FOG01686
EOG88KPSH
sce:MET12
Genes: 33
EOG88KPSH
sce:MET12
Genes: 33
SGD Description
Protein with MTHFR activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of methylenetetrahydrofolate reductase (MTHFR)
PomBase Description
methylenetetrahydrofolate reductase Met11
AspGD Description
Methylenetetrahydrofolate reductase (NADPH)
References
Putrament A, et al. (1970). Further genetic characteristics of methionine mutants and their suppressors in Aspergillus nidulans.
Putrament A, et al. (1971 Apr). The highly polarized recombination pattern within the methA gene of Aspergillus nidulans. Recombination within the methA cistron of A. nidulans.
Bal J, et al. (1979 Dec). Allele specific and locus non-specific suppressors in Aspergillus nidulans.
Benigni R, et al. (1979 Nov). Mutational studies with diquat and paraquat in vitro.
Bignami M, et al. (1982 Aug). Evaluation of 2 different genetic markers for the detection of frameshift and missense mutagens in A. nidulans.
Yang E, et al. (1984 Oct). Molecular cloning and nucleotide sequence analysis of the Saccharomyces cerevisiae RAD1 gene.
Nadolska-Lutyk J, et al. (1989 Apr 15). Interrelated regulation of sulphur-containing amino-acid biosynthetic enzymes and folate-metabolizing enzymes in Aspergillus nidulans.
Paszewski A, et al. (1994). Sulphur metabolism.
Goyette P, et al. (1994 Aug). Human methylenetetrahydrofolate reductase: isolation of cDNA mapping and mutation identification.
Goyette P, et al. (1994 Jun). Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification.
Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.
Natorff R, et al. (1998 Feb). The Aspergillus nidulans sulphur regulatory gene sconB encodes a protein with WD40 repeats and an F-box.
Naula N, et al. (2002 Jul). Two non-complementing genes encoding enzymatically active methylenetetrahydrofolate reductases control methionine requirement in fission yeast Schizosaccharomyces pombe.
Sieńko M, et al. (2007 Jul). Two Aspergillus nidulans genes encoding methylenetetrahydrofolate reductases are up-regulated by homocysteine.
Zuin A, et al. (2008 Jul 30). Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Frandsen RJ, et al. (2010 Aug). Methylenetetrahydrofolate reductase activity is involved in the plasma membrane redox system required for pigment biosynthesis in filamentous fungi.
Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.
Brzywczy J, et al. (2011 Feb). Novel mutations reveal two important regions in Aspergillus nidulans transcriptional activator MetR.
Yaliwal LV, et al. (2012 Jan). Methylenetetrahydrofolate reductase mutations, a genetic cause for familial recurrent neural tube defects.
Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG01687
EOG88KPSH
sce:MET13
Genes: 32
EOG88KPSH
sce:MET13
Genes: 32
SGD Description
Major isozyme of methylenetetrahydrofolate reductase; catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
PomBase Description
methylenetetrahydrofolate reductase Met9
AspGD Description
Methylenetetrahydrofolate reductase (NADPH)
References
Kohli J, et al. (1977 Nov). Genetic Mapping in SCHIZOSACCHAROMYCES POMBE by Mitotic and Meiotic Analysis and Induced Haploidization.
Kitakawa M, et al. (1997 Apr 15). Identification and characterization of the genes for mitochondrial ribosomal proteins of Saccharomyces cerevisiae.
Raymond RK, et al. (1999 Dec 15). Saccharomyces cerevisiae expresses two genes encoding isozymes of methylenetetrahydrofolate reductase.
Roje S, et al. (2002 Feb 8). Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo.
Naula N, et al. (2002 Jul). Two non-complementing genes encoding enzymatically active methylenetetrahydrofolate reductases control methionine requirement in fission yeast Schizosaccharomyces pombe.
Sieńko M, et al. (2007 Jul). Two Aspergillus nidulans genes encoding methylenetetrahydrofolate reductases are up-regulated by homocysteine.
Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Frandsen RJ, et al. (2010 Aug). Methylenetetrahydrofolate reductase activity is involved in the plasma membrane redox system required for pigment biosynthesis in filamentous fungi.
Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Yaliwal LV, et al. (2012 Jan). Methylenetetrahydrofolate reductase mutations, a genetic cause for familial recurrent neural tube defects.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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