FOG01868
EOG8HT785

sce:RAM1

Genes: 32

Protein description
Beta subunit of the CAAX farnesyltransferase (FTase)


SGD Description
Beta subunit of the CAAX farnesyltransferase (FTase); this complex prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit


PomBase Description
protein farnesyltransferase beta subunit Cpp1


AspGD Description
Ortholog(s) have protein farnesyltransferase activity, role in protein farnesylation and cytosol, nucleus, protein farnesyltransferase complex localization


References

Goodman LE, et al. (1988 Dec). Structure and expression of yeast DPR1, a gene essential for the processing and intracellular localization of ras proteins.

Dyer PS, et al. (2003 Sep). Genomics reveals sexual secrets of Aspergillus.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%

FOG01869
EOG8HT785
EOG8MKKZM

sce:CDC43

Genes: 33

SGD Description
Beta subunit of geranylgeranyltransferase type I; catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis


PomBase Description
geranylgeranyltransferase I beta subunit Cwg2


AspGD Description
Ortholog(s) have CAAX-protein geranylgeranyltransferase activity, role in glucan biosynthetic process, protein geranylgeranylation and CAAX-protein geranylgeranyltransferase complex, cytosol, nucleus localization


References

Johnson DI, et al. (1990 May 31). Isolation and sequence analysis of CDC43, a gene involved in the control of cell polarity in Saccharomyces cerevisiae.

Johnson DI, et al. (1991 Feb 1). Isolation and sequence analysis of CDC43, a gene involved in the control of cell polarity in Saccharomyces cerevisiae.

Ohya Y, et al. (1991 Jul 5). Yeast CAL1 is a structural and functional homologue to the DPR1 (RAM) gene involved in ras processing.

Ribas JC, et al. (1991 Jun). Isolation and characterization of Schizosaccharomyces pombe mutants defective in cell wall (1-3)beta-D-glucan.

Finegold AA, et al. (1991 May 15). Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product.

Díaz M, et al. (1993 Dec 15). The Schizosaccharomyces pombe cwg2+ gene codes for the beta subunit of a geranylgeranyltransferase type I required for beta-glucan synthesis.

Verde F, et al. (1995 Dec). Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle.

Arellano M, et al. (1996 Sep 2). Rho 1 GTPase activates the (1-3)beta-D-glucan synthase and is involved in Schizosaccharomyces pombe morphogenesis.

Arellano M, et al. (1998 Sep). Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe.

Doi A, et al. (2015 Apr). Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 13 genes with posterior transmembrane prediction > 50%