FOG01669
EOG8P8D2F

sce:MET7

Genes: 33

SGD Description
Folylpolyglutamate synthetase; catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; protein abundance increases in response to DNA replication stress


PomBase Description
folylpolyglutamate synthase (predicted)


AspGD Description
Tetrahydrofolylpolyglutamate synthase


References

DeSouza L, et al. (2000 Apr 15). Disruption of cytoplasmic and mitochondrial folylpolyglutamate synthetase activity in Saccharomyces cerevisiae.

Cherest H, et al. (2000 May 12). Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae.

Askree SH, et al. (2004 Jun 8). A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 13 genes with posterior transmembrane prediction > 50%

FOG01670
EOG8P8D2F

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01671
EOG87PVQF
EOG8P8D2F

sce:MIC60

Genes: 34

SGD Description
Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin


PomBase Description
human mitofilin ortholog (predicted)


AspGD Description
Ortholog(s) have role in cristae formation, protein import into mitochondrial intermembrane space and MICOS complex, mitochondrial crista, mitochondrial crista junction, plasma membrane localization


References

Reinders J, et al. (2006 Jul). Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.

Rabl R, et al. (2009 Jun 15). Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g.

Hess DC, et al. (2009 Mar). Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis.

Hoppins S, et al. (2011 Oct 17). A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria.

Harner M, et al. (2011 Oct 18). The mitochondrial contact site complex, a determinant of mitochondrial architecture.

von der Malsburg K, et al. (2011 Oct 18). Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis.

Pfanner N, et al. (2014 Mar 31). Uniform nomenclature for the mitochondrial contact site and cristae organizing system.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 31 genes with posterior transmembrane prediction > 50%

FOG01672
EOG8P8D2F

sce:absent

Genes: 2

AspGD Description
Tetrahydrofolylpolyglutamate synthase|Tetrahydrofolylpolyglutamate synthase

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%