyltransferase


SGD Description
Bifunctional triacylglycerol lipase and LPE acyltransferase; major lipid particle-localized triacylglycerol (TAG) lipase; catalyzes acylation of lysophosphatidylethanolamine (LPE), a function which is essential for sporulation; protein level and stability of Tgl3p are markedly reduced in the absence of lipid droplets; required with Tgl4p for timely bud formation


PomBase Description
triacylglycerol lipase ptl1


AspGD Description
Ortholog(s) have lysophosphatidylethanolamine acyltransferase activity, triglyceride lipase activity, role in cell budding, triglyceride catabolic process, triglyceride mobilization and lipid particle localization


References

Heinemeyer W, et al. (1994 Oct 11). PRE5 and PRE6, the last missing genes encoding 20S proteasome subunits from yeast? Indication for a set of 14 different subunits in the eukaryotic proteasome core.

Athenstaedt K, et al. (1999 Oct). Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae.

Athenstaedt K, et al. (2003 Jun 27). YMR313c/TGL3 encodes a novel triacylglycerol lipase located in lipid particles of Saccharomyces cerevisiae.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Yazawa H, et al. (2012 Nov). Characterization of triglyceride lipase genes of fission yeast Schizosaccharomyces pombe.

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Převorovský M, et al. (2015). Fission Yeast CSL Transcription Factors: Mapping Their Target Genes and Biological Roles.

Burr R, et al. (2016 Jun 3). Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 32 genes with posterior transmembrane prediction > 50%