FOG01807
EOG8FTTG9
sce:GAS1
Genes: 53
EOG8FTTG9
sce:GAS1
Genes: 53
SGD Description
Beta-1,3-glucanosyltransferase; required for cell wall assembly and also has a role in transcriptional silencing; localizes to cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at nuclear periphery; genetic interactions with histone H3 lysine acetyltransferases GCN5 and SAS3 indicate previously unsuspected functions for Gas1 in DNA damage response and cell cycle regulation
PomBase Description
cell wall protein Gas1, 1,3-beta-glucanosyltransferase (predicted)
AspGD Description
Putative 1,3-beta-glucanosyltransferase; predicted signal peptide secretion sequence|Putative 1,3-beta-glucanosyltransferase; secreted protein|Putative 1,3-beta-glucanosyltransferase; predicted signal peptide secretion sequence|Putative 1,3-beta-glucanosyltransferase; predicted signal peptide secretion sequence; secreted protein
References
Popolo L, et al. (1988 Dec). Immunochemical characterization of gp115, a yeast glycoprotein modulated by the cell cycle.
Conzelmann A, et al. (1988 Jul). A major 125-kd membrane glycoprotein of Saccharomyces cerevisiae is attached to the lipid bilayer through an inositol-containing phospholipid.
Vai M, et al. (1990 May 8). The cell cycle modulated glycoprotein GP115 is one of the major yeast proteins containing glycosylphosphatidylinositol.
Nuoffer C, et al. (1991 Jan). Determinants for glycophospholipid anchoring of the Saccharomyces cerevisiae GAS1 protein to the plasma membrane.
Vai M, et al. (1991 Jul 5). Isolation and deduced amino acid sequence of the gene encoding gp115, a yeast glycophospholipid-anchored protein containing a serine-rich region.
Saporito-Irwin SM, et al. (1995 Feb). PHR1, a pH-regulated gene of Candida albicans, is required for morphogenesis.
Mühlschlegel FA, et al. (1997 Oct). PHR2 of Candida albicans encodes a functional homolog of the pH-regulated gene PHR1 with an inverted pattern of pH-dependent expression.
De Sampaïo G, et al. (1999 Oct). A constitutive role for GPI anchors in Saccharomyces cerevisiae: cell wall targeting.
Mouyna I, et al. (2000 May 19). Glycosylphosphatidylinositol-anchored glucanosyltransferases play an active role in the biosynthesis of the fungal cell wall.
Carotti C, et al. (2004 Sep). Characterization of recombinant forms of the yeast Gas1 protein and identification of residues essential for glucanosyltransferase activity and folding.
Yin QY, et al. (2005 May 27). Comprehensive proteomic analysis of Saccharomyces cerevisiae cell walls: identification of proteins covalently attached via glycosylphosphatidylinositol remnants or mild alkali-sensitive linkages.
Yin QY, et al. (2007 Sep). Mass spectrometric quantitation of covalently bound cell wall proteins in Saccharomyces cerevisiae.
Luallen RJ, et al. (2008 Jul). An engineered Saccharomyces cerevisiae strain binds the broadly neutralizing human immunodeficiency virus type 1 antibody 2G12 and elicits mannose-specific gp120-binding antibodies.
Popolo L, et al. (2008 Jul 4). Disulfide bond structure and domain organization of yeast beta(1,3)-glucanosyltransferases involved in cell wall biogenesis.
Silva EM, et al. (2008 Oct). Identification of genes differentially expressed in a strain of the mold Aspergillus nidulans carrying a loss-of-function mutation in the palA gene.
de Groot PW, et al. (2009 Mar). Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans.
Christians JK, et al. (2011 Apr 29). Quantitative trait locus (QTL) mapping reveals a role for unstudied genes in Aspergillus virulence.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.
Garzia A, et al. (2013 Feb). Transcriptional changes in the transition from vegetative cells to asexual development in the model fungus Aspergillus nidulans.
Szilágyi M, et al. (2013 Jan). Transcriptome changes initiated by carbon starvation in Aspergillus nidulans.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
49 genes with posterior transmembrane prediction > 50% |
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FOG01808
EOG8FTTG9
sce:GAS5
Genes: 34
EOG8FTTG9
sce:GAS5
Genes: 34
SGD Description
1,3-beta-glucanosyltransferase; has similarity to Gas1p; localizes to the cell wall
PomBase Description
cell wall protein Gas5, 1,3-beta-glucanosyltransferase (predicted)|sporulation specific 1,3-beta-glucanosyltransferase Gas4
AspGD Description
Putative 1,3-beta-glucanosyltransferase; predicted signal peptide secretion sequence; induced by caspofungin; expressed during germination
References
De Groot PW, et al. (2003 Jul 15). Genome-wide identification of fungal GPI proteins.
de Groot PW, et al. (2004 Aug). Proteomic analysis of Candida albicans cell walls reveals covalently bound carbohydrate-active enzymes and adhesins.
Yin QY, et al. (2005 May 27). Comprehensive proteomic analysis of Saccharomyces cerevisiae cell walls: identification of proteins covalently attached via glycosylphosphatidylinositol remnants or mild alkali-sensitive linkages.
Moreno I, et al. (2007 Apr). Global transcriptional profiling of Candida albicans cwt1 null mutant.
Ragni E, et al. (2007 Apr). The Gas family of proteins of Saccharomyces cerevisiae: characterization and evolutionary analysis.
de Groot PW, et al. (2007 Apr). Mass spectrometric identification of covalently bound cell wall proteins from the fission yeast Schizosaccharomyces pombe.
Fujioka T, et al. (2007 Aug). MpkA-Dependent and -independent cell wall integrity signaling in Aspergillus nidulans.
Zakikhany K, et al. (2007 Dec). In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination.
Eckert SE, et al. (2007 May). PGA4, a GAS homologue from Candida albicans, is up-regulated early in infection processes.
Sosinska GJ, et al. (2008 Feb). Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions.
Plaine A, et al. (2008 Oct). Functional analysis of Candida albicans GPI-anchored proteins: roles in cell wall integrity and caspofungin sensitivity.
Castillo L, et al. (2008 Sep). A study of the Candida albicans cell wall proteome.
de Groot PW, et al. (2009 Mar). Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans.
Sorgo AG, et al. (2010 Aug). Mass spectrometric analysis of the secretome of Candida albicans.
de Medina-Redondo M, et al. (2010 Nov 18). β(1,3)-glucanosyl-transferase activity is essential for cell wall integrity and viability of Schizosaccharomyces pombe.
Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Sorgo AG, et al. (2011 Aug). Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans.
Sosinska GJ, et al. (2011 Jan). Mass spectrometric quantification of the adaptations in the wall proteome of Candida albicans in response to ambient pH.
Freitas JS, et al. (2011 Sep). Transcription of the Hsp30, Hsp70, and Hsp90 heat shock protein genes is modulated by the PalA protein in response to acid pH-sensing in the fungus Aspergillus nidulans.
Ene IV, et al. (2012 Nov). Carbon source-induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen Candida albicans.
Yoshimi A, et al. (2013). Functional analysis of the α-1,3-glucan synthase genes agsA and agsB in Aspergillus nidulans: agsB is the major α-1,3-glucan synthase in this fungus.
Szilágyi M, et al. (2013 Jan). Transcriptome changes initiated by carbon starvation in Aspergillus nidulans.
Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
25 genes with posterior transmembrane prediction > 50% |
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FOG01809
EOG8FTTG9
sce:GAS4
Genes: 26
EOG8FTTG9
sce:GAS4
Genes: 26
SGD Description
1,3-beta-glucanosyltransferase; involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall
References
Hamada K, et al. (1999 Jul). Amino acid residues in the omega-minus region participate in cellular localization of yeast glycosylphosphatidylinositol-attached proteins.
Ragni E, et al. (2007 Apr). The Gas family of proteins of Saccharomyces cerevisiae: characterization and evolutionary analysis.
Ragni E, et al. (2007 Feb). GAS2 and GAS4, a pair of developmentally regulated genes required for spore wall assembly in Saccharomyces cerevisiae.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
12 genes with posterior transmembrane prediction > 50% |
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FOG01810
EOG8FTTG9
sce:GAS3
Genes: 25
EOG8FTTG9
sce:GAS3
Genes: 25
SGD Description
Putative 1,3-beta-glucanosyltransferase; has similarity go other GAS family members; low abundance, possibly inactive member of the GAS family of GPI-containing proteins; localizes to the cell wall; mRNA induced during sporulation
AspGD Description
Putative 1,3-beta-glucanosyltransferase; predicted signal peptide secretion sequence
References
Pardo M, et al. (2000 Oct). A proteomic approach for the study of Saccharomyces cerevisiae cell wall biogenesis.
Yin QY, et al. (2005 May 27). Comprehensive proteomic analysis of Saccharomyces cerevisiae cell walls: identification of proteins covalently attached via glycosylphosphatidylinositol remnants or mild alkali-sensitive linkages.
Ragni E, et al. (2007 Apr). The Gas family of proteins of Saccharomyces cerevisiae: characterization and evolutionary analysis.
Fujioka T, et al. (2007 Aug). MpkA-Dependent and -independent cell wall integrity signaling in Aspergillus nidulans.
Kung LA, et al. (2009). Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes.
de Groot PW, et al. (2009 Mar). Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans.
Yoshimi A, et al. (2013). Functional analysis of the α-1,3-glucan synthase genes agsA and agsB in Aspergillus nidulans: agsB is the major α-1,3-glucan synthase in this fungus.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
17 genes with posterior transmembrane prediction > 50% |
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FOG01811
EOG8FTTG9
sce:GAS2
Genes: 15
EOG8FTTG9
sce:GAS2
Genes: 15
SGD Description
1,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p
References
De Groot PW, et al. (2003 Jul 15). Genome-wide identification of fungal GPI proteins.
Ragni E, et al. (2007 Apr). The Gas family of proteins of Saccharomyces cerevisiae: characterization and evolutionary analysis.
Ragni E, et al. (2007 Feb). GAS2 and GAS4, a pair of developmentally regulated genes required for spore wall assembly in Saccharomyces cerevisiae.
Eckert SE, et al. (2007 May). PGA4, a GAS homologue from Candida albicans, is up-regulated early in infection processes.
Popolo L, et al. (2008 Jul 4). Disulfide bond structure and domain organization of yeast beta(1,3)-glucanosyltransferases involved in cell wall biogenesis.
Hurtado-Guerrero R, et al. (2009 Mar 27). Molecular mechanisms of yeast cell wall glucan remodeling.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
10 genes with posterior transmembrane prediction > 50% |
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FOG01812
EOG8FTTG9
sce:absent
Genes: 4
EOG8FTTG9
sce:absent
Genes: 4
AspGD Description
Putative 1,3-beta-glucanosyltransferase; predicted signal peptide secretion sequence
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
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FOG01813
EOG8FTTG9
sce:absent
Genes: 2
EOG8FTTG9
sce:absent
Genes: 2
PomBase Description
1,3-beta-glucanosyltransferase Gas2 (predicted)
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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