FOG01945
EOG8N2Z6Q

sce:COQ5

Genes: 33

SGD Description
2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes


PomBase Description
C-methyltransferase (predicted)


AspGD Description
Ortholog(s) have 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity, role in aerobic respiration, cellular response to drug, ubiquinone biosynthetic process and mitochondrial matrix localization


References

Barkovich RJ, et al. (1997 Apr 4). Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis.

Dibrov E, et al. (1997 Apr 4). The COQ5 gene encodes a yeast mitochondrial protein necessary for ubiquinone biosynthesis and the assembly of the respiratory chain.

Baba SW, et al. (2004 Mar 12). Yeast Coq5 C-methyltransferase is required for stability of other polypeptides involved in coenzyme Q biosynthesis.

Zuin A, et al. (2008 Jul 30). Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

Kennedy PJ, et al. (2008 Nov). A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Buttrick GJ, et al. (2011 Dec). Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Karachaliou M, et al. (2013 Apr). The arrestin-like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad-range and specific signals.

Hayashi K, et al. (2014). Functional conservation of coenzyme Q biosynthetic genes among yeasts, plants, and humans.

He CH, et al. (2014 Apr 4). Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Dai YN, et al. (2014 Aug). Crystal structures and catalytic mechanism of the C-methyltransferase Coq5 provide insights into a key step of the yeast coenzyme Q synthesis pathway.

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Moriyama D, et al. (2015). Production of CoQ10 in fission yeast by expression of genes responsible for CoQ10 biosynthesis.

Zhang X, et al. (2015 Oct 9). Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Guo L, et al. (2016 Oct 13). Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%