FOG01360
EOG8SQVCB

sce:MET5

Genes: 33

SGD Description
Sulfite reductase beta subunit; involved in amino acid biosynthesis, transcription repressed by methionine


PomBase Description
sulfite reductase Sir1


AspGD Description
Ortholog(s) have role in hydrogen sulfide biosynthetic process, sulfate assimilation, sulfur amino acid biosynthetic process and cytosol localization


References

YOSHIMOTO A, et al. (1961 Dec). A sulfite reductase from Aspergillus nidulans.

Kobayashi K, et al. (1982 Aug 10). Studies on yeast sulfite reductase. IV. Structure and steady-state kinetics.

Shevchenko A, et al. (1996 Dec 10). Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels.

Lussier M, et al. (1997 Oct). Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Brzywczy J, et al. (2011 Feb). Novel mutations reveal two important regions in Aspergillus nidulans transcriptional activator MetR.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%

FOG01361
EOG8SQVCB

sce:MET10

Genes: 32

SGD Description
Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide


PomBase Description
sulfite reductase NADPH flavoprotein subunit (predicted)


AspGD Description
Putative alpha subunit of assimilatory sulfite reductase


References

YOSHIMOTO A, et al. (1961 Dec). A sulfite reductase from Aspergillus nidulans.

Kobayashi K, et al. (1982 Aug 10). Studies on yeast sulfite reductase. IV. Structure and steady-state kinetics.

Hansen J, et al. (1994 Oct). Two divergent MET10 genes, one from Saccharomyces cerevisiae and one from Saccharomyces carlsbergensis, encode the alpha subunit of sulfite reductase and specify potential binding sites for FAD and NADPH.

Hosseini-Mazinani SM, et al. (1995). Cloning and sequencing of sulfite reductase alpha subunit gene from Saccharomyces cerevisiae.

Strunnikov AV, et al. (1995 Mar 1). SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family.

Kennedy PJ, et al. (2008 Nov). A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Shimizu M, et al. (2009 Jan). Proteomic analysis of Aspergillus nidulans cultured under hypoxic conditions.

Sato I, et al. (2009 Mar 20). The glutathione system of Aspergillus nidulans involves a fungus-specific glutathione S-transferase.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Bernal M, et al. (2014 Jun). Proteome-wide search for PP2A substrates in fission yeast.

Mathiassen SG, et al. (2015 Aug 21). A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG01362
EOG8SQVCB

sce:NCP1

Genes: 34

SGD Description
NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p


PomBase Description
NADPH-cytochrome p450 reductase


AspGD Description
Putative cytochrome P450 reductase; NADPH-ferrihemoprotein reductase; induced by benzoic acid; longer cprA-beta transcript carries a small uORF


References

Yabusaki Y, et al. (1988 Jun). Primary structure of Saccharomyces cerevisiae NADPH-cytochrome P450 reductase deduced from nucleotide sequence of its cloned gene.

Turi TG, et al. (1992 Jan 25). Multiple regulatory elements control expression of the gene encoding the Saccharomyces cerevisiae cytochrome P450, lanosterol 14 alpha-demethylase (ERG11).

Lesuisse E, et al. (1997 Nov 1). Cytochrome P-450 reductase is responsible for the ferrireductase activity associated with isolated plasma membranes of Saccharomyces cerevisiae.

Venkateswarlu K, et al. (1998 Feb 20). The N-terminal membrane domain of yeast NADPH-cytochrome P450 (CYP) oxidoreductase is not required for catalytic activity in sterol biosynthesis or in reconstitution of CYP activity.

Lamb DC, et al. (2001 Aug 10). Activities and kinetic mechanisms of native and soluble NADPH-cytochrome P450 reductase.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Hitchcock AL, et al. (2003 Oct 28). A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.

Keniry ME, et al. (2004 Mar). The identification of Pcl1-interacting proteins that genetically interact with Cla4 may indicate a link between G1 progression and mitotic exit.

Lamb DC, et al. (2006 Jan). A second FMN binding site in yeast NADPH-cytochrome P450 reductase suggests a mechanism of electron transfer by diflavin reductases.

Reinders J, et al. (2006 Jul). Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.

Zahedi RP, et al. (2006 Mar). Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins.

Aigrain L, et al. (2009 Jul). Structure of the open conformation of a functional chimeric NADPH cytochrome P450 reductase.

Ivanov AS, et al. (2010 Aug 20). FMN binding site of yeast NADPH-cytochrome P450 reductase exposed at the surface is highly specific.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 16 genes with posterior transmembrane prediction > 50%

FOG01363
EOG8SQVCB

sce:TAH18

Genes: 31

SGD Description
Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance; possible target for development of antifungal drugs


PomBase Description
NADPH-dependent diflavin oxidoreductase, involved in iron-sulfur cluster assembly Tah18 (predicted)


AspGD Description
Has domain(s) with predicted FMN binding, iron ion binding, oxidoreductase activity and role in oxidation-reduction process


References

Chanet R, et al. (2003 Aug). Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae.

Vernis L, et al. (2009). A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast.

Netz DJ, et al. (2010 Oct). Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis.

Soler N, et al. (2011 Oct). Interaction between the reductase Tah18 and highly conserved Fe-S containing Dre2 C-terminus is essential for yeast viability.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01364
EOG8SQVCB

sce:absent

Genes: 1

AspGD Description
NADPH-ferrihemoprotein reductase

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%