FOG01648
EOG84QRFT

sce:CAB4

Genes: 31

SGD Description
Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable pantetheine-phosphate adenylyltransferase (PPAT); PPAT catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved


PomBase Description
cytidylyltransferase (predicted)


References

Hazbun TR, et al. (2003 Dec). Assigning function to yeast proteins by integration of technologies.

Wilhelm BT, et al. (2008 Jun 26). Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.

Olzhausen J, et al. (2009 Apr). Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%

FOG01649
EOG84QRFT

sce:ELP2

Genes: 34

SGD Description
Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin


PomBase Description
elongator complex subunit Elp2 (predicted)


AspGD Description
Ortholog(s) have microtubule binding activity, role in protein urmylation, regulation of transcription from RNA polymerase II promoter, tRNA wobble uridine modification and Elongator holoenzyme complex, cytosol, nucleus localization


References

Otero G, et al. (1999 Jan). Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.

Frohloff F, et al. (2001 Apr 17). Saccharomyces cerevisiae Elongator mutations confer resistance to the Kluyveromyces lactis zymocin.

Winkler GS, et al. (2001 Aug 31). RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes.

Krogan NJ, et al. (2001 Dec). Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae.

Fichtner L, et al. (2002 Aug). Protein interactions within Saccharomyces cerevisiae Elongator, a complex essential for Kluyveromyces lactis zymocicity.

Winkler GS, et al. (2002 Mar 19). Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo.

Klassen R, et al. (2003 Nov). Structural and functional analysis of the killer element pPin1-3 from Pichia inositovora.

Petrakis TG, et al. (2004 Jul 30). Molecular architecture, structure-function relationship, and importance of the Elp3 subunit for the RNA binding of holo-elongator.

Huang B, et al. (2005 Apr). An early step in wobble uridine tRNA modification requires the Elongator complex.

Rahl PB, et al. (2005 Mar 18). Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%