FOG01982
EOG8RXWGF

sce:ERG6

Genes: 34

SGD Description
Delta(24)-sterol C-methyltransferase; converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to lipid particles, the plasma membrane-associated endoplasmic reticulum, and the mitochondrial outer membrane


PomBase Description
sterol 24-C-methyltransferase Erg6


AspGD Description
S-adenosyl-methionine delta-24-sterol-C-methyltransferase


References

Hussain M, et al. (1991 May 15). Characterization of PDR4, a Saccharomyces cerevisiae gene that confers pleiotropic drug resistance in high-copy number: identity with YAP1, encoding a transcriptional activator [corrected].

Hardwick KG, et al. (1994 Feb). SED6 is identical to ERG6, and encodes a putative methyltransferase required for ergosterol synthesis.

Welihinda AA, et al. (1994 Jul 13). Mutations in LIS1 (ERG6) gene confer increased sodium and lithium uptake in Saccharomyces cerevisiae.

Garrels JI, et al. (1997 Aug). Proteome studies of Saccharomyces cerevisiae: identification and characterization of abundant proteins.

Jensen-Pergakes KL, et al. (1998 May). Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants.

Mo C, et al. (2004 Nov 8). The ERG28-encoded protein, Erg28p, interacts with both the sterol C-4 demethylation enzyme complex as well as the late biosynthetic protein, the C-24 sterol methyltransferase (Erg6p).

Mo C, et al. (2005 Sep). Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex.

Iwaki T, et al. (2008 Mar). Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Takami T, et al. (2012). A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%