FOG01713
EOG89S4RB

sce:HYR1;GPX2

Genes: 37

SGD Description
Thiol peroxidase; functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor; HYR1 has a paralog, GPX1, that arose from the whole genome duplication|Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress


PomBase Description
glutathione peroxidase Gpx1


AspGD Description
Ortholog(s) have glutathione peroxidase activity, phospholipid-hydroperoxide glutathione peroxidase activity, thioredoxin peroxidase activity


References

Ursini F, et al. (1997 Sep). Phospholipid hydroperoxide glutathione peroxidase (PHGPx): more than an antioxidant enzyme?

Yamada K, et al. (1999 Aug). Schizosaccharomyces pombe homologue of glutathione peroxidase, which does not contain selenocysteine, is induced by several stresses and works as an antioxidant.

Inoue Y, et al. (1999 Sep 17). Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae.

Buck V, et al. (2001 Feb). Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway.

Avery AM, et al. (2001 Sep 7). Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases.

Mutoh N, et al. (2002 May). Characterization of Cu, Zn-superoxide dismutase-deficient mutant of fission yeast Schizosaccharomyces pombe.

Delaunay A, et al. (2002 Nov 15). A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation.

Greenall A, et al. (2002 Sep). Role of fission yeast Tup1-like repressors and Prr1 transcription factor in response to salt stress.

Veal EA, et al. (2003 Aug 15). Ybp1 is required for the hydrogen peroxide-induced oxidation of the Yap1 transcription factor.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Azevedo D, et al. (2003 Oct 15). Two redox centers within Yap1 for H2O2 and thiol-reactive chemicals signaling.

Avery AM, et al. (2004 Nov 5). Genetic dissection of the phospholipid hydroperoxidase activity of yeast gpx3 reveals its functional importance.

Tanaka T, et al. (2005 Dec 23). GPX2, encoding a phospholipid hydroperoxide glutathione peroxidase homologue, codes for an atypical 2-Cys peroxiredoxin in Saccharomyces cerevisiae.

Rodríguez-Gabriel MA, et al. (2006 Sep). Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast.

Ma LH, et al. (2007 Oct 26). Molecular mechanism of oxidative stress perception by the Orp1 protein.

Zhang WJ, et al. (2008 Dec). Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae.

Lee SY, et al. (2008 Feb 29). Gpx1 is a stationary phase-specific thioredoxin peroxidase in fission yeast.

Miki R, et al. (2008 Nov). Comparison of a coq7 deletion mutant with other respiration-defective mutants in fission yeast.

Paulsen CE, et al. (2009 Feb 27). Chemical dissection of an essential redox switch in yeast.

Miskei M, et al. (2009 Mar). Annotation of stress-response proteins in the aspergilli.

Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Balázs A, et al. (2010 Mar). AtfA bZIP-type transcription factor regulates oxidative and osmotic stress responses in Aspergillus nidulans.

Kim JS, et al. (2010 Mar). Distinct functional roles of peroxiredoxin isozymes and glutathione peroxidase from fission yeast, Schizosaccharomyces pombe.

Thön M, et al. (2010 Mar). The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes.

Zuin A, et al. (2010 Mar 3). Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Ukai Y, et al. (2011 Aug 5). Glutathione peroxidase 2 in Saccharomyces cerevisiae is distributed in mitochondria and involved in sporulation.

Quinn J, et al. (2011 Jul 1). Two-component mediated peroxide sensing and signal transduction in fission yeast.

Vögtle FN, et al. (2012 Dec). Intermembrane space proteome of yeast mitochondria.

Wartenberg D, et al. (2012 Jul 16). Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin.

Ohdate T, et al. (2012 Sep). Involvement of glutathione peroxidase 1 in growth and peroxisome formation in Saccharomyces cerevisiae in oleic acid medium.

Fernández-Vázquez J, et al. (2013). Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs.

Kato H, et al. (2013). The transcription factors Atf1 and Pcr1 are essential for transcriptional induction of the extracellular maltase Agl1 in fission yeast.

Calvo IA, et al. (2013 Dec 12). Dissection of a redox relay: H2O2-dependent activation of the transcription factor Pap1 through the peroxidatic Tpx1-thioredoxin cycle.

Paulo E, et al. (2014 Apr). A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01714
EOG89S4RB

sce:absent

Genes: 4

References

Patterson MJ, et al. (2013 Dec 20). Ybp1 and Gpx3 signaling in Candida albicans govern hydrogen peroxide-induced oxidation of the Cap1 transcription factor and macrophage escape.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01715
EOG89S4RB

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG01716
EOG89S4RB

sce:GPX1

Genes: 1

SGD Description
Phospholipid hydroperoxide glutathione peroxidase; induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; GPX1 has a paralog, HYR1, that arose from the whole genome duplication


References

Inoue Y, et al. (1999 Sep 17). Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae.

Avery AM, et al. (2001 Sep 7). Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases.

Ohdate T, et al. (2010 Sep). Kinetics and redox regulation of Gpx1, an atypical 2-Cys peroxiredoxin, in Saccharomyces cerevisiae.

Ohdate T, et al. (2012 Sep). Involvement of glutathione peroxidase 1 in growth and peroxisome formation in Saccharomyces cerevisiae in oleic acid medium.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01717
EOG89S4RB

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%