FOG01974
EOG83J9M9

sce:ERG11

Genes: 35

SGD Description
Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p


PomBase Description
sterol 14-demethylase Erg11 (predicted)


AspGD Description
Cytochrome p450 lanosterol 14A-demethylase|Ortholog(s) have drug binding, sterol 14-demethylase activity and role in cell growth mode switching, budding to filamentous, cellular response to drug, ergosterol biosynthetic process, membrane raft polarization


References

Kalb VF, et al. (1986). Isolation of a cytochrome P-450 structural gene from Saccharomyces cerevisiae.

Kalb VF, et al. (1987 Dec). Primary structure of the P450 lanosterol demethylase gene from Saccharomyces cerevisiae.

Ishida N, et al. (1988 Aug 30). A single amino acid substitution converts cytochrome P450(14DM) to an inactive form, cytochrome P450SG1: complete primary structures deduced from cloned DNAS.

Lai MH, et al. (1989 Jan 25). Nucleotide sequence of cytochrome P450 L1A1 (lanosterol 14 alpha-demethylase) from Candida albicans.

Burgener-Kairuz P, et al. (1994 Aug). Rapid detection and identification of Candida albicans and Torulopsis (Candida) glabrata in clinical specimens by species-specific nested PCR amplification of a cytochrome P-450 lanosterol-alpha-demethylase (L1A1) gene fragment.

Boscott PE, et al. (1994 Sep). Modeling cytochrome P450 14 alpha demethylase (Candida albicans) from P450cam.

Geber A, et al. (1995 Dec). Deletion of the Candida glabrata ERG3 and ERG11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility.

White TC, et al. (1997 Jul). The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicans.

Löffler J, et al. (1997 Jun 15). Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains.

Mellado E, et al. (2001 Jul). Identification of two different 14-alpha sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species.

Osherov N, et al. (2001 Jul). Resistance to itraconazole in Aspergillus nidulans and Aspergillus fumigatus is conferred by extra copies of the A. nidulans P-450 14alpha-demethylase gene, pdmA.

Hughes AL, et al. (2005 Mar 25). SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.

Mo C, et al. (2005 Sep). Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex.

Todd BL, et al. (2006 Apr). Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Hughes AL, et al. (2007 Feb). Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Savoldi M, et al. (2008 Oct). Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase.

Kelly DE, et al. (2009 Mar). The CYPome (Cytochrome P450 complement) of Aspergillus nidulans.

Ren L, et al. (2011 Feb 28). Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Lando D, et al. (2012). The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Vermeulen E, et al. (2012 Nov 29). Azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation emerging in Belgium, July 2012.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Zhang X, et al. (2015 Oct 9). Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.

Silva DB, et al. (2016 Mar). Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Singh A, et al. (2017 Nov). Novel Cell-Killing Mechanisms of Hydroxyurea and the Implication toward Combination Therapy for the Treatment of Fungal Infections.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 31 genes with posterior transmembrane prediction > 50%