FOG01136
EOG8N02WC
PUT2
sce:PUT2

Genes: 35

Protein description
Delta-1-pyrroline-5-carboxylate dehydrogenase


SGD Description
Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant


PomBase Description
delta-1-pyrroline-5-carboxylate dehydrogenase (predicted)


AspGD Description
1-pyrroline-5-carboxylate dehydrogenase|1-pyrroline-5-carboxylate dehydrogenase|1-pyrroline-5-carboxylate dehydrogenase


References

Arst HN Jr, et al. (1978 Jul 6). Reduced expression of a distal gene of the prn gene cluster in deletion mutants of Aspergillus nidulans: genetic evidence for a dicistronic messenger in an eukaryote.

Jones SA, et al. (1981 Apr). Gene roles in the prn cluster of Aspergillus nidulans.

Krzywicki KA, et al. (1984 Dec). Primary structure of the nuclear PUT2 gene involved in the mitochondrial pathway for proline utilization in Saccharomyces cerevisiae.

Arst HN Jr, et al. (1984 Sep). Regulation of gene expression in Aspergillus nidulans.

Sharma KK, et al. (1985). The product of the regulatory gene of the proline catabolism gene cluster of Aspergillus nidulans is a positive-acting protein.

Durrens P, et al. (1986 Jun). Heterologous insertion of transforming DNA and generation of new deletions associated with transformation in Aspergillus nidulans.

Siddiqui AH, et al. (1988 Nov). A regulatory region responsible for proline-specific induction of the yeast PUT2 gene is adjacent to its TATA box.

Sophianopoulou V, et al. (1993 Jan). Operator derepressed mutations in the proline utilisation gene cluster of Aspergillus nidulans.

Scazzocchio C, et al. (1994). The proline utilisation pathway, history and beyond.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Cubero B, et al. (2000 Jan). Metabolite repression and inducer exclusion in the proline utilization gene cluster of Aspergillus nidulans.

Grandier-Vazeille X, et al. (2001 Aug 21). Yeast mitochondrial dehydrogenases are associated in a supramolecular complex.

Gómez D, et al. (2003 Oct). Multiple GATA sites: protein binding and physiological relevance for the regulation of the proline transporter gene of Aspergillus nidulans.

Salazar M, et al. (2009 Dec). Uncovering transcriptional regulation of glycerol metabolism in Aspergilli through genome-wide gene expression data analysis.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%