FOG00837
EOG8P8D18
NDI0
sce:absent

Genes: 6

Protein description
Internal NADH dehydrogenase, orthologous to NDH2 in E. coli


Features
NADH


AspGD Description
Ortholog(s) have NADPH dehydrogenase activity, role in spore germination and mitochondrial inner membrane localization


References

Dinamarco TM, et al. (2010 Dec). The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance.

Dinamarco TM, et al. (2011 Oct). Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG00838
EOG8P8D18
NDE0
sce:absent

Genes: 22

Protein description
External NADH and NADPH dehydrogenase


Features
NADH;NADPH


Parent
paralog:FOG00837


AspGD Description
NADH-ubiquinone oxidoreductase; respiratory-chain NADH dehydrogenase

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 21 genes with posterior transmembrane prediction > 50%

FOG00839
EOG8P8D18
NDE1
sce:absent

Genes: 33

Protein description
External NADH and NADPH dehydrogenase, spo ortholog may have translate sites than enable internal NADH dehydrogenase


Features
NADH;NADPH


Parent
paralog:FOG00838


PomBase Description
mitochondrial NADH dehydrogenase (ubiquinone) Nde2 (predicted)


AspGD Description
NADH-ubiquinone oxidoreductase; respiratory-chain NADH dehydrogenase


References

Kerscher SJ, et al. (1999 Jul). A single external enzyme confers alternative NADH:ubiquinone oxidoreductase activity in Yarrowia lipolytica.

Todd BL, et al. (2006 Apr). Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Dinamarco TM, et al. (2010 Dec). The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance.

Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Dinamarco TM, et al. (2011 Oct). Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans.

Lando D, et al. (2012). The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Guo L, et al. (2016 Oct 13). Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 31 genes with posterior transmembrane prediction > 50%

FOG00840
EOG8P8D18
NDE1.2
sce:absent

Genes: 1

Protein description
External NADH and NADPH dehydrogenase, spo ortholog may have translate sites than enable internal NADH dehydrogenase


Parent
paralog:FOG00839


PomBase Description
mitochondrial NADH dehydrogenase (ubiquinone) Nde1 (predicted)

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00841
EOG8P8D18
NDE1
sce:NDE1

Genes: 2

Protein description
External NADH dehydrogenase, loss of NADPH activity


Parent
ortholog:FOG00839


SGD Description
Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog, NDE2, that arose from the whole genome duplication


References

Small WC, et al. (1998 Aug). Identification of a cytosolically directed NADH dehydrogenase in mitochondria of Saccharomyces cerevisiae.

Luttik MA, et al. (1998 Sep 18). The Saccharomyces cerevisiae NDE1 and NDE2 genes encode separate mitochondrial NADH dehydrogenases catalyzing the oxidation of cytosolic NADH.

Kerscher SJ, et al. (2000 Aug 15). Diversity and origin of alternative NADH:ubiquinone oxidoreductases.

Overkamp KM, et al. (2000 May). In vivo analysis of the mechanisms for oxidation of cytosolic NADH by Saccharomyces cerevisiae mitochondria.

Joseph-Horne T, et al. (2001 Apr 2). Fungal respiration: a fusion of standard and alternative components.

Grandier-Vazeille X, et al. (2001 Aug 21). Yeast mitochondrial dehydrogenases are associated in a supramolecular complex.

Davidson JF, et al. (2001 Dec). Mitochondrial respiratory electron carriers are involved in oxidative stress during heat stress in Saccharomyces cerevisiae.

Bakker BM, et al. (2001 Jan). Stoichiometry and compartmentation of NADH metabolism in Saccharomyces cerevisiae.

Påhlman IL, et al. (2002 Aug 2). Kinetic regulation of the mitochondrial glycerol-3-phosphate dehydrogenase by the external NADH dehydrogenase in Saccharomyces cerevisiae.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG00842

NDI2
sce:absent

Genes: 1

Features
NADH


Parent
paralog:FOG00839

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00843

NDE1.3
sce:absent

Genes: 2

Protein description
External NADH and NADPH dehydrogenase


Parent
paralog:FOG00841

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG00844

NDE1.4
sce:absent

Genes: 1

Protein description
External NADH and NADPH dehydrogenase


Parent
paralog:FOG00843

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00845
EOG8P8D18
NDE2
sce:NDE2

Genes: 1

Protein description
External NADH dehydrogenase


Features
NADH


Parent
ohnolog:FOG00841


SGD Description
Mitochondrial external NADH dehydrogenase; catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain; NDE2 has a paralog, NDE1, that arose from the whole genome duplication


References

Zhu QS, et al. (1988 Jan 5). Direct interaction between yeast NADH-ubiquinone oxidoreductase, succinate-ubiquinone oxidoreductase, and ubiquinol-cytochrome c oxidoreductase in the reduction of exogenous quinones.

Shankar CS, et al. (1996 Sep). Mitochondrial NADH dehydrogenase activity and ability to tolerate acetaldehyde determine faster ethanol production in Saccharomyces cerevisiae.

Luttik MA, et al. (1998 Sep 18). The Saccharomyces cerevisiae NDE1 and NDE2 genes encode separate mitochondrial NADH dehydrogenases catalyzing the oxidation of cytosolic NADH.

Kerscher SJ, et al. (2000 Aug 15). Diversity and origin of alternative NADH:ubiquinone oxidoreductases.

Overkamp KM, et al. (2000 May). In vivo analysis of the mechanisms for oxidation of cytosolic NADH by Saccharomyces cerevisiae mitochondria.

Grandier-Vazeille X, et al. (2001 Aug 21). Yeast mitochondrial dehydrogenases are associated in a supramolecular complex.

Davidson JF, et al. (2001 Dec). Mitochondrial respiratory electron carriers are involved in oxidative stress during heat stress in Saccharomyces cerevisiae.

Bakker BM, et al. (2001 Jan). Stoichiometry and compartmentation of NADH metabolism in Saccharomyces cerevisiae.

Påhlman IL, et al. (2002 Aug 2). Kinetic regulation of the mitochondrial glycerol-3-phosphate dehydrogenase by the external NADH dehydrogenase in Saccharomyces cerevisiae.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00846
EOG8P8D18
NDI1
sce:NDI1

Genes: 9

Protein description
Internal NADH dehydrogenase


Features
NADH


Parent
paralog:FOG00839


SGD Description
NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID


References

De Vries S, et al. (1992 Feb 1). Primary structure and import pathway of the rotenone-insensitive NADH-ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae.

Small WC, et al. (1998 Aug). Identification of a cytosolically directed NADH dehydrogenase in mitochondria of Saccharomyces cerevisiae.

Luttik MA, et al. (1998 Sep 18). The Saccharomyces cerevisiae NDE1 and NDE2 genes encode separate mitochondrial NADH dehydrogenases catalyzing the oxidation of cytosolic NADH.

Grandier-Vazeille X, et al. (2001 Aug 21). Yeast mitochondrial dehydrogenases are associated in a supramolecular complex.

Reinders J, et al. (2007 Nov). Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.

Renvoisé M, et al. (2014 Jun 25). Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 9 genes with posterior transmembrane prediction > 50%