FOG01673
EOG8NGF5R

sce:DFR1

Genes: 29

SGD Description
Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism


AspGD Description
Putative dihydrofolate reductase (DHFR)


References

Lagosky PA, et al. (1987 Dec 23). Molecular characterization of the Saccharomyces cerevisiae dihydrofolate reductase gene (DFR1).

Barclay BJ, et al. (1988 Mar 31). Mapping and sequencing of the dihydrofolate reductase gene (DFR1) of Saccharomyces cerevisiae.

Fling ME, et al. (1988 Mar 31). Nucleotide sequence of the dihydrofolate reductase gene of Saccharomyces cerevisiae.

Liu J, et al. (2008 Sep 22). Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase.

Liu J, et al. (2009 Jan). Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors.

Paulsen JL, et al. (2011 Oct). Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity.

Paulsen JL, et al. (2013 Mar 1). Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.

G-Dayanandan N, et al. (2014 Mar 27). Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG01674
EOG8NGF5R
EOG8ZGMX1

sce:FSH3;FSH2

Genes: 40

SGD Description
Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2|Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2


PomBase Description
dihydrofolate reductase/ serine hydrolase family fusion protein Dfr1|serine hydrolase-like


AspGD Description
Ortholog of S. cerevisiae : FSH3, A. nidulans FGSC A4 : AN4776, A. fumigatus Af293 : Afu3g06620, A. niger CBS 513.88 : An18g00880 and A. oryzae RIB40 : AO090020000337|Ortholog of A. nidulans FGSC A4 : AN4776, A. fumigatus Af293 : Afu3g06620, A. niger CBS 513.88 : An11g09680, A. oryzae RIB40 : AO090020000337 and Aspergillus wentii : Aspwe1_0563966


References

Chéret G, et al. (1996 Sep). DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae.

Baxter SM, et al. (2004 Mar). Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast.

Zaim J, et al. (2005 Jan 7). Identification of new genes regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae.

Lando D, et al. (2012). The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Převorovský M, et al. (2015). Fission Yeast CSL Transcription Factors: Mapping Their Target Genes and Biological Roles.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG01675
EOG8ZGMX1

sce:absent

Genes: 1

AspGD Description
Protein of unknown function

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%