FOG00898
EOG8JHB0V

sce:MGE1

Genes: 35

SGD Description
Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 (GRPEL1), which also responds to oxidative stress


PomBase Description
mitochondrial GrpE domain chaperone protein (predicted)


AspGD Description
Ortholog(s) have adenyl-nucleotide exchange factor activity, role in protein import into mitochondrial matrix, protein refolding and mitochondrial matrix, presequence translocase-associated import motor localization


References

Bolliger L, et al. (1994 Apr 15). A mitochondrial homolog of bacterial GrpE interacts with mitochondrial hsp70 and is essential for viability.

Ikeda E, et al. (1994 Feb 21). YGE1 is a yeast homologue of Escherichia coli grpE and is required for maintenance of mitochondrial functions.

Laloraya S, et al. (1994 Jul 5). A role for a eukaryotic GrpE-related protein, Mge1p, in protein translocation.

Westermann B, et al. (1995 Jul 17). The role of the GrpE homologue, Mge1p, in mediating protein import and protein folding in mitochondria.

Lutz T, et al. (2001 Mar 30). The mitochondrial proteins Ssq1 and Jac1 are required for the assembly of iron sulfur clusters in mitochondria.

van der Laan M, et al. (2005 Sep). Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lipp JJ, et al. (2015 Aug). SR protein kinases promote splicing of nonconsensus introns.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%