FOG01981
EOG80RXX9

sce:ERG27

Genes: 33

SGD Description
3-keto sterol reductase; catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs


PomBase Description
3-keto sterol reductase Erg27 (predicted)


AspGD Description
Has domain(s) with predicted oxidoreductase activity and role in metabolic process


References

Gachotte D, et al. (1999 Oct 26). Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.

Mo C, et al. (2002 Jul 23). Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis.

Mo C, et al. (2003 Jul 4). In yeast sterol biosynthesis the 3-keto reductase protein (Erg27p) is required for oxidosqualene cyclase (Erg7p) activity.

Natter K, et al. (2005 May). The spatial organization of lipid synthesis in the yeast Saccharomyces cerevisiae derived from large scale green fluorescent protein tagging and high resolution microscopy.

Mo C, et al. (2005 Sep). Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%