FOG02066
EOG870S0G

sce:TAZ1

Genes: 32

SGD Description
Lyso-phosphatidylcholine acyltransferase; required for normal phospholipid content of mitochondrial membranes; major determinant of the final acyl chain composition of the mitochondrial-specific phospholipid cardiolipin; mutations in human ortholog tafazzin cause Barth syndrome, a rare X-linked disease characterized by skeletal and cardiomyopathy and bouts of cyclic neutropenia


AspGD Description
Ortholog(s) have 1-acylglycerophosphocholine O-acyltransferase activity


References

Richard MG, et al. (1998 Dec). Lysophosphatidylcholine acyltransferase activity in Saccharomyces cerevisiae: regulation by a high-affinity Zn2+ binding site.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Gu Z, et al. (2004 Jan). Aberrant cardiolipin metabolism in the yeast taz1 mutant: a model for Barth syndrome.

Testet E, et al. (2005 May 1). Ypr140wp, 'the yeast tafazzin', displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis.

Brandner K, et al. (2005 Nov). Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 22 genes with posterior transmembrane prediction > 50%

FOG02067
EOG870S0G
EOG8ZS7KX

sce:absent

Genes: 3

AspGD Description
Ortholog of Aspergillus carbonarius ITEM 5010 : Acar5010_512192

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02068
EOG8ZS7KX

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%