FOG01718
EOG89CNRG
[c]
sce:TRR1

Genes: 34

Protein description
Cytoplasmic thioredoxin reductase


SGD Description
Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication


PomBase Description
thioredoxin reductase Trr1


AspGD Description
Thioredoxin reductase; induced by growth on starch and lactate


References

Furter R, et al. (1986 Aug 26). The TRP4 gene of Saccharomyces cerevisiae: isolation and structural analysis.

Chae HZ, et al. (1994 Nov 4). Thioredoxin-dependent peroxide reductase from yeast.

Tarrío N, et al. (2004 May 25). Isolation and characterization of two nuclear genes encoding glutathione and thioredoxin reductases from the yeast Kluyveromyces lactis.

Thön M, et al. (2007 Sep 14). The thioredoxin system of the filamentous fungus Aspergillus nidulans: impact on development and oxidative stress response.

Hagiwara D, et al. (2008 Oct). Characterization of bZip-type transcription factor AtfA with reference to stress responses of conidia of Aspergillus nidulans.

Zhang Z, et al. (2009 Jan). Crystal structure of Saccharomyces cerevisiae cytoplasmic thioredoxin reductase Trr1 reveals the structural basis for species-specific recognition of thioredoxin.

Miskei M, et al. (2009 Mar). Annotation of stress-response proteins in the aspergilli.

Sato I, et al. (2009 Mar 20). The glutathione system of Aspergillus nidulans involves a fungus-specific glutathione S-transferase.

Oliveira MA, et al. (2010 Apr 20). Insights into the specificity of thioredoxin reductase-thioredoxin interactions. A structural and functional investigation of the yeast thioredoxin system.

Oh YT, et al. (2010 Mar). Proteomic analysis of early phase of conidia germination in Aspergillus nidulans.

Thön M, et al. (2010 Mar). The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Vögtle FN, et al. (2012 Dec). Intermembrane space proteome of yeast mitochondria.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01719
EOG89CNRG
[m]
sce:TRR2

Genes: 1

Protein description
Mitochondrial thioredoxin reductase


Parent
ohnolog:FOG01718


SGD Description
Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication


References

Pedrajas JR, et al. (1999 Mar 5). Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%