FOG01964
EOG8PRRB7

sce:COX15

Genes: 33

SGD Description
Protein required for the hydroxylation of heme O to form heme A; heme A is an essential prosthetic group for cytochrome c oxidase


PomBase Description
mitochondrial type I (2Fe-2S) ferredoxin Etp1/ cytochrome oxidase cofactor Cox15, fusion protein


AspGD Description
Ortholog(s) have electron carrier activity, oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor activity and role in electron transport chain, heme a biosynthetic process


References

Glerum DM, et al. (1997 Jul 25). COX15 codes for a mitochondrial protein essential for the assembly of yeast cytochrome oxidase.

Barros MH, et al. (2001 Mar 9). Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation of heme O.

Wu G, et al. (2002 Apr). Iron-sulfur cluster biosynthesis: characterization of Schizosaccharomyces pombe Isa1.

Wu G, et al. (2002 Apr 16). Characterization of an iron-sulfur cluster assembly protein (ISU1) from Schizosaccharomyces pombe.

Bureik M, et al. (2002 Feb 19). Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1.

Wu SP, et al. (2002 Jul 16). Iron-sulfur cluster biosynthesis. Kinetic analysis of [2Fe-2S] cluster transfer from holo ISU to apo Fd: role of redox chemistry and a conserved aspartate.

Wu SP, et al. (2003 May 20). Iron-sulfur cluster biosynthesis. A comparative kinetic analysis of native and Cys-substituted ISA-mediated [2Fe-2S]2+ cluster transfer to an apoferredoxin target.

Schiffler B, et al. (2004 Jul). The adrenodoxin-like ferredoxin of Schizosaccharomyces pombe mitochondria.

Wilhelm BT, et al. (2008 Jun 26). Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.

Ewen KM, et al. (2008 May). The endogenous adrenodoxin reductase-like flavoprotein arh1 supports heterologous cytochrome P450-dependent substrate conversions in Schizosaccharomyces pombe.

Müller JJ, et al. (2011 Jul). Structural and thermodynamic characterization of the adrenodoxin-like domain of the electron-transfer protein Etp1 from Schizosaccharomyces pombe.

Wu SP, et al. (2011 Jun). Redox chemistry of the Schizosaccharomyces pombe ferredoxin electron-transfer domain and influence of Cys to Ser substitutions.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%

FOG01965
EOG8PRRB7

sce:YAH1

Genes: 32

Protein description
Used in fatty acid hydroxylation


SGD Description
Ferredoxin of the mitochondrial matrix; required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin


AspGD Description
Ortholog(s) have oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor activity, role in heme a biosynthetic process, iron-sulfur cluster assembly, ubiquinone biosynthetic process and mitochondrial matrix localization


References

Barros MH, et al. (1999 Jun 11). YAH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to human adrenodoxin.

Lange H, et al. (2000 Feb 1). A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%