FOG00982
EOG8DFN4K
GDH3
sce:GDH1;GDH3

Genes: 33

Protein description
NADPH glutamate dehydrogenase, involved in glutamate anabolism


SGD Description
NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication|NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication


PomBase Description
NADP-specific glutamate dehydrogenase Gdh1 (predicted)


AspGD Description
NADP-dependent glutamate dehydrogenase; induced by growth on starch and lactate; expression repressed by tunicamycin and DTT


References

Pateman JA, et al. (1969 Dec). Regulation of synthesis of glutamate dehydrogenase and glutamine synthetase in micro-organisms.

Cohen BL, et al. (1973 Dec). Regulation of intracellular and extracellular neutral and alkaline proteases in Aspergillus nidulans.

Pateman JA, et al. (1973 Jun). Ammonium regulation in Aspergillus nidulans.

Arst HN Jr, et al. (1973 May 9). A mutant of Asperigillus nidulans lacking NADP-linked glutamate dehydrogenase.

Kinghorn JR, et al. (1973 Sep). NAD and NADP l-glutamate dehydrogenase activity and ammonium regulation in Aspergillus nidulans.

Hynes MJ, et al. (1974). Repression of enzymes of nitrogen catabolism by methylammonium and caesium chloride in strains of Aspergillus nidulans insensitive to ammonium repression.

Hynes MJ, et al. (1974 Dec). Effects of ammonium, L-glutamate, and L-glutamine on nitrogen catabolism in Aspergillus nidulans.

Hynes MJ, et al. (1974 Mar). The effects of carbon source on glutamate dehydrogenase activities in Aspergillus nidulans.

Johnson B, et al. (1974 Nov). The enzymes of ammonia assimilation in Schizosaccharomyces spp. and in Saccharomycodes ludwigii.

Arst HN Jr, et al. (1975). A mutant of Aspergillus nidulans defective in NAD-linked glutamate dehydrogenase.

Kinghorn JR, et al. (1975 Feb). The structural gene for NADP L-glutamate dehydrogenase in Aspergillus nidulans.

Bailey C, et al. (1975 Feb 21). Carbon catabolite repression in Aspergillos nidulans.

Kinghorn JR, et al. (1975 Sep 29). Studies of partially repressed mutants at the tamA and areA loci in Aspergillus nidulans.

Kinghorn JR, et al. (1976 Jan). Mutants of Aspergillus nidulans lacking nicotinamide adenine dinucleotide-specific glutamate dehydrogenase.

Garrett RH, et al. (1978). Nitrate assimilation in fungi.

Cove DJ, et al. (1979 Aug). Genetic studies of nitrate assimilation in Aspergillus nidulans.

Gill PP, et al. (1979 Jun). Effect of egg-white & avidin on the growth of Aspergillus nidulans & on its proteases & NADP-GDH.

Pateman JA, et al. (1982 Aug). Urea and thiourea transport in Aspergillus nidulans.

Osmani SA, et al. (1983 Jul 1). The sub-cellular localisation of pyruvate carboxylase and of some other enzymes in Aspergillus nidulans.

Nagasu T, et al. (1985). Nucleotide sequence of the GDH gene coding for the NADP-specific glutamate dehydrogenase of Saccharomyces cerevisiae.

Wiame JM, et al. (1985). Nitrogen catabolite repression in yeasts and filamentous fungi.

Moye WS, et al. (1985 Jul 15). Nucleotide sequence of yeast GDH1 encoding nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenase.

Gurr SJ, et al. (1986). Isolation and identification of the Aspergillus nidulans gdhA gene encoding NADP-linked glutamate dehydrogenase.

Stevens L, et al. (1989 Jan 15). Purification and characterisation of NAD-glutamate dehydrogenase from Aspergillus nidulans.

Hawkins AR, et al. (1989 Jul). Nucleotide sequence and regulation of expression of the Aspergillus nidulans gdhA gene encoding NADP dependent glutamate dehydrogenase.

Lloyd AT, et al. (1991 Nov). Codon usage in Aspergillus nidulans.

Kinghorn JR, et al. (1994). Inorganic nitrogen assimilation: molecular aspects.

Varga J, et al. (1994 Apr). Assignment of RFLP, RAPD and isoenzyme markers to Aspergillus nidulans chromosomes, using chromosome-substituted segregants of a hybrid of A. nidulans and A. quadrilineatus.

Perysinakis A, et al. (1995 Jun). Glutamine synthetase/glutamate synthase ammonium-assimilating pathway in Schizosaccharomyces pombe.

Norbeck J, et al. (1996 Mar 15). Protein expression during exponential growth in 0.7 M NaCl medium of Saccharomyces cerevisiae.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Cardoza RE, et al. (1998 Jul). Characterization and nitrogen-source regulation at the transcriptional level of the gdhA gene of Aspergillus awamori encoding an NADP-dependent glutamate dehydrogenase.

Macheda ML, et al. (1999 Jan). The Aspergillus nidulans gltA gene encoding glutamate synthase is required for ammonium assimilation in the absence of NADP-glutamate dehydrogenase.

Brakhage AA, et al. (1999 Jul-Aug). HAP-Like CCAAT-binding complexes in filamentous fungi: implications for biotechnology.

Santos M, et al. (2001 Dec). Characterization of the gdhA gene from the phytopathogen Botrytis cinerea.

Margelis S, et al. (2001 Oct). Role of glutamine synthetase in nitrogen metabolite repression in Aspergillus nidulans.

Morozov IY, et al. (2001 Oct). Characterization of nitrogen metabolite signalling in Aspergillus via the regulated degradation of areA mRNA.

Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.

Sims AH, et al. (2004 Feb). Use of expressed sequence tag analysis and cDNA microarrays of the filamentous fungus Aspergillus nidulans.

Polotnianka R, et al. (2004 Nov). TamA interacts with LeuB, the homologue of Saccharomyces cerevisiae Leu3p, to regulate gdhA expression in Aspergillus nidulans.

Davis MA, et al. (2005 Jul). Amino acid catabolism by an areA-regulated gene encoding an L-amino acid oxidase with broad substrate specificity in Aspergillus nidulans.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Shimizu M, et al. (2009 Jan). Proteomic analysis of Aspergillus nidulans cultured under hypoxic conditions.

Masuo S, et al. (2010 Dec). Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia.

Mercier A, et al. (2010 Jun). Iron-dependent remodeling of fungal metabolic pathways associated with ferrichrome biosynthesis.

Shimizu M, et al. (2010 Mar). Mechanism of de novo branched-chain amino acid synthesis as an alternative electron sink in hypoxic Aspergillus nidulans cells.

Schinko T, et al. (2010 Nov). Transcriptome analysis of nitrate assimilation in Aspergillus nidulans reveals connections to nitric oxide metabolism.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Etxebeste O, et al. (2012). GmcA is a putative glucose-methanol-choline oxidoreductase required for the induction of asexual development in Aspergillus nidulans.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Wartenberg D, et al. (2012 Jul 16). Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin.

Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Zhang L, et al. (2013). Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.

Downes DJ, et al. (2013 Dec). Regulation of the NADP-glutamate dehydrogenase gene gdhA in Aspergillus nidulans by the Zn(II)2Cys6 transcription factor LeuB.

Martins I, et al. (2013 Dec 6). Proteomic alterations induced by ionic liquids in Aspergillus nidulans and Neurospora crassa.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Downes DJ, et al. (2014 Jun). Dual DNA binding and coactivator functions of Aspergillus nidulans TamA, a Zn(II)2Cys6 transcription factor.

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%