FOG01577
EOG8ZKH5W

sce:FCY1

Genes: 34

SGD Description
Cytosine deaminase; zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)


AspGD Description
Cytosine deaminase


References

Erbs P, et al. (1997 Jan). Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans.

Ireton GC, et al. (2003 Aug). The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy.

Ko TP, et al. (2003 May 23). Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%