FOG00847
EOG83R24H

sce:SIM1;SUN4

Genes: 34

SGD Description
Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p); may participate in DNA replication; promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated; SIM1 has a paralog, SUN4, that arose from the whole genome duplication|Cell wall protein related to glucanases; possibly involved in cell wall septation; member of the SUN family; SUN4 has a paralog, SIM1, that arose from the whole genome duplication


PomBase Description
beta-glucosidase Psu2 (predicted)|cell wall protein Psu1, beta-glucosidase (predicted)


AspGD Description
Ortholog(s) have carbohydrate binding activity and role in (1->3)-beta-D-glucan catabolic process, hyphal growth


References

Dahmann C, et al. (1995 Nov 1). S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state.

Cappellaro C, et al. (1998 Oct). New potential cell wall glucanases of Saccharomyces cerevisiae and their involvement in mating.

Omi K, et al. (1999 Aug 27). Cloning and characterization of psu1(+), a new essential fission yeast gene involved in cell wall synthesis.

Mouassite M, et al. (2000 Jul). The 'SUN' family: yeast SUN4/SCW3 is involved in cell septation.

Velours G, et al. (2002 Feb 5). Dual cell wall/mitochondria localization of the 'SUN' family proteins.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Sohn K, et al. (2003 Jan). EFG1 is a major regulator of cell wall dynamics in Candida albicans as revealed by DNA microarrays.

Newport G, et al. (2003 Jan 17). Inactivation of Kex2p diminishes the virulence of Candida albicans.

De Groot PW, et al. (2003 Jul 15). Genome-wide identification of fungal GPI proteins.

Deutschbauer AM, et al. (2005 Dec). Quantitative trait loci mapped to single-nucleotide resolution in yeast.

Fedorova ND, et al. (2005 Dec 8). Comparative analysis of programmed cell death pathways in filamentous fungi.

Liu TT, et al. (2005 Jun). Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans.

Setiadi ER, et al. (2006 Aug 18). Transcriptional response of Candida albicans to hypoxia: linkage of oxygen sensing and Efg1p-regulatory networks.

de Groot PW, et al. (2007 Apr). Mass spectrometric identification of covalently bound cell wall proteins from the fission yeast Schizosaccharomyces pombe.

Firon A, et al. (2007 Dec). The SUN41 and SUN42 genes are essential for cell separation in Candida albicans.

Juneau K, et al. (2007 Jan 30). High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing.

Hiller E, et al. (2007 Nov). Candida albicans Sun41p, a putative glycosidase, is involved in morphogenesis, cell wall biogenesis, and biofilm formation.

Norice CT, et al. (2007 Nov). Requirement for Candida albicans Sun41 in biofilm formation and virulence.

Thomas DP, et al. (2009 Dec 1). A proteomic analysis of secretory proteins of a pre-vacuolar mutant of Candida albicans.

de Groot PW, et al. (2009 Mar). Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans.

Sahni N, et al. (2009 Oct). Genes selectively up-regulated by pheromone in white cells are involved in biofilm formation in Candida albicans.

Paul SK, et al. (2009 Sep). A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.

Cho SJ, et al. (2010 Jun). Possible Roles of LAMMER Kinase Lkh1 in Fission Yeast by Comparative Proteome Analysis.

Sorgo AG, et al. (2011 Aug). Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Kwon EJ, et al. (2012). Deciphering the transcriptional-regulatory network of flocculation in Schizosaccharomyces pombe.

Kuznetsov E, et al. (2013). SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level.

Gastebois A, et al. (2013 May 10). SUN proteins belong to a novel family of β-(1,3)-glucan-modifying enzymes involved in fungal morphogenesis.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00848
EOG83R24H

sce:NCA3;UTH1

Genes: 23

SGD Description
Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication|Mitochondrial inner membrane protein; role in mitophagy is disputed; implicated in cell wall biogenesis, the oxidative stress response, life span during starvation, and cell death; SUN family member; UTH1 has a paralog, NCA3, that arose from the whole genome duplication


References

Pélissier P, et al. (1995 Apr). NCA3, a nuclear gene involved in the mitochondrial expression of subunits 6 and 8 of the Fo-F1 ATP synthase of S. cerevisiae.

Kennedy BK, et al. (1995 Feb 10). Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae.

Bandara PD, et al. (1998 Oct). Involvement of the Saccharomyces cerevisiae UTH1 gene in the oxidative-stress response.

Mouassite M, et al. (2000 Jan 1). The SUN family of Saccharomyces cerevisiae: the double knock-out of UTH1 and SIM1 promotes defects in nucleus migration and increased drug sensitivity.

Mouassite M, et al. (2000 Jul). The 'SUN' family: yeast SUN4/SCW3 is involved in cell septation.

Camougrand NM, et al. (2000 Mar 1). The "SUN" family: UTH1, an ageing gene, is also involved in the regulation of mitochondria biogenesis in Saccharomyces cerevisiae.

Velours G, et al. (2002 Feb 5). Dual cell wall/mitochondria localization of the 'SUN' family proteins.

Camougrand N, et al. (2003 Jan). The product of the UTH1 gene, required for Bax-induced cell death in yeast, is involved in the response to rapamycin.

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Lotz H, et al. (2004 Jun). RBR1, a novel pH-regulated cell wall gene of Candida albicans, is repressed by RIM101 and activated by NRG1.

Kissová I, et al. (2004 Sep 10). Uth1p is involved in the autophagic degradation of mitochondria.

Zhang Z, et al. (2005). Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE.

Firon A, et al. (2007 Dec). The SUN41 and SUN42 genes are essential for cell separation in Candida albicans.

Kissová I, et al. (2007 Jul-Aug). Selective and non-selective autophagic degradation of mitochondria in yeast.

Fernández-Arenas E, et al. (2007 Mar). Integrated proteomics and genomics strategies bring new insight into Candida albicans response upon macrophage interaction.

Hiller E, et al. (2007 Nov). Candida albicans Sun41p, a putative glycosidase, is involved in morphogenesis, cell wall biogenesis, and biofilm formation.

Sosinska GJ, et al. (2008 Feb). Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions.

Sorgo AG, et al. (2011 Aug). Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Nobile CJ, et al. (2012 Jan 20). A recently evolved transcriptional network controls biofilm development in Candida albicans.

Kuznetsov E, et al. (2013). SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%