FOG01987
EOG85TB3Q

sce:ERG4

Genes: 34

SGD Description
C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol


PomBase Description
C-24(28) sterol reductase Sts1


AspGD Description
Ortholog(s) have delta24(24-1) sterol reductase activity|C-24 sterol reductase


References

Chen WN, et al. (1991 Apr). The YGL022 gene encodes a putative transport protein.

Toda T, et al. (1991 Jan). Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.

Shimanuki M, et al. (1992 Mar). Fission yeast sts1+ gene encodes a protein similar to the chicken lamin B receptor and is implicated in pleiotropic drug-sensitivity, divalent cation-sensitivity, and osmoregulation.

Yoshida T, et al. (1994 Jul). A calcineurin-like gene ppb1+ in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning.

Lai MH, et al. (1994 Mar 11). The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Iwaki T, et al. (2008 Mar). Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe.

Fang Y, et al. (2009 Jun). Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast.

Takami T, et al. (2012). A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast.

Fang Y, et al. (2012 Apr). A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Doi A, et al. (2015 Apr). Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.

Guo L, et al. (2016 Oct 13). Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 34 genes with posterior transmembrane prediction > 50%