FOG01632
EOG8RFJBB

sce:PNC1

Genes: 31

SGD Description
Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress


PomBase Description
nicotinamidase Pnc1 (predicted)


AspGD Description
Protein with similarity to pyrazinamidase or nicotinamidase


References

Bernheim ML, et al. (1967 Apr). Hydrolysis of nicotinyl hydroxamate by a yeast nicotinamidase.

Calbreath DF, et al. (1971 Jul 10). Inhibition of nicotinamidase by nicotinamide adenine dinucleotide.

Ghislain M, et al. (2002 Feb). Identification and functional analysis of the Saccharomyces cerevisiae nicotinamidase gene, PNC1.

Anderson RM, et al. (2003 May 8). Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.

Gallo CM, et al. (2004 Feb). Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity.

Hu G, et al. (2007 May 1). Crystal structure of the yeast nicotinamidase Pnc1p.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%